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Anti-Inflammatory Effects of Hydrogen Sulfide in Axes Between Gut and Other Organs
Publication Year: 2025 Source: Antioxid Redox Signal PMID: 39655451 DOI: 10.1089/ars.2023.0531
Significance: Hydrogen sulfide (H(2)S), a ubiquitous small gaseous signaling molecule, plays a critical role in various diseases, such as inflammatory bowel disease (IBD), rheumatoid arthritis (RA), ischemic stroke, and myocardial infarction (MI) via reducing inflammation, inhibiting oxidative stress, and cell apoptosis. Recent Advances: Uncontrolled inflammation is closely related to pathological …
TNBS colitis induces architectural changes and alpha-synuclein overexpression in mouse distal colon: A morphological study
Publication Year: 2025 Source: Cell Tissue Res PMID: 39656240 DOI: 10.1007/s00441-024-03932-4
Alpha-synuclein (alpha-syn) is widely expressed in presynaptic neuron terminals, and its structural alterations play an important role in the pathogenesis of Parkinson's disease (PD). Aggregated alpha-syn has been found in brain, in the peripheral nerves of the enteric nervous system (ENS) and in the intestinal neuroendocrine cells during synucleinopathies and …
Multi-Omics Biomarkers for Predicting Efficacy of Biologic and Small-Molecule Therapies in Adults With Inflammatory Bowel Disease: A Systematic Review
Publication Year: 2025 Source: United European Gastroenterol J PMID: 39656426
No Abstract
Mediators of Filgotinib Treatment Effects in Ulcerative Colitis: Exploring Circulating Biomarkers in the Phase 2b/3 SELECTION Study
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 39656830
BACKGROUND: We utilized patient samples from the large, phase 2b/3 SELECTION trial to identify circulating biomarkers of ulcerative colitis (UC) and potential early mediators of filgotinib treatment effects. METHODS: Samples were collected at baseline and during the induction phase of the SELECTION trial. Evaluated biomarkers comprised serum and stool proteins …
Modifiable Psychological Factors are Associated With Clusters of Pain, Fatigue, Fecal Incontinence, and Irritable Bowel Syndrome-Type Symptoms in Inflammatory Bowel Disease: A Latent Profile Analysis
Publication Year: 2025 Source: J Crohns Colitis PMID: 39656929 DOI: 10.1093/ecco-jcc/jjae183
BACKGROUND: Inflammatory bowel disease (IBD) causes fatigue, pain, and fecal urgency/incontinence symptoms. Identifying symptom profile subgroups and related psychological correlates might enable earlier intervention and more effective tailored treatment pathways. METHODS: This study was nested within a randomized controlled trial of a digital symptom intervention for people with IBD (n …
Decreased Levels of Atmospheric Pollution and Reduced Prevalence of Inflammatory Bowel Diseases in Europe
Publication Year: 2025 Source: J Crohns Colitis PMID: 39656958
No Abstract
Autologous Microfragmented Adipose Tissue Injection in Refractory Complex Crohn's Perianal Fistulas: Long-Term Results at 6.7 Years Mean Follow-up
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 39657028
BACKGROUND: Nowadays, there is a clear need for new viable therapeutic options to face complex perianal Crohn's disease (PCD). Results of our previous pilot study demonstrated the efficacy and safety of local injection of autologous microfragmented adipose tissue (MFat) in this setting. This study aims to evaluate the long-term follow-up …
Dexamethasone Upregulates the Expression of the Human SLC26A3 (DRA, Down-Regulated in Adenoma) Transporter (an IBD Susceptibility Gene) in Intestinal Epithelial Cells and Attenuates Gut Inflammation
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 39657154 DOI: 10.1093/ibd/izae271
BACKGROUND: Down-Regulated in Adenoma (DRA) plays a critical role in intestinal chloride absorption and a decrease in its expression is a key event in diarrheal disorders. Recently, DRA has emerged as an Inflammatory Bowel Disease (IBD) susceptibility gene. Therefore, the strategies to upregulate DRA expression are potentially novel approaches to …
Anti-integrin αvβ6 Antibodies Predict Pouchitis in Patients With Ulcerative Colitis After Restorative Proctocolectomy With Ileal Pouch-Anal Anastomosis
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 39657162
BACKGROUND: Pouchitis is the most common complication of restorative proctocolectomy (RPC) with ileal pouch-anal anastomosis (IPAA) in patients with ulcerative colitis (UC). We previously reported the presence of anti-integrin alphavbeta6 antibodies in the serum of patients with UC. This study investigated the association between anti-integrin alphavbeta6 antibodies and the development …
Modified Jiaoqi Powder enhances epithelial autophagy against TNF-triggered apoptosis in chronic ulcerative colitis
Publication Year: 2025 Source: Phytomedicine PMID: 39657404
No Abstract
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