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Optimising Sampling Design for Landscape Genomics

Publication Year: 2025 Source: Mol Ecol Resour PMID: 39690494 DOI: 10.1111/1755-0998.14052

Landscape genomic approaches for detecting genotype-environment associations (GEA), isolation by distance (IBD) and isolation by environment (IBE) have seen a dramatic increase in use, but there have been few thorough analyses of the influence of sampling strategy on their performance under realistic genomic and environmental conditions. We simulated 24,000 datasets …

Intestinal histopathology in pediatric PSC-IBD: Characterization of phenotype and assessment of the Nancy Index

Publication Year: 2025 Source: J Pediatr Gastroenterol Nutr PMID: 39690834 DOI: 10.1002/jpn3.12434

OBJECTIVES: We aimed to characterize the histologic gut phenotype of pediatric primary sclerosing cholangitis (PSC)-associated inflammatory bowel disease (IBD) against non-PSC colitis, and to assess Nancy Index (NI) performance in pediatric PSC-IBD. METHODS: Single-center retrospective cohort study including children diagnosed with PSC-IBD or non-PSC colitis (ulcerative colitis [UC] or IBD-unclassified) …

Wolfberry Honey and Its Extract Alleviate Dextran Sodium Sulfate-Induced Ulcerative Colitis by Improving Intestinal Barrier Function and Reducing Oxidative Stress and Inflammation

Publication Year: 2025 Source: Mol Nutr Food Res PMID: 39690893 DOI: 10.1002/mnfr.202400726

Inflammatory bowel disease (IBD) is a chronic condition characterized by gut inflammation causing persistent diarrhea and abdominal pain. Despite the nutritional benefits of wolfberry honey (from Lycium barbarum L.), its potential to alleviate IBD remains underexplored. This study evaluated the protective effects of wolfberry honey and its extract (wolfberry honey …

Development and Validation of a Multimodal Machine Learning Model for Diagnosing and Assessing Risk of Crohn's Disease in Patients With Perianal Fistula

Publication Year: 2025 Source: Aliment Pharmacol Ther PMID: 39692571

No Abstract

Oral manifestations of Crohn disease managed with ustekinumab: A case report

Publication Year: 2025 Source: J Am Dent Assoc PMID: 39692644

No Abstract

Challenging Conventional Care: Ethical Considerations of De-intensification of Therapy in IBD

Publication Year: 2025 Source: Gastroenterology PMID: 39692680 DOI: 10.1053/j.gastro.2024.09.031

No Abstract

Discordance between MR enterography and endoscopic detection of Crohn's disease ileal strictures: evidence to inform recommendations

Publication Year: 2025 Source: Abdom Radiol (NY) PMID: 39692760

No Abstract

The Urgency Numeric Rating Scale: Psychometric Evaluation in Adults with Crohn's Disease

Publication Year: 2025 Source: Adv Ther PMID: 39692838

No Abstract

Mirikizumab pharmacokinetics and exposure-response in pediatric patients with moderate-to-severe ulcerative colitis

Publication Year: 2025 Source: CPT Pharmacometrics Syst Pharmacol PMID: 39693227

No Abstract

Disruption of Epithelial Barrier Integrity via Altered GILZ/c-Rel/RACK1 Signaling in Inflammatory Bowel Disease

Publication Year: 2025 Source: J Crohns Colitis PMID: 39693354 DOI: 10.1093/ecco-jcc/jjae191

BACKGROUND AND AIMS: Given the role of Receptor for Activated C Kinase 1 (RACK1) in both immune cell activation and in the maintenance of the intestinal epithelial barrier integrity, we investigated whether it was involved in inflammatory bowel disease (IBD). METHODS: RACK1 expression was analyzed in intestinal mucosal samples of …

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