Research Articles Library
Literature Analysis Tools
Advanced Search
Filter by PMID, year, source, DOI and other criteria
Literature Analysis
Analyze research trends and hotspots
Batch Export
Export search results to Excel/PDF
Sulfide Quinone Oxidoreductase Alleviates Acute Ulcerative Colitis by Regulating Mitochondrial Dysfunction
Publication Year: 2025 Source: MedComm (2020) PMID: 40661137
Alteration in mitochondrial function within intestinal epithelial cells were closely related to inflammatory bowel disease (IBD) progression. Sulfide quinone oxidoreductase (SQOR), located in the inner mitochondria membrane, is a crucial enzyme in sulfide metabolism. Here, we observed that SQOR was downregulated during colitis. Intestinal epithelial cells specific knockout of SQOR …
Immune Microenvironment Characterization and Machine Learning-Guided Identification of Diagnostic Biomarkers for Ulcerative Colitis
Publication Year: 2025 Source: J Inflamm Res PMID: 40661186
BACKGROUND: Ulcerative colitis (UC) is a chronic inflammatory bowel disease hallmarked by dysregulated immune responses. Current treatments often show limited efficacy, highlighting the need for novel diagnostic and therapeutic approaches. METHODS: RNA-Seq data from 495 UC patients and 320 controls (training dataset) and 389 UC patients and 209 controls (testing …
Artificial intelligence in inflammatory bowel disease endoscopy - a review of current evidence and a critical perspective on future challenges
Publication Year: 2025 Source: Therap Adv Gastroenterol PMID: 40661220
Inflammatory bowel disease (IBD) is a chronic and relapsing immune-mediated condition with a rising global prevalence. Endoscopic diagnosis, monitoring and surveillance currently depend on individual endoscopists, introducing subjectivity, variability, delays and potential diagnostic discrepancies. Artificial intelligence (AI) is poised to transform these processes. To date, most AI applications have focused …
Mechanostimulatory cues determine intestinal fibroblast fate and profibrotic remodeling in a physiodynamic human gut-on-a-chip
Publication Year: 2025 Source: bioRxiv PMID: 40661399
Biomechanical cues, including shear stress and mechanical strain, are key regulators of intestinal cellular behavior, yet their mechanostimulatory impact on fibroblasts responses during early fibrotic remodeling remains poorly understood. Using a bioengineered gut-on-a-chip model, we independently modulated flow and mechanical strain to assess fibroblast dynamics under intact or impaired epithelial …
Single-cell multiomics identifies both shared and unique features of immune dysfunction in Parkinson's disease and inflammatory bowel disease colon, plasma and stool
Publication Year: 2025 Source: bioRxiv PMID: 40661410
Parkinson's disease (PD) is the fastest growing neurodegenerative disease in the world (1) . Gastrointestinal (GI) dysfunction can occur decades before motor impairments and in up to 80% of individuals living with PD (2,3,4) . We investigated peripheral relationships that may underlie mechanisms along the gut-blood axis that contribute to …
Bone marrow mesenchymal stem cell-derived exosomes alleviate DSS-induced inflammatory bowel disease in mice through inhibiting intestinal epithelial cell pyroptosis via delivery of TSG-6
Publication Year: 2025 Source: Front Immunol PMID: 40661945
BACKGROUND: Inflammatory bowel disease (IBD), characterized by chronic intestinal inflammation and epithelial barrier dysfunction, remains a therapeutic challenge due to the limitations of current treatments, including drug resistance and invasive surgical risks. Emerging evidence implicates intestinal epithelial cells (IECs) pyroptosis as a key contributor to IBD progression. Bone marrow mesenchymal …
PD-L1 deficiency exacerbates colitis severity by remodeling gut microbiota in inflammatory bowel disease
Publication Year: 2025 Source: Front Immunol PMID: 40661950
BACKGROUND: Inflammatory bowel disease (IBD) is a chronic autoimmune disorder driven by gut microbiota dysbiosis. As an essential immune checkpoint, Programmed death-ligand 1 (PD-L1) has been implicated in modulating gut microbiota composition. However, the precise role of PD-L1 in shaping metagenomic profiles during IBD-associated colitis remains unexplored. METHODS: DSS-induced colitis …
Cellular senescence defining the disease characteristics of Crohn's disease
Publication Year: 2025 Source: Front Immunol PMID: 40661957
BACKGROUND: Crohn's disease (CD) is a complex and heterogeneous inflammatory disease whose most important feature is immune dysregulation. As a basic cell response, cellular senescence (CS) can regulate the immune response involved in a variety of inflammatory diseases. However, the role of CS in the pathogenesis and diagnosis prediction of …
Effectiveness and safety of non-pharmacological therapies for the treatment of inflammatory bowel disease: a network meta-analysis
Publication Year: 2025 Source: Front Med (Lausanne) PMID: 40662074
BACKGROUND: Inflammatory bowel disease (IBD), encompassing both Crohn's disease (CD) and ulcerative colitis (UC), is a chronic, inflammatory, and immune-mediated disorder of the gastrointestinal tract. If left inadequately treated, IBD can lead to disease progression, resulting in severe long-term complications, including irreversible structural damage to the intestinal tissues. While clinical …
Sexual function in immune-mediated inflammatory diseases: A biopsychosocial systematic review
Publication Year: 2025 Source: J Health Psychol PMID: 40662325
This systematic review evaluates the impact of immune-mediated inflammatory diseases (IMIDs) on sexual function and health-related quality of life (HR-QoL) in both men and women, from a biopsychosocial perspective. Diseases assessed include rheumatoid arthritis, psoriatic arthritis, psoriasis, ankylosing spondylitis, Crohn's disease, and ulcerative colitis. A total of 42 studies were …
Need more literature?
The current database contains 98453 research articles. If you need to search for more literature or perform AI analysis, please use our knowledge acquisition module or explore external literature resources.
External Resources: Access comprehensive literature databases worldwide