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Predicted pro-inflammatory high-sensitivity C-reactive protein score and inflammatory bowel disease: a cross-sectional study
Publication Year: 2025 Source: Korean J Intern Med PMID: 40665798
BACKGROUND/AIMS: The role of pro-inflammatory factors in the pathogenesis of inflammatory bowel diseases (IBD), is not well understood. This study investigated the association between the predicted pro-inflammatory high-sensitivity C-reactive protein (hs-CRP) score and IBD. METHODS: This study involved 127 case/non-case pairs matched by age and sex of participants who underwent …
Mirikizumab Efficacy in Ulcerative Colitis: Association With Pretreatment Geboes Score Features in a Case Series
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40665891
No Abstract
Isolated Anastomotic Ulcers Are Associated with a Higher Long-Term Risk for Postoperative Recurrence and a Differential Mucosa-Associated Microbiome Composition in Patients with Crohn's Disease Following Ileocolic Resection
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40665935
BACKGROUND: The clinical relevance and underlying mechanism of isolated anastomotic ulcers (IAUs) following ileocolic resection (ICR) in patients with Crohn's disease (CD) are poorly understood. This study aimed to assess the postoperative recurrence (POR) risk and the mucosa-associated microbiome composition in CD patients with or without IAUs among those with …
Correction: Causal associations of thyroid function with inflammatory bowel disease and the mediating role of cytokines
Publication Year: 2025 Source: Front Endocrinol (Lausanne) PMID: 40666056
[This corrects the article DOI: 10.3389/fendo.2024.1376139.].
Post Hoc Analysis of Anxiety and Behavioral Changes in Japanese Patients With Inflammatory Bowel Disease due to the COVID-19 Pandemic: Relationship Between Municipal Population at the Place of Residence and Anxiety
Publication Year: 2025 Source: JGH Open PMID: 40666190
AIMS: The Japan COVID-19 Survey and the Questionnaire for Inflammatory Bowel Disease (J-DESIRE) identified multiple factors associated with anxiety regarding the novel coronavirus disease 2019 (COVID-19). However, no regional differences in anxiety were observed. In this post hoc analysis of J-DESIRE, we investigated the relationship between the municipal population size …
A Review of the Current State of Off-Label Therapies for Pediatric Inflammatory Bowel Disease
Publication Year: 2025 Source: Pediatr Discov PMID: 40666243
Off-label use of biologic therapies in patients with pediatric inflammatory bowel disease (IBD) has seen an increase in utilization. In this paper, we review the current state of off-label therapies in the pediatric IBD population. Real-world use of ustekinumab (UST), vedolizumab (VDZ), upadacitinib (UPA), tofacitinib, and ozanimod in the adult …
Cell-type-resolved genetic regulatory variation shapes inflammatory bowel disease risk
Publication Year: 2025 Source: medRxiv PMID: 40666361
Most genetic variants associated with complex diseases lie in non-coding regions, complicating efforts to identify effector genes and relevant cell types. Here, we map cis-eQTLs across 2.2 million single cells from blood and intestinal biopsies of 421 individuals, including 125 with inflammatory bowel disease (IBD). Cell-type-level eQTLs were more distal …
Dissecting the Genetic Relationship Between Severe Mental Disorders and Autoimmune Diseases
Publication Year: 2025 Source: medRxiv PMID: 40666362
Severe mental disorders have been linked to immune system dysfunction. While a genetic association between mental disorders and autoimmune diseases has been suggested, their genetic relationship remains incompletely understood. Utilizing a complementary set of statistical analyses, we conducted a comprehensive investigation of the genetic architecture between severe mental disorders (major …
Efficacy and safety of upadacitinib for patients with immune-mediated inflammatory diseases: a systematic review and meta-analysis
Publication Year: 2025 Source: Front Immunol PMID: 40666511
OBJECTIVE: There is a growing array of options for the treatment of immune-mediated inflammatory diseases (IMIDs). To explore upadacitinib's efficacy and safety in autoimmune disease treatment, we conducted this study. METHODS: Pubmed, Web of Science and Embase were searched for randomized controlled trials related to the treatment of upadacitinib from …
Cimifugin ameliorates ulcerative colitis-related lung injury by modulating the JAK1/STAT1 signaling pathway and macrophage M1 polarization
Publication Year: 2025 Source: Front Immunol PMID: 40666519
INTRODUCTION: Ulcerative colitis (UC)-related lung injurys is a commonly overlooked extraintestinal manifestation and there are currently no drugs with definitive efficacy available. Cimifugin has been found to inhibit aberrant inflammation and oxidative stress, but its efficacy in UC-related lung injurys has not yet been demonstrated. METHODS: This study explored the …
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