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Cytomegalovirus Proctitis Mimicking Inflammatory Bowel Disease in an Immunocompetent Elderly Patient: A Diagnostic Challenge
Publication Year: 2025 Source: Cureus PMID: 40666552
Cytomegalovirus (CMV) colitis is an opportunistic virus typically diagnosed in immunocompromised patients. CMV proctitis is rarely reported in immunocompetent hosts. We describe a 71-year-old immunocompetent male who presented with persistent diarrhea and was CMV-negative on initial histopathology staining but was found to have severe CMV proctitis with rectal involvement diagnosed …
Genetically-programmed Hypervesiculation of Lactiplantibacillus plantarum Increases Production of Bacterial Extracellular Vesicles with Therapeutic Efficacy in a Preclinical Inflammatory Bowel Disease Model
Publication Year: 2025 Source: bioRxiv PMID: 40666845
Inflammatory bowel diseases (IBD) affect over 6 million people globally and current treatments achieve only 10-20% rates of durable disease remission. Bacterial extracellular vesicles (BEVs) from probiotic lactic acid bacteria (LAB) are a promising novel therapeutic with mechanisms holding potential to drive increased rates of durable disease remission, including immunomodulation …
A collection of patient-derived intestinal organoid lines reveals epithelial pheno-types associated with genetic drivers of pediatric inflammatory bowel disease
Publication Year: 2025 Source: bioRxiv PMID: 40666956
Pediatric Inflammatory Bowel Disease (IBD) is a chronic condition characterized by per-sistent intestinal inflammation in children and adolescents. Despite a rising global incidence, the underlying causes and optimal management strategies for pediatric IBD are still not fully understood. Compared to adult IBD, pediatric IBD frequently presents with distinct disease phenotypes, …
Exploration of fecal microbiota in newly diagnosed patients with inflammatory bowel disease using shotgun metagenomics
Publication Year: 2025 Source: Front Cell Infect Microbiol PMID: 40667420
INTRODUCTION: Dysbiosis is a key mechanism in inflammatory bowel disease (IBD) pathophysiology. Previous microbiota studies in IBD generally have involved patients treated with immunosuppressive agents, which can affect the results. We aimed to elucidate the fecal microbiota composition in newly diagnosed treatment-naive IBD patients. METHODS: Microbiota from stool samples were …
Cannabis use in Patients With Inflammatory Bowel Disease is Associated With Longer Endoscopic Duration and Endoscopic Inflammation
Publication Year: 2025 Source: Crohns Colitis 360 PMID: 40667460
BACKGROUND: Patients with inflammatory bowel disease (IBD) often experience symptoms refractory to available treatments, prompting the use of alternative therapies like cannabis. Previous studies have shown cannabis users require higher levels of sedation for procedures. The anti-inflammatory effects of cannabis have been studied with mixed conclusions. We aimed to investigate …
Sex Disparities in Treatment Trajectories of Inflammatory Bowel Disease Are Associated With Diagnostic Delay
Publication Year: 2025 Source: Crohns Colitis 360 PMID: 40667461
BACKGROUND: Diagnostic delay (DD) is a common finding in inflammatory bowel diseases (IBD). The reasons and effects of this delay are frequently underestimated, particularly in the context of sex. Our aims were to examine the impact of delayed diagnosis in IBD, with a particular focus on sex disparities. METHODS: We …
Dashboard-Guided Anti-TNF Induction: An Effective Strategy to Minimize Immunogenicity While Avoiding Immunomodulators-A Single-Center Cohort Study
Publication Year: 2025 Source: Crohns Colitis 360 PMID: 40667463
BACKGROUND: Proactive therapeutic drug monitoring facilitates early dose optimization to prevent primary and secondary failure to antitumor necrosis factor (TNF). We aimed to investigate the impact of dashboard-guided induction dosing strategy on anti-TNF durability and immunogenicity. METHODS: We conducted a single-center cohort analysis of patients with Crohn's disease (CD) and …
Efficacy and Safety of Three Janus Kinase Inhibitors in Ulcerative Colitis Patients over and under 65 Years of Age: A Real-World Comparative Analysis
Publication Year: 2025 Source: Inflamm Intest Dis PMID: 40667521
INTRODUCTION: It remains unclear whether Janus kinase (JAK) inhibitors differ in efficacy and safety between elderly and non-elderly patients with ulcerative colitis. METHODS: We retrospectively compared outcomes between patients who started a JAK inhibitor at >/=65 years (elderly group) and those <65 years (non-elderly group). RESULTS: Among 228, 215, and …
Clinical Trial: Association Between Early Disease Clearance and Long-Term Outcomes-4-Year Results From the Phase 3 UNIFI Study of Ustekinumab in Ulcerative Colitis
Publication Year: 2025 Source: Aliment Pharmacol Ther PMID: 40668079
BACKGROUND: Achievement of disease clearance (simultaneous symptomatic remission and histo-endoscopic mucosal improvement [HEMI]) following induction therapy may lead to better long-term outcomes in ulcerative colitis (UC). AIM: To evaluate disease clearance in the phase 3 UNIFI program and its association with long-term outcomes. METHODS: UNIFI comprised randomised, placebo-controlled induction and …
The c.64 + 2 T > A Founder Variant Hits Home: Report on 14 Patients Expands the Phenotypic Landscape of Inherited ARPC1B Deficiency - a Comparative Analysis
Publication Year: 2025 Source: Clin Rev Allergy Immunol PMID: 40668456
BACKGROUND: Inherited ARPC1B deficiency (ARPC1BD) is a rare autosomal recessive inborn error of immunity that manifests with allergic, infective, and autoimmune/inflammatory features. Only about three dozen patients with ARPC1BD have been reported in the literature thus far. METHODS: We describe 14 patients (ten families) with ARPC1BD from Nepal. Many of …
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