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Human artificial chromosome carrying R-spondin1 and IL-22 expression cassettes in rejuvenated MSCs enhances therapeutic efficacy in ulcerative colitis model mice
Publication Year: 2025 Source: Biomed Pharmacother PMID: 39693903
No Abstract
A Randomized Phase II Study of Efmarodocokin Alfa, an interleukin-22 Agonist, Versus Vedolizumab in Patients With Ulcerative Colitis
Publication Year: 2025 Source: Clin Gastroenterol Hepatol PMID: 39694207
No Abstract
Crohn's Disease with Granulomatous Interstitial Nephritis as an Extraintestinal Complication from the Time of the Diagnosis
Publication Year: 2025 Source: Intern Med PMID: 39694489
No Abstract
Community pharmacist-led point-of-care colorectal cancer screening program: Early detection of colorectal cancer in high-risk patients
Publication Year: 2025 Source: Res Social Adm Pharm PMID: 39694778 DOI: 10.1016/j.sapharm.2024.12.006
BACKGROUND: The prevalence of colorectal cancer (CRC) is on the rise among the younger population, with an anticipated increase in new cases for individuals aged 20-49 years by 2030. The accessibility of community pharmacists and their strong community connections present unique opportunities to enhance patient engagement in a population-based CRC …
Concise Commentary: Out for Blood-Persisting Racial Disparities of Postoperative Complications in Minority Patients with IBD
Publication Year: 2025 Source: Dig Dis Sci PMID: 39694993 DOI: 10.1007/s10620-024-08779-x
No Abstract
Paroxetine alleviates ulcerative colitis in mice via restoring intestinal microbiota homeostasis and metabolism
Publication Year: 2025 Source: Basic Clin Pharmacol Toxicol PMID: 39696778
Ulcerative colitis (UC) is an inflammatory bowel disease and psychological factors may be one of its pathogeneses. Selective serotonin reuptake inhibitor drug such as paroxetine with an effective anti-depression ability may be a new option for UC treatment. To evaluate the therapeutic effect of paroxetine on the exacerbation of UC …
Evolution of Eligibility Criteria in Inflammatory Bowel Disease Clinical Trials: A Clinical Trial Databank Analysis
Publication Year: 2025 Source: United European Gastroenterol J PMID: 39698868 DOI: 10.1002/ueg2.12731
BACKGROUND: Eligibility criteria in clinical trials have been criticised for being overly restrictive without clinical justification. OBJECTIVE: We aimed to investigate the types, evolution, and current status of eligibility criteria in clinical trials for inflammatory bowel diseases (IBD). METHODS: We performed a clinical trial databank search on clinicaltrials.gov, and included …
Phillyrin ameliorates DSS-induced colitis in mice via modulating the gut microbiota and inhibiting the NF-κB/MLCK pathway
Publication Year: 2025 Source: Microbiol Spectr PMID: 39699220
No Abstract
Identification of antigen-presenting cell-T cell interactions driving immune responses to food
Publication Year: 2025 Source: Science PMID: 39700315
The intestinal immune system must concomitantly tolerate food and commensals and protect against pathogens. Antigen-presenting cells (APCs) orchestrate these immune responses by presenting luminal antigens to CD4(+) T cells and inducing their differentiation into regulatory (peripheral regulatory T cell) or inflammatory [T helper (Th) cell] subsets. We used a proximity …
Clinical Outcomes After First-Line Anti- Tumor-Necrosis-Factor Treatment of Patients With Inflammatory Bowel Disease-A Prospective Multicenter Cohort Study
Publication Year: 2025 Source: J Crohns Colitis PMID: 39700468 DOI: 10.1093/ecco-jcc/jjae192
BACKGROUND AND AIMS: Existing findings on outcomes of anti-tumor-necrosis-factor (TNF) therapy in patients with inflammatory bowel diseases (IBD) are largely based on retrospective studies. We aimed to investigate real-world outcomes of anti-TNF therapy and predictors thereof in a prospective IBD cohort. METHODS: In a Danish multicenter cohort of adult bio-naive …
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