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Unveiling distinctive patterns in pediatric PSC-IBD: Time for a tailored histopathologic index?

Publication Year: 2025 Source: J Pediatr Gastroenterol Nutr PMID: 39670526 DOI: 10.1002/jpn3.12435

No Abstract

Activation of STAT6 in Intestinal Epithelial Cells Predisposes to Gut Inflammation

Publication Year: 2025 Source: Eur J Immunol PMID: 39670708 DOI: 10.1002/eji.202451394

Ulcerative colitis (UC) is an inflammatory bowel disease (IBD) often associated with a Type 2 immune response. Although previous reports hint at a role for signal transducer and activator of transcription (STAT) 6 signaling in non-immune cells, the contribution of STAT6-activation particularly in intestinal epithelial cells (IECs) is still unknown. …

Depletion of key gut bacteria predicts disrupted bile acid metabolism in inflammatory bowel disease

Publication Year: 2025 Source: Microbiol Spectr PMID: 39670752 DOI: 10.1128/spectrum.01999-24

The gut microbiome plays a key role in bile acid (BA) metabolism, where a diversity of metabolic products contribute to human health and disease. In particular, Inflammatory Bowel Disease (IBD) is characterized by a low concentration of secondary bile acids (SBAs), whose transformation from primary bile acids (PBAs) is an …

Expanding Options for Endoscopic Therapy of Strictures in Patients with Inflammatory Bowel Disease: Is Stricturotomy the Best?

Publication Year: 2025 Source: Dig Dis Sci PMID: 39671063

No Abstract

Gender and Sex Differences in Abdominal Pain, Fatigue, And Psychological Symptoms Among Adults with Inflammatory Bowel Disease: A Network Analysis

Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 39671570 DOI: 10.1093/ibd/izae279

BACKGROUND AND AIMS: Individuals with inflammatory bowel disease (IBD) experience a high symptom burden, including abdominal pain, fatigue, anxiety, depression, and sleep disturbances; yet, little is known regarding the relationship between sex and gender on symptoms. We sought to report symptom severity for cisgender men, cisgender women, and transgender and …

Common Variable Immunodeficiency Clinical Manifestations Are Shaped by Presence and Type of Heterozygous NFKB1 Variants

Publication Year: 2025 Source: J Allergy Clin Immunol Pract PMID: 39672378

No Abstract

Period circadian clock 3 is crucial for regulation of IL-22-producing type 3 innate lymphoid cells by flavonoids from Shen Ling Bai Zhu San to alleviate colitis

Publication Year: 2025 Source: Int J Biol Macromol PMID: 39672410 DOI: 10.1016/j.ijbiomac.2024.138730

Type 3 Innate lymphoid cells (ILC3s) functions bear complex response during Inflammatory bowel diseases (IBD). Here, our study first analyzed the main pharmacological components in Shen Ling Bai Zhu San n-butanol extracts (S-Nb), and then explored whether S-Nb administrated immune response of ILC3s, and how it regulates ILC3s. Shen Ling …

Retrograded starch as colonic delivery carrier of taxifolin for treatment of DSS-induced ulcerative colitis in mice

Publication Year: 2025 Source: Int J Biol Macromol PMID: 39672437

No Abstract

Position statement of the Spanish Working Group on Crohn's Disease and Ulcerative Colitis on the use of Telemedicine in Inflammatory Bowel Disease

Publication Year: 2025 Source: Gastroenterol Hepatol PMID: 39672505 DOI: 10.1016/j.gastrohep.2024.502320

Inflammatory Bowel Disease (IBD) is a chronic digestive condition that requires continuous monitoring by healthcare professionals to determine appropriate therapy and manage short- and long-term complications. Telemedicine has become an essential approach for managing chronic conditions such as IBD, improving care accessibility and continuity, decreasing hospitalization rates, and optimizing patient …

Clinical Significance of histologic healing in IBD: Evidence from randomized controlled trials (RCT) and real world (RW) data

Publication Year: 2025 Source: Dig Liver Dis PMID: 39672772 DOI: 10.1016/j.dld.2024.11.009

Histologic mucosal healing (HMH) has emerged as a crucial target in managing inflammatory bowel disease, complementing the established goal of endoscopic mucosal healing. This review evaluates the significance of HMH in both Crohn's disease (CD) and ulcerative colitis (UC). In UC, strong evidence shows that HMH correlates with improved long-term …

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