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Foreign body-induced Colovesical fistula: A case report
Publication Year: 2025 Source: Int J Surg Case Rep PMID: 40652869
BACKGROUND: Colovesical fistula (CVF) is a rare condition characterized by an abnormal connection between the colon and the urinary bladder. While diverticular disease is the most common cause, this report describes a unique case of CVF resulting from an ingested foreign body. CASE PRESENTATION: A 78-year-old woman with a history …
EVOLVE-IBERIA: Real-world evidence on vedolizumab and anti-tumor necrosis factor-α as first- or second-line biologic treatment among patients with ulcerative colitis
Publication Year: 2025 Source: Gastroenterol Hepatol PMID: 40653009
OBJECTIVE: Real-world evidence (RWE) on vedolizumab (VDZ), an anti-lymphocyte trafficking treatment that selectively targets the alpha4beta7/MAdCAM-1 interaction on the gut, is mostly limited to patients who are repeatedly refractory to anti-tumor necrosis factor-alpha (anti-TNF-alpha), and other treatments. The EVOLVE-IBERIA study assessed VDZ or anti-TNF-alpha as first- or second-line biologic treatment, …
Combining epidemiology, network toxicology and in vivo experimental validation to uncover takeout-mediated DEHP/MEHP toxicity in inflammatory bowel disease
Publication Year: 2025 Source: Free Radic Biol Med PMID: 40653097
BACKGROUND AND AIMS: Mono (2-ethylhexyl) phthalate (MEHP), the active metabolite of di-(2-ethylhexyl) phthalate (DEHP), is a widely used plasticizer in food packaging materials. While DEHP/MEHP has been linked to various health risks, the underlying mechanisms between DEHP/MEHP exposure and inflammatory bowel disease (IBD) remain poorly understood. This study aims to …
Immunogenicity and efficacy of subcutaneous infliximab monotherapy versus combination therapy in IBD
Publication Year: 2025 Source: Clin Gastroenterol Hepatol PMID: 40653287
No Abstract
Platycodon grandiflorus polysaccharides combined with hesperidin exerted the synergistic effect of relieving ulcerative colitis in mice by modulating PI3K/AKT and JAK2/STAT3 signaling pathways
Publication Year: 2025 Source: Chin J Nat Med PMID: 40653325
Ulcerative colitis (UC) is a chronic inflammatory disorder with a complex etiology, characterized by intestinal inflammation and barrier dysfunction. Platycodon grandiflorus polysaccharides (PGP), the primary component of Platycodon grandiflorus, and hesperidin (Hesp), a prominent active component in Citrus aurantium L. (CAL), have both demonstrated anti-inflammatory properties. This study aims to …
Effect of microbial dysbiosis on autoimmune associated inflammation
Publication Year: 2025 Source: Int Rev Cell Mol Biol PMID: 40653352
Trillions of microorganisms inhabit the human body, playing crucial roles in the development of the immune system, maintaining balance within the gut's immune system, and overall well-being. When these microbial communities experience imbalance, known as dysbiosis, it can lead to localized inflammatory conditions such as colitis and inflammatory bowel diseases, …
Circulating Inflammatory Proteins Mediate the Causal Effect of Gut Microbiota on Inflammatory Bowel Disease: Bayesian and Mediated Mendelian Randomization
Publication Year: 2025 Source: FASEB Bioadv PMID: 40654330
Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), presents a global public health challenge. Although the relationships between gut microbiota, inflammatory proteins, and IBD are recognized, their causal associations and mediating roles remain unclear. Large-scale genome-wide association study data on 473 gut microbiota, 91 circulating inflammatory …
Anti-Inflammatory Activity and Mechanism of Stearic Acid Extract From Purslane
Publication Year: 2025 Source: Food Sci Nutr PMID: 40654533
Purslane, as a traditional edible and medicinal herb, has been proven to have good anti-inflammatory activity. In this study, it was clarified that stearic acid was the main anti-inflammatory substance in purslane and could decrease the secretion of inflammatory cytokines, tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-10 (IL-10) in …
Gut microbiota dysbiosis in inflammatory bowel disease: interaction with intestinal barriers and microbiota-targeted treatment options
Publication Year: 2025 Source: Front Cell Infect Microbiol PMID: 40654576
Recent studies have deepened our understanding on gut microbiota alterations and the interaction with intestinal barrier impairments, which play a crucial role in the etiology and pathophysiology of Inflammatory bowel disease (IBD). The intestinal microbiota dysbiosis in IBD including the altered microbiota composition, decreased beneficial species and increased harmful species. …
Miniature bioreactor arrays for modeling functional and structural dysbiosis in inflammatory bowel disease
Publication Year: 2025 Source: bioRxiv PMID: 40654794
Alterations in the gut microbiota, known as gut dysbiosis, are associated with inflammatory bowel disease (IBD). There is a need for model systems that can recapitulate the IBD gut microbiome to better understand the mechanistic impact of differences in microbiota composition and its functional consequences in a controlled laboratory setting. …
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