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Incidence, Disease Burden, and Clinical Presentation of Patients Newly Diagnosed With Inflammatory Bowel Disease in a Population-Based Inception Cohort
Publication Year: 2025 Source: J Crohns Colitis PMID: 39565294 DOI: 10.1093/ecco-jcc/jjae176
BACKGROUND AND AIMS: Emerging data indicate a stabilizing incidence of inflammatory bowel diseases (IBD), including ulcerative colitis (UC), Crohn's disease (CD), and IBD unclassified (IBDU) in Western countries. We aimed to investigate the incidence of IBD, its initial clinical presentation, and patient-reported burden. METHODS: Copenhagen IBD Inception Cohort is a …
Partial Enteral Nutrition in the Management of Crohn's Disease: A Systematic Review and Meta-Analysis
Publication Year: 2025 Source: J Crohns Colitis PMID: 39565924
BACKGROUND: Exclusive enteral nutrition is an established treatment for active Crohn's disease but the role of partial enteral nutrition (PEN) in the broader management of the disease is less clear. This systematic review and meta-analysis reviewed the literature on the role of PEN in Crohn's disease management. METHODS: This review …
The malic acid inhibiting inflammation in ankylosing spondylitis by interfering M1 macrophage polarization
Publication Year: 2025 Source: Int Immunopharmacol PMID: 39566386 DOI: 10.1016/j.intimp.2024.113653
Ankylosing spondylitis (AS) is a motor system immune disease with significant genetic characteristics, resulting in joint fusion, deformity, rigidity, seriously affecting the quality of life of patients. Inflammatory bowel disease (IBD), characterized by intestinal mucosal damage and inflammatory changes, the most common extra-articular manifestation of AS. Due to the limitations …
Intestinal Ultrasound in Common Gastrointestinal Disorders: An Evidence-Based Approach
Publication Year: 2025 Source: Med Clin North Am PMID: 39567092
No Abstract
The improvement of a refractory enterocutaneous fistula with colchicine in a patient with Crohn's disease who had an MEFV gene mutation
Publication Year: 2025 Source: Clin J Gastroenterol PMID: 39567438
No Abstract
PANoptosis-related genes: Molecular insights into immune dysregulation in ulcerative colitis
Publication Year: 2025 Source: J Gastroenterol Hepatol PMID: 39568189
No Abstract
Heat-killed Lacticaseibacillus paracasei 6235 is more effective than live on DSS-induced colitis via modulation of intestinal microbiota and MAPK/NF-κB signaling pathways
Publication Year: 2025 Source: Food Funct PMID: 39569739
This study compared the protective effects of both live Lacticaseibacillus paracasei 6235 (LLP 6235) and heat-killed Lacticaseibacillus paracasei 6235 (HK-LP 6235) on ulcerative colitis. Using a dextran sulfate sodium (DSS)-induced colitis mouse model, we evaluated physiological state, colon tissue integrity, inflammatory factors, tight junction (TJ) proteins, and intestinal microbiota variations. …
Development of Time-Aggregated Machine Learning Model for Relapse Prediction in Pediatric Crohn's Disease
Publication Year: 2025 Source: Clin Transl Gastroenterol PMID: 39569890
INTRODUCTION: Pediatric Crohn's disease (CD) easily progresses to an active disease compared with adult CD, making it important to predict and minimize CD relapses. However, prediction of relapse at various time points (TPs) during pediatric CD remains understudied. We aimed to develop a real-time aggregated model to predict pediatric CD …
Impact of HLADQA1*05 and HLADQA1*03 on Safety and Loss of Response to Anti-Tumor Necrosis Factor in Patients With Inflammatory Bowel Disease
Publication Year: 2025 Source: J Crohns Colitis PMID: 39570188
BACKGROUND: HLADQA1*05 is recently associated with heightened immunogenicity to anti-tumor necrosis factor (TNFalpha). We aimed to determine whether HLADQ1*05 is a risk factor for primary non-response, loss of response (LOR), or adverse events (AE) to first-line anti-TNFalpha in patients with inflammatory bowel disease. METHODS: We performed a retrospective observational study …
Metabolomics combined with network pharmacology revealed a paradigm for determining the mechanism underlying the metabolic action of Gegen Qinlian Decoction amelioration of ulcerative colitis in mice
Publication Year: 2025 Source: J Chromatogr B Analyt Technol Biomed Life Sci PMID: 39571215
No Abstract
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