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Susceptibility to inflammatory bowel diseases promotes invasive carcinomas in a murine model of ATF6-driven colon cancer
Publication Year: 2025 Source: J Crohns Colitis PMID: 40662399
BACKGROUND AND AIMS: Chronic inflammation in inflammatory bowel disease (IBD) patients represents a risk factor for developing colitis-associated cancer (CAC). We previously linked the endoplasmic reticulum unfolded protein response (UPRER) signal transducer activating transcription factor 6 (ATF6) with spontaneous microbiota-dependent colonic adenoma development in mice expressing epithelial-specific activated ATF6 (nATF6IEC). …
SAR Consensus Recommendations for Defining Small Bowel Crohn Disease Strictures at CT and MR Enterography
Publication Year: 2025 Source: Radiology PMID: 40662968
More than half of patients with Crohn disease will develop strictures. Strictures are areas of bowel luminal narrowing composed of a combination of inflammatory cells, muscular hypertrophy, and fibrosis. Most patients with strictures eventually require endoscopic or surgical intervention. This article reviews small bowel Crohn disease stricture histopathology, current imaging …
Systemic Biologics Have Similar Safety to Vedolizumab in Inflammatory Bowel Disease Patients Following Liver Transplantation
Publication Year: 2025 Source: Aliment Pharmacol Ther PMID: 40663036
BACKGROUND AND AIMS: 'Gut-specific' biologics are associated with fewer infectious complications than 'systemic' biologics in inflammatory bowel disease (IBD) which represents an important consideration in transplant recipients. This study evaluated the safety of combining transplant immunosuppression with 'gut-specific' versus 'systemic' biologics to manage IBD following liver transplantation (LTx). METHODS: A …
NFAT5 dictates crosstalk between intestinal epithelial regenerative capacity and microbiota in murine colitis models
Publication Year: 2025 Source: J Clin Invest PMID: 40663408
Hypertonic and hyperosmolar stimuli frequently pose challenges to the intestinal tract. Therefore, a resilient epithelial barrier is essential for maintaining gut homeostasis in the presence of osmotic perturbations. NFAT5, an osmosensitive transcription factor, primarily maintains cellular homeostasis under hypertonic conditions. However, the osmoprotective role of NFAT5 in enterocyte homeostasis is …
The biology of interleukin-6 family cytokines is regulated by glycosylation
Publication Year: 2025 Source: Biochem J PMID: 40663802
Cytokines of the interleukin-6 (IL-6) family are important soluble mediators with crucial roles in developmental processes, tissue homeostasis, regeneration, and immune cell differentiation. Overshooting activities of IL-6 and other cytokines are found in all inflammatory diseases, making them attractive therapeutic targets for the treatment of patients with rheumatoid arthritis or …
Therapeutic effects of D-cycloserine in mouse models of IBD and CAC: Targeting NLRP3 inflammasome and intestinal barrier integrity
Publication Year: 2025 Source: Int Immunopharmacol PMID: 40663810
D-Cycloserine (DCS), a broad-spectrum antibiotic and NMDA receptor modulator, exhibits immunomodulatory effects beyond its known neurological and antimicrobial functions. This study investigated DCS's therapeutic potential in inflammatory bowel disease (IBD) and colitis-associated colorectal cancer (CAC) using in vitro and in vivo models. In lipopolysaccharide (LPS)-stimulated NCM460 cells, DCS inhibited NLRP3 …
IGF2BP2 alleviates ulcerative colitis by inhibiting MEK1/2 and ERK1/2 signaling pathways in intestinal epithelial cells via m6A-dependent stabilization of LGI4 mRNA
Publication Year: 2025 Source: Int Immunopharmacol PMID: 40663812
BACKGROUND: Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by sustained epithelial damage and heightened immune activation, with intestinal epithelial cells playing a pivotal role in its pathogenesis. N6-methyladenosine (m6A) methylation, a prevalent RNA epigenetic modification, has garnered increasing attention for its potential involvement in UC progression. However, …
Comment on "Vascular complications in hospitalized patients with inflammatory bowel disease and acute gastroenteritis and colitis"
Publication Year: 2025 Source: Dig Liver Dis PMID: 40664598
No Abstract
Long-term efficacy of therapeutic drug monitoring-guided optimization of ustekinumab maintenance therapy for Crohn's disease patients
Publication Year: 2025 Source: Sci Rep PMID: 40664796
Long-term remission in Crohn's disease (CD) remains challenging. While ustekinumab effectively induces remission, strategies to enhance its maintenance efficacy are urgently needed. This study evaluated therapeutic drug monitoring (TDM)-guided ustekinumab optimization for sustained CD management. A retrospective observational study was conducted involving 158 patients [TDM: n = 87, age(16 39), …
Exploring the health benefits of gut microbiota metabolites on combating ulcerative colitis via network pharmacology, bioinformatics and molecular docking
Publication Year: 2025 Source: Sci Rep PMID: 40664846
Ulcerative colitis (UC) is a leading health challenge worldwide. The evidence of the benefits of gut microbiota metabolites for the treatment of ulcerative colitis is accumulating, but the underlying mechanism remains to be further elucidated. Hence, the aim of this study was to decipher the role of gut microbiota metabolites …
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