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Eleven Grand Challenges for Inflammatory Bowel Disease Genetics and Genomics
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 39700476 DOI: 10.1093/ibd/izae269
The past 2 decades have witnessed extraordinary advances in our understanding of the genetic factors influencing inflammatory bowel disease (IBD), providing a foundation for the approaching era of genomic medicine. On behalf of the NIDDK IBD Genetics Consortium, we herein survey 11 grand challenges for the field as it embarks …
Association between nutrient intake and inflammatory bowel disease risk: Insights from NHANES data and dose-response analysis
Publication Year: 2025 Source: Nutrition PMID: 39700661 DOI: 10.1016/j.nut.2024.112632
BACKGROUND: The role of dietary and nutritional factors in inflammatory bowel disease (IBD) remains poorly understood, necessitating further investigation. This study aims to explore the association between nutrient intake and the risk of IBD. METHODS: This cross-sectional study utilized data from the 2009-2010 NHANES cycle, focusing on individuals with complete …
Intestinal E. coli-produced yersiniabactin promotes profibrotic macrophages in Crohn's disease
Publication Year: 2025 Source: Cell Host Microbe PMID: 39701098 DOI: 10.1016/j.chom.2024.11.012
Inflammatory bowel disease (IBD)-associated fibrosis causes significant morbidity. Mechanisms are poorly understood but implicate the microbiota, especially adherent-invasive Escherichia coli (AIEC). We previously demonstrated that AIEC producing the metallophore yersiniabactin (Ybt) promotes intestinal fibrosis in an IBD mouse model. Since macrophages interpret microbial signals and influence inflammation/tissue remodeling, we hypothesized …
Deriving Human Intestinal Organoids with Functional Tissue-Resident Macrophages All From Pluripotent Stem Cells
Publication Year: 2025 Source: Cell Mol Gastroenterol Hepatol PMID: 39701210
No Abstract
Flavonifractor plautii bacteremia following bacterial translocation from the gut: A case report and literature review
Publication Year: 2025 Source: J Infect Chemother PMID: 39701278
No Abstract
Meta analysis of the influencing factors of sarcopenia in patients with Crohn's disease
Publication Year: 2025 Source: Am J Med Sci PMID: 39701417
No Abstract
Persistence of advanced therapies in patients with inflammatory bowel disease: retrospective cohort study using a large healthcare claims database in Japan
Publication Year: 2025 Source: Intest Res PMID: 39701922 DOI: 10.5217/ir.2024.00118
BACKGROUND/AIMS: There are few studies that comprehensively report real-world persistence for first-line advanced therapies used to treat inflammatory bowel disease. We aimed to describe persistence of first-line advanced therapies among incident biologic or Janus kinase inhibitor users with inflammatory bowel disease. METHODS: Retrospective cohort study using the Japan Medical Data …
Synergistic Benefits of Dietary Strategies in the Management of IBD
Publication Year: 2025 Source: Curr Gastroenterol Rep PMID: 39702516 DOI: 10.1007/s11894-024-00949-1
PURPOSE OF REVIEW: Inflammatory bowel disease (IBD) patients commonly inquire about the role of diet in the onset and management of their disease process. This review sought to assess the impact of the inflammatory bowel diseases on the nutritional state of patients and evaluate the evidence supporting nutritional interventions as …
Emerging role of small RNAs in inflammatory bowel disease and associated colorectal cancer (Review)
Publication Year: 2025 Source: Int J Mol Med PMID: 39704210 DOI: 10.3892/ijmm.2024.5474
Inflammatory bowel diseases (IBDs), which encompasses Crohn's disease and ulcerative colitis, is a chronic inflammatory condition associated with an increased risk of colorectal cancer (CRC). Small RNAs have been linked to various illnesses, including IBD and CRC. These small RNAs also serve as potential biomarkers for these diseases, offering a …
Prevalence and sequelae of asymptomatic Clostridioides difficile colonization in children with inflammatory bowel disease
Publication Year: 2025 Source: J Pediatr Gastroenterol Nutr PMID: 39704253 DOI: 10.1002/jpn3.12439
Colonization by Clostridioides difficile is common in children with inflammatory bowel disease (IBD) and complicates both the management of IBD and the diagnosis of C. difficile infection (CDI). There is a paucity of data on rates, risk factors, and outcomes associated with asymptomatic C. difficile colonization in children with IBD. …
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