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Predicting resistance to biological therapy using human leukocyte antigen genes in patients with inflammatory bowel disease
Publication Year: 2025 Source: Therap Adv Gastroenterol PMID: 40655132
BACKGROUND: The efficacy of anti-tumor necrosis factor (TNF) therapy in inflammatory bowel disease (IBD) is often compromised by the development of antidrug antibodies. In this setting, the human leukocyte antigen (HLA)-DQA1*05 allele has been significantly associated with the formation of antidrug antibodies to anti-TNF agents, loss of response, and treatment …
Youth feedback through emotional mapping in the Transition to Adulthood through Coaching and Empowerment study
Publication Year: 2025 Source: Health Care Transit PMID: 40655467
BACKGROUND: Youth with inflammatory bowel disease (IBD) and juvenile idiopathic arthritis (JIA) face challenges transitioning to adult care due to physiological and psychosocial impacts of their disease. Current transition care models vary, and few have been comprehensively evaluated. Previously, we conducted a feasibility randomized-controlled trial (TRACE - Transition to Adulthood …
The Potential Role and Effective Components of Sanyeqing as the Potential Therapeutic Candidates for IBD and CRC
Publication Year: 2025 Source: Onco Targets Ther PMID: 40655939
Inflammatory bowel disease (IBD) is a family of chronic inflammatory diseases such as Crohn's disease (CD) and ulcerative colitis (UC). Among the serious malignancies that can arise from IBD, colorectal cancer is particularly prevalent. Individuals suffering from both IBD and CRC often endure similar symptoms, which include diarrhea, rectal bleeding, …
Protective effect of Henna (Lawsonia inermis L.) fixed oil (a Persian medicine preparation) on acetic acid-induced ulcerative colitis in rats
Publication Year: 2025 Source: Avicenna J Phytomed PMID: 40656621
OBJECTIVE: Ulcerative colitis is a chronic recurrent inflammatory bowel disease of unknown etiology. The anti-inflammatory, immunomodulatory, and antioxidant characteristics of Henna ( Lawsonia inermis) fixed oil (HFO) imply that it may be advantageous for the treatment of colitis. MATERIALS AND METHODS: In this research, the effect of HFO in a …
Impact of COVID-19 on Venous Thromboembolism in Inflammatory Bowel Disease Hospitalizations: A Propensity-Matched Analysis
Publication Year: 2025 Source: JGH Open PMID: 40657470
BACKGROUND AND AIM: Patients diagnosed with Inflammatory bowel disease (IBD) face a notably higher risk of venous thromboembolism (VTE), leading to significant health challenges. Similarly, coronavirus disease 2019 (COVID-19) is associated with an increased susceptibility to thrombosis. We aimed to assess the impact of COVID-19 on the risk of developing …
Nutrition in inflammatory bowel disease: new trends
Publication Year: 2025 Source: Curr Opin Clin Nutr Metab Care PMID: 40657733
PURPOSE OF REVIEW: This review examines the latest evidence and highlights the importance of personalized dietary therapies to augment conventional medical treatments in the treatment of inflammatory bowel disease. RECENT FINDINGS: Diversity in the maternal diet may reduce the risk of development of ulcerative colitis in utero, while a diverse …
The sick gut with diarrhea: FODMAPS for treatment?
Publication Year: 2025 Source: Curr Opin Clin Nutr Metab Care PMID: 40657742
PURPOSE OF REVIEW: To examine in the light of recent data whether diets low in FODMAPs (a now classic exclusion diet for treatment for IBS: irritable bowel syndrome) have shown interest/efficacy in diseases of the digestive tract (beyond IBS) manifesting as diarrhea. RECENT FINDINGS: Very little good quality data or …
Practical Tips for Diagnosis and Management of Concomitant Inflammatory Spondyloarthritis and Inflammatory Bowel Disease
Publication Year: 2025 Source: Curr Gastroenterol Rep PMID: 40658153
PURPOSE OF REVIEW: The goal of this review is to provide practical guidance for gastroenterologists regarding diagnosis and management of inflammatory bowel disease associated spondyloarthritis. RECENT FINDINGS: While there is limited data regarding optimal management approaches, we summarize available screening tools along with classification and consensus criteria that can be …
Identification of a 10-species microbial signature of inflammatory bowel disease by machine learning and external validation
Publication Year: 2025 Source: Cell Regen PMID: 40658318
Genetic and microbial factors influence inflammatory bowel disease (IBD), prompting our study on non-invasive biomarkers for enhanced diagnostic precision. Using the XGBoost algorithm and variable analysis and the published metadata, we developed the 10-species signature XGBoost classification model (XGB-IBD10). By using distinct species signatures and prior machine and deep learning …
Edible Hybrid Sporopollenin Microspheres with Nanozyme for Oral Treatment of Inflammatory Bowel Disease
Publication Year: 2025 Source: ACS Appl Mater Interfaces PMID: 40658511
Inflammatory bowel disease (IBD) is a chronic recurrent inflammatory disease, and the treatment of IBD remains a challenge due to its limited therapeutic efficiency, high side effects, and high cost. It has been demonstrated that sporopollenin microcapsules derived from a variety of pollen species could function as efficient drug carriers …
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