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Prednisolone pharmacokinetics in dogs with protein-losing enteropathy
Publication Year: 2025 Source: J Vet Intern Med PMID: 39715442
BACKGROUND: It is unknown if glucocorticoid malabsorption contributes to the approximate 50% treatment failure rate in dogs with protein-losing enteropathy (PLE). OBJECTIVE: To compare pharmacokinetics (PK) of orally administered prednisolone in dogs with PLE vs healthy controls. ANIMALS: Fourteen dogs with well-characterized PLE and 7 control dogs. METHODS: Prospective case-controlled …
Dysbiosis exists in unaffected relatives of inflammatory bowel disease (IBD): emphasising the critical phases in the developmental trajectory of gut microbiota
Publication Year: 2025 Source: Gut PMID: 39715670 DOI: 10.1136/gutjnl-2024-333425
No Abstract
Are histamine-2 receptor antagonists a reasonable comparator: comparing apples and apples?
Publication Year: 2025 Source: Gut PMID: 39715671 DOI: 10.1136/gutjnl-2024-334496
No Abstract
[Efficient treatment of mild Crohn's disease and mild ulcerative colitis]
Publication Year: 2025 Source: Inn Med (Heidelb) PMID: 39715834
No Abstract
Augmenting anti-inflammatory macrophage function in colitis: a neuroimmune mechanism to drive intestinal wound repair
Publication Year: 2025 Source: Am J Physiol Gastrointest Liver Physiol PMID: 39716372 DOI: 10.1152/ajpgi.00368.2024
No Abstract
Diverse domains of raspberry pectin: critical determinants for protecting against IBDs
Publication Year: 2025 Source: Food Funct PMID: 39716902 DOI: 10.1039/d4fo03363a
Inflammatory bowel diseases (IBDs), including Crohn's disease (CD) and ulcerative colitis (UC), are chronic conditions characterized by periods of intestinal inflammation and have become global diseases. Dietary pectins have shown protective effects on IBD models. However, the development of pectin-based diet intervention for IBD individuals requires knowledge of both the …
Safety and Effectiveness of Glucagon-like Peptide-1 Receptor Agonists in Inflammatory Bowel Disease
Publication Year: 2025 Source: Am J Gastroenterol PMID: 39717004 DOI: 10.14309/ajg.0000000000003208
INTRODUCTION: The safety and effectiveness of glucagon-like peptide receptor agonists (GLP1-RA) in patients with inflammatory bowel disease (IBD) are poorly understood. METHODS: Patients with IBD treated with GLP1-RA were retrospectively identified for outcomes of adverse events, weight change, and clinical, endoscopic, and biomarker response. RESULTS: Among a total of 120 …
Histopathologic and Antioxidant Regulatory Effects of Different Doses of Thymoquinone Against 2,4,6-Trinitrobenzene Sulfonic Acid-Induced Experimental Colitis in Rats
Publication Year: 2025 Source: J Biochem Mol Toxicol PMID: 39717935 DOI: 10.1002/jbt.70110
The aim of this study was to investigate the potential role of thymoquinone in the treatment of inflammatory bowel disease (IBD) by examining the effects of various doses of thymoquinone on histopathological changes, oxidative stress, and antioxidant markers in basic stamens in a 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis model in …
Intestinal ultrasound at diagnosis of pediatric inflammatory bowel disease compared to endoscopy
Publication Year: 2025 Source: J Pediatr Gastroenterol Nutr PMID: 39718128 DOI: 10.1002/jpn3.12444
OBJECTIVES: Intestinal ultrasound (IU) has emerged as an alternative to detect bowel wall inflammation. The aim of this study was to compare IU findings to clinical disease, fecal calprotectin (FC), and endoscopic findings in newly diagnosed pediatric inflammatory bowel disease (IBD) patients. METHODS: This study was a 1-year, single-center, prospective …
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