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An enhanced bioactive chitosan-modified microemulsion for mucosal healing of ulcerative colitis
Publication Year: 2025 Source: Int J Biol Macromol PMID: 39581424
No Abstract
Mortality risk associated with MASLD, MASLD type and different cardiometabolic risk factors in IBD patients: A long-term prospective cohort study
Publication Year: 2025 Source: Dig Liver Dis PMID: 39581836 DOI: 10.1016/j.dld.2024.11.002
PURPOSE: To examine the mortality risk associated with metabolic dysfunction-associated steatotic liver disease (MASLD), MASLD type, lean/non-lean MASLD and different cardiometabolic risk factors (CMRFs) in patients with inflammatory bowel disease (IBD) based on a long-term prospective cohort. METHODS: Prevalent IBD patients at baseline who were free of alcoholic liver disease, …
Lipid Nanoparticles With Fine-Tuned Composition Show Enhanced Colon Targeting as a Platform for mRNA Therapeutics
Publication Year: 2025 Source: Adv Sci (Weinh) PMID: 39585189
No Abstract
Changes in Editorial Leadership
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 39585862
No Abstract
Probiotic nanovesicles encapsulating baicalin: a strategy to overcome colorectal cancer
Publication Year: 2025 Source: Lett Appl Microbiol PMID: 39586276
Escherichia coli Nissle 1917 (EcN) is a unique probiotic utilized to treat inflammatory bowel disease and irritable bowel syndrome. Outer membrane vesicles (OMVs) from EcN can not only deliver pro-biotic anti-inflammatory molecules to cancer cells to exert anti-rectal cancer effects, but also deliver therapeutic drugs, genes, and other "cargoes" encapsulated …
Gut-homing and intestinal TIGIT(neg)CD38(+) memory T cells acquire an IL-12-induced, ex-Th17 pathogenic phenotype in a subgroup of Crohn's disease patients with a severe disease course
Publication Year: 2025 Source: Mucosal Immunol PMID: 39586377 DOI: 10.1016/j.mucimm.2024.11.008
CD4(+) memory T cell (T(M)) reactivation drives chronicity in inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis. Defects driving loss of T(M) regulation likely differ between patients but remain undefined. In health, approximately 40 % of circulating gut-homing CD38(+)T(M) express co-inhibitory receptor T-cell immunoreceptor with immunoglobulin and …
Burden of inflammatory bowel disease among elderly, 1990-2019: A systematic analysis based on the global burden of disease study 2019
Publication Year: 2025 Source: Autoimmun Rev PMID: 39586389 DOI: 10.1016/j.autrev.2024.103708
AIM: The number of elderly patients with inflammatory bowel disease (IBD) has increased dramatically over the past few decades. Understanding the global burden of IBD in the elderly can provide a valuable basis for formulating future healthcare policies. This study aimed to comprehensively assess the global burden of IBD in …
Iron and Inflammatory Cytokines Synergistically Induce Colonic Epithelial Cell Ferroptosis in Colitis
Publication Year: 2025 Source: J Gastroenterol Hepatol PMID: 39586593 DOI: 10.1111/jgh.16826
Inflammatory bowel disease (IBD) is an inflammatory disease that occurs to the intestinal tract. Many patients with IBD often develop anemia and often receive oral iron supplementation. Many of them develop non-compliance with oral iron therapy, but the mechanisms are not well understood. We interrogated whether colonic epithelial iron overload …
Top-down infliximab plus azathioprine versus azathioprine alone in patients with acute severe ulcerative colitis responsive to intravenous steroids: a parallel, open-label randomised controlled trial, the ACTIVE trial
Publication Year: 2025 Source: Gut PMID: 39586616
BACKGROUND: It is unknown which maintenance therapy is the most effective option for patients admitted for an acute severe ulcerative colitis (ASUC) episode responding to intravenous steroids. METHODS: We conducted a multicentre, parallel-group, open-label randomised controlled trial among 23 French centres in thiopurine and biologics-naive adults admitted for ASUC responding …
Effect of Bacteroides on Crohn's disease
Publication Year: 2025 Source: Z Gastroenterol PMID: 39586813 DOI: 10.1055/a-2435-2659
No Abstract
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