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Diverse Phenotypes, Consistent Treatment: A Study of 30 997 South Asian and White Inflammatory Bowel Disease Patients Using the UK Inflammatory Bowel Disease BioResource
Publication Year: 2025 Source: J Crohns Colitis PMID: 39657589 DOI: 10.1093/ecco-jcc/jjae186
BACKGROUND: Studies in the UK and North America have suggested a distinct disease profile in South Asians compared to that of White populations. Disparities in the medical and surgical management of IBD in minority ethnic groups (including Black Americans and Asians) in the US have been shown, while data from …
Disparities in Gender and Race Representation Among Authors of Inflammatory Bowel Disease Clinical Trials
Publication Year: 2025 Source: J Crohns Colitis PMID: 39657593 DOI: 10.1093/ecco-jcc/jjae184
BACKGROUND AND AIMS: Female physicians, particularly those from minority populations, are significantly underrepresented in research authorship in gastroenterology. This underrepresentation negatively impacts their career progression. This study analyses gender and race representation trends in published clinical trials in inflammatory bowel disease (IBD) and associated factors. METHODS: Inflammatory bowel disease clinical …
MIP4IBD: An Easy and Rapid Genotyping-by-Sequencing Assay for the Inflammatory Bowel Diseases Risk Loci
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 39657915 DOI: 10.1093/ibd/izae289
BACKGROUND: Inflammatory bowel diseases (IBD) are polygenic, with many genetic variants contributing to disease risk. Knowing the genotype of specific variants or calculating a combined genetic risk score benefits translational and functional research. To address this, we developed MIP4IBD, a flexible and cost-effective genotyping-by-sequencing assay using molecular inversion probes (MIPs). …
Tofacitinib Versus Vedolizumab Among Bio-naive Patients With Ulcerative Colitis: A Real-World Propensity-Weighted Comparison
Publication Year: 2025 Source: J Crohns Colitis PMID: 39659234
BACKGROUND AND AIMS: Over the last decade, treatment options for moderate-to-severe ulcerative colitis (UC) have expanded. However, comparative studies between these agents are limited, especially among biologic-naive patients. We aimed to compare the persistence, effectiveness, and safety of tofacitinib and vedolizumab as the first advanced treatment for patients with UC. …
Disparities in Peripheral Artery Disease-related Mortality in Chronic Inflammatory Disease in the United States from 1999 to 2020
Publication Year: 2025 Source: Curr Cardiol Rev PMID: 39660527
INTRODUCTION: Peripheral arterial disease (PAD) is a marker of significant atherosclerotic cardiovascular disease and is associated with greater healthcare burden and worse prognosis in individuals with chronic inflammatory disease (CID). We aimed to investigate temporal trends and disparities of PAD-related mortality in populations with CID from 1999-2020 across six common …
A bibliometric analysis of inflammatory bowel disease research in the Arab world
Publication Year: 2025 Source: Saudi J Gastroenterol PMID: 39660608 DOI: 10.4103/sjg.sjg_303_24
BACKGROUND: The prevalence of inflammatory bowel disease (IBD) continues to increase worldwide, including in the Arab world. This study investigates IBD research output in Arab countries from 2009 to 2023, alongside prevalence and incidence trends. METHODS: We utilized bibliometric analysis with data from Clarivate Analytics, the Institute for Health Metrics …
Long-Term Outcomes of an Infliximab-First Versus Vedolizumab-First Treatment Strategy in Biologic-Naïve Patients With Ulcerative Colitis
Publication Year: 2025 Source: Aliment Pharmacol Ther PMID: 39660680
No Abstract
American ginseng vesicles loaded hyaluronic acid hydrogel for ulcerative colitis
Publication Year: 2025 Source: Int J Biol Macromol PMID: 39662541
No Abstract
Exclusion diet and fasting practices in patients with inflammatory bowel disease: Impact on nutritional status
Publication Year: 2025 Source: Clin Nutr ESPEN PMID: 39662590 DOI: 10.1016/j.clnesp.2024.12.010
BACKGROUND: Undernutrition is purportedly highly prevalent in inflammatory bowel diseases (IBD). While several risk factors have been identified, the impact of widespread eating behaviors such as food exclusions and therapeutic fasting practices has not been evaluated. There are limited data on the prevalence of undernutrition diagnosed according to internationally recognized …
Intestinal mucus barrier: A potential therapeutic target for IBD
Publication Year: 2025 Source: Autoimmun Rev PMID: 39662652 DOI: 10.1016/j.autrev.2024.103717
Intestinal mucus, a viscoelastic medium with mucin2 (MUC2) as its main component, covers the surface of intestinal epithelial cells and protects the intestine from invasion, forming the first barrier of the intestinal tract. Unlike the small intestine, where the mucus layer is a single layer, the colonic mucus layer can …
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