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The flaming and pulled up anorectal line: Ulcerative colitis-associated squamous metaplasia of the lower rectum
Publication Year: 2025 Source: Clin Res Hepatol Gastroenterol PMID: 39662731
No Abstract
Unravelling metabolite-microbiome interactions in inflammatory bowel disease through AI and interaction-based modelling
Publication Year: 2025 Source: Biochim Biophys Acta Mol Basis Dis PMID: 39662756 DOI: 10.1016/j.bbadis.2024.167618
Inflammatory Bowel Diseases (IBDs) are chronic inflammatory disorders of the gastrointestinal tract and colon affecting approximately 7 million individuals worldwide. The knowledge of specific pathology and aetiological mechanisms leading to IBD is limited, however a reduced immune system, antibiotic use and reserved diet may initiate symptoms. Dysbiosis of the gut …
Therapeutic Agents and Patient Characteristics Affecting Metabolism of Thiopurines in Patients with Inflammatory Bowel Disease
Publication Year: 2025 Source: Fukushima J Med Sci PMID: 39662937
OBJECTIVES: In inflammatory bowel disease therapy, thiopurines have been essential. However, several reports have investigated factors affecting thiopurine metabolism to date. This study investigated factors affecting intracellular concentrations of 6-thioguanine nucleotide (6-TGN) and 6-methylmercaptopurine (6-MMP) in a real-world setting. METHODS: Between May 2013 and October 2021 in one institution, 44 …
Usefulness of Fecal Calprotectin Measurement in a Pediatric Patient with Crohn's Disease
Publication Year: 2025 Source: Fukushima J Med Sci PMID: 39662938
Acute pancreatitis in children in Japan is often caused by an anatomical abnormality of the pancreatic and bile duct, resulting in fever, abdominal pain, vomiting, diarrhea, and other symptoms. Crohn's disease, however, is a chronic granulomatous inflammatory bowel disease with ulcerative lesions of the intestinal tract of unknown cause that …
SAGES guidelines for the management of comorbidities relevant to metabolic and bariatric surgery
Publication Year: 2025 Source: Surg Endosc PMID: 39663246
No Abstract
Integrative multi-omics reveals the mechanism of ulcerative colitis treated with Ma-Mu-Ran antidiarrheal capsules
Publication Year: 2025 Source: Rapid Commun Mass Spectrom PMID: 39663538
RATIONALE: Ulcerative colitis (UC) is a chronic inflammatory gastrointestinal disease typically coexisting with intestinal microbiota dysbiosis, oxidative stress, and an inflammatory response. Although its underlying mechanism of action is unclear, Ma-Mu-Ran Antidiarrheal Capsules (MMRAC) have demonstrated significant therapeutic efficacy for UC. METHODS: The mechanism of action of MMRAC in the …
Carbohydrate Deacetylase Unique to Gut Microbe Bacteroides Reveals Atypical Structure
Publication Year: 2025 Source: Biochemistry PMID: 39663570 DOI: 10.1021/acs.biochem.4c00519
Bacteroides are often the most abundant, commensal species in the gut microbiome of industrialized human populations. One of the most commonly detected species is Bacteroides ovatus. It has been linked to benefits like the suppression of intestinal inflammation but is also correlated with some autoimmune disorders, for example irritable bowel …
Identifying Risk Factors of Major Adverse Cardiac Events in Patients With Ulcerative Colitis: A Retrospective Japanese Claims Data Analysis
Publication Year: 2025 Source: J Gastroenterol Hepatol PMID: 39663909
No Abstract
How Does Inflammatory Bowel Disease Impact Outcomes and Costs of Care Following Primary 1- to 2-level Lumbar Fusion for Degenerative Lumbar Disease?
Publication Year: 2025 Source: Clin Spine Surg PMID: 39665427 DOI: 10.1097/BSD.0000000000001688
STUDY DESIGN: Retrospective study. OBJECTIVE: The purpose of this study was to determine whether IBD in patients with degenerative lumbar changes undergoing primary 1-2LF is associated with higher rates of (1) in-hospital length of stay, (2) medical complications, (3) readmissions, and (4) costs of care. SUMMARY OF BACKGROUND DATA: In …
Modifying Our Environment to Improve Outcomes in Inflammatory Bowel Diseases?
Publication Year: 2025 Source: United European Gastroenterol J PMID: 39665504
No Abstract
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