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One-Year Efficacy of Guselkumab Versus Advanced Therapies for the Treatment of Moderately to Severely Active Crohn's Disease: A Network Meta-Analysis
Publication Year: 2025 Source: Adv Ther PMID: 40327280
INTRODUCTION: This study used network meta-analysis (NMA) to evaluate the comparative efficacy of available advanced therapies for moderately to severely active Crohn's disease (CD) versus the IL-23 inhibitor guselkumab. METHODS: A systematic literature review was conducted to identify randomized controlled trials (RCTs) of advanced therapies in moderately to severely active …
The real-world effectiveness of ustekinumab in patients with ulcerative colitis in the United States
Publication Year: 2025 Source: Curr Med Res Opin PMID: 40327500 DOI: 10.1080/03007995.2025.2494642
BACKGROUND: Ustekinumab was approved for use in the treatment of moderate/severe ulcerative colitis (UC) in 2019. Though it has proven effective in clinical trials, evidence of its effectiveness in clinical practice is limited to the published reports of use in clinical practice. This study assessed ustekinumab effectiveness in patients with …
De novo DUOX2 expression in neutrophil subsets shapes the pathogenesis of intestinal disease
Publication Year: 2025 Source: Proc Natl Acad Sci U S A PMID: 40327691 DOI: 10.1073/pnas.2421747122
Infiltrating neutrophils are key effector cells in inflammatory bowel disease (IBD) while providing antimicrobial defense and tissue restitution in the intestine. The complexity of neutrophil functions in local environments underscores our limited understanding of how their adaptation in tissues influences disease progression. Here, we demonstrate that neutrophils recruited in murine …
Multifaceted Endoscopic Approach (Stricturotomy, Balloon Dilation, Fistulotomy, and Seton Placement) Guided by Intestinal Ultrasound to Avert Surgery in Complicated Crohn's Disease During Lactation
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40327777
No Abstract
Epidemiological characteristics of infectious bursal disease virus (IBDV) in China from 2023 to 2024: Mutated very virulent IBDV (mvvIBDV) is associated with atypical IBD
Publication Year: 2025 Source: Poult Sci PMID: 40328040 DOI: 10.1016/j.psj.2025.105195
Infectious bursal disease (IBD), caused by the infectious bursal disease virus (IBDV), threatens the global poultry industry with acute immunosuppression. The non-lethal novel variant IBDV (nVarIBDV) has been identified as the primary cause of a new outbreak of atypical IBD in China. However, since 2023, several poultry farms in China …
RNF186 gene variant and zonulin levels in inflammatory bowel disease: A pilot study
Publication Year: 2025 Source: Arab J Gastroenterol PMID: 40328563 DOI: 10.1016/j.ajg.2025.02.005
BACKGROUND AND STUDY AIM: Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract characterized by inflammation and ulceration of the intestinal mucosa, represented by Crohn's disease (CD) and ulcerative colitis (UC). The aim of this study is to investigate the relationship between the Ring Finger Protein …
Secondary Cancer after Androgen Deprivation Therapy in Prostate Cancer: A Nationwide Study
Publication Year: 2025 Source: World J Mens Health PMID: 38606859 DOI: 10.5534/wjmh.230237
PURPOSE: Androgen signaling is associated with various secondary cancer, which could be promising for potential treatment using androgen deprivation therapy (ADT). This study investigated whether ADT use was associated with secondary cancers other than prostate cancer in a nationwide population-based cohort. MATERIALS AND METHODS: A total, 278,434 men with newly …
In Patients With Inflammatory Bowel Disease, Racial Disparities Exist in Burden of Vaccine-preventable Disease Hospitalizations and Outcomes
Publication Year: 2025 Source: J Clin Gastroenterol PMID: 38619208 DOI: 10.1097/MCG.0000000000002005
OBJECTIVE: Patients with inflammatory bowel disease (IBD) are at increased risk of vaccine-preventable diseases (VPDs). Despite the increasing prevalence of IBD in non-white populations, little is known regarding racial disparities in VPD burden. METHODS: Retrospectively analyzing the 2016 to 2020 National Inpatient Sample, we identified adults with IBD hospitalized for …
The incidence of Clostridium difficile infection in children with and without inflammatory bowel diseases: A single-center study in Taiwan from 2006 to 2019
Publication Year: 2025 Source: J Formos Med Assoc PMID: 38631957 DOI: 10.1016/j.jfma.2024.04.006
BACKGROUND: The incidence of Clostridium difficile infection (CDI) is increasing around the world, and patients with inflammatory bowel disease (IBD) have a higher risk of obtaining CDI. The data on the incidence rate of CDI in the Asian pediatric IBD population was lacking. METHODS: We retrospectively collected data from a …
Active microscopic colitis precipitated by fluoxetine
Publication Year: 2025 Source: Rev Esp Enferm Dig PMID: 38634864
Microscopic colitis is a form of chronic and recurrent inflammatory bowel disease characterized by non-bloody, watery diarrhea, macroscopically normal colonic mucosa, and characteristic histopathological findings. Some drugs have been described as triggers of colonic inflammation in predisposed individuals, while others may exacerbate microscopic colitis that evolves on its own. We …
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