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Group-Delivered Mindfulness-Based Cognitive Therapy to Reduce Psychological Distress and Improve Sleep in Patients With Inflammatory Bowel Diseases: A Multicenter Randomized Controlled Trial (MindIBD)
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40658641
BACKGROUND: Many patients with inflammatory bowel disease (IBD) suffer from psychological distress, sleep disturbances, fatigue, and a reduced quality of life-even during remission. Mindfulness-Based Cognitive Therapy (MBCT) has been effective in other populations, and therefore it may also benefit IBD patients. The primary objective was to evaluate the effectiveness of …
Genetically engineered sericin hydrogels for the delivery of human adiponectin in treating ulcerative colitis in mice
Publication Year: 2025 Source: Acta Biomater PMID: 40659150
Ulcerative colitis (UC) is one type of inflammatory bowel diseases, and adiponectin (APN) is a potential therapeutic protein drug for treating UC. However, source and targeted delivery of APN to improve its effectiveness and bioavailability remain challenges. Here, we report a strategy to develop a sericin hydrogel (rhAPN-sh) through genetically …
A novel triazole derivative ameliorates ulcerative colitis by targeting PPAR gamma
Publication Year: 2025 Source: Int J Biol Macromol PMID: 40659263
Ulcerative colitis (UC) is a chronic inflammatory bowel disease that remains incurable. Although current medications can alleviate symptoms, treatment still faces major challenges such as side effects and drug resistance. Therefore, the development of new drugs is urgently needed. This study introduces a novel 1,2,3-triazole derivative, 5-phenyl-1-(p-tolyl)-1H-1,2,3-triazole (PPTT), which alleviates …
GETECCU POSITION PAPER ON FRAGILITY, ADVANCED AGE AND INFLAMMATORY BOWEL DISEASE
Publication Year: 2025 Source: Gastroenterol Hepatol PMID: 40659288
Frailty is a state of vulnerability characterised by a decrease in physiological reserve and the ability to respond to stress, which increases the risk of complications, adverse effects of treatments and functional decline. Assessing frailty allows the biological age of patients to be determined, beyond their chronological age, providing a …
Week 2 remission with vedolizumab as a predictor of long-term remission in patients with ulcerative colitis: a multicenter, retrospective, observational study
Publication Year: 2025 Source: Intest Res PMID: 40659337
BACKGROUND/AIMS: Vedolizumab (VDZ), a gut-selective monoclonal antibody for ulcerative colitis (UC) treatment, has no established biomarkers or clinical features that predict long-term remission. Week 2 remission, a potential predictor of long-term remission, could inform maintenance treatment strategy. METHODS: This retrospective, observational chart review included patients with UC in Japan who …
Efficacy and safety of carotegrast methyl in active ulcerative colitis: a real-world prospective cohort study
Publication Year: 2025 Source: Intest Res PMID: 40659338
BACKGROUND/AIMS: Carotegrast methyl, an oral alpha4-integrin inhibitor, was recently approved for the treatment of active ulcerative colitis (UC). However, real-world data regarding its efficacy and safety remain scarce. This study aimed to assess the clinical effectiveness and safety profile of carotegrast methyl in patients with active UC. METHODS: Patients with …
Cross-ethnic evaluation of gut microbial signatures reveal increased colonization with oral pathobionts in the north Indian inflammatory bowel disease cohort
Publication Year: 2025 Source: Intest Res PMID: 40659339
BACKGROUND/AIMS: Inflammatory bowel disease (IBD) has become a global health concern. With the growing evidence of the gut microbiota's role in IBD, studying microbial compositions across ethnic cohorts is essential to identify unique, populationspecific microbial signatures. METHODS: We analyzed stool samples and clinical data from 254 IBD patients (226 ulcerative …
Properdin, transcortin and HGFAC are novel plasma biomarkers in canine chronic inflammatory enteropathies from active disease to remission
Publication Year: 2025 Source: Sci Rep PMID: 40659816
Canine chronic inflammatory enteropathies (CCIE) is a group of intestinal inflammatory conditions causing chronic or relapsing gastrointestinal symptoms. Accurate diagnosis, treatment and monitoring remain challenging, necessitating novel diagnostic tools. This study aims to investigate the plasma proteome of ten dogs with histologically confirmed CCIE during active disease and clinical remission …
Faecalibacterium prausnitzii enhances intestinal IgA response by host-microbe derived inecalcitol in colitis
Publication Year: 2025 Source: BMC Med PMID: 40660288
BACKGROUND: Faecalibacterium prausnitzii plays a crucial role in ulcerative colitis (UC) remission, but its action mechanism is unknown. Here, we aimed to explore the potential mechanisms focusing on the interaction of F. prausnitzii with host immune response and its potential modulation on gut microbiome. METHODS: RNA-seq analysis together with 16S …
Acid-Enzyme Derived Agarotriose Facilitates Anti-Inflammatory Activity for Dextran Sulfate Sodium-Induced Colitis Alleviation as a Food Supplement
Publication Year: 2025 Source: J Agric Food Chem PMID: 40661034
Ulcerative colitis (UC) is a chronic inflammatory bowel disease with inadequate therapeutic options and has a significant impact on patient quality of life. We optimized the preparation of agarotriose (A3), a functional oligosaccharide, and assessed its health-promoting potential in a dextran sulfate sodium-induced UC mouse model. The beneficial effects of …
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