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Trends and Symptoms Among Increasing Proportion of African Americans with Early-Onset Colorectal Cancer over a 60-Year Period
Publication Year: 2025 Source: Dig Dis Sci PMID: 39586927 DOI: 10.1007/s10620-024-08739-5
BACKGROUND: The proportion of early onset colorectal cancer (EOCRC) is alarming in adults, including in African Americans (AA). AIM: To investigate differences between EOCRC compared to late-onset colorectal cancer (LOCRC) among AA patients. METHODS: This retrospective study reviewed demographic, clinical presentations, colonoscopy, and pathology reports of patients at Howard University …
Gut-on-a-Chip Reveals Enhanced Peristalsis Reduces Nanoplastic-Induced Inflammation
Publication Year: 2025 Source: Small PMID: 39587010
No Abstract
In silico integrative scRNA analysis of human colonic epithelium indicates four tuft cell subtypes
Publication Year: 2025 Source: Am J Physiol Gastrointest Liver Physiol PMID: 39589317 DOI: 10.1152/ajpgi.00182.2024
This study integrated and analyzed human single-cell RNA sequencing data from four publicly available datasets to enhance cellular resolution, unveiling a complex landscape of tuft cell heterogeneity within the human colon. Four tuft subtypes (TC1-TC4) emerged, as defined by unique gene expression profiles, indicating potentially novel biological functions. Tuft cell …
Alpha Guy? No, Alpha Gal-Important to Remember in Patients with IBD in Endemic Areas
Publication Year: 2025 Source: Dig Dis Sci PMID: 39589464 DOI: 10.1007/s10620-024-08697-y
No Abstract
Understanding diagnostic delays and health outcomes for inflammatory bowel disease: a mixed-methods study of patients' perspectives
Publication Year: 2025 Source: Qual Life Res PMID: 39589668 DOI: 10.1007/s11136-024-03852-4
PURPOSE: Inflammatory bowel disease (IBD) is a chronic condition affecting the digestive system with symptoms that are often episodic, unpredictable, socially stigmatizing, and impact quality of life. While a timely diagnosis reduces the risk of complications and improves health outcomes, diagnostic delays (DDs) are common. Our study used narratives and …
Brodalumab: Six-Year US Pharmacovigilance Report
Publication Year: 2025 Source: Dermatol Ther (Heidelb) PMID: 39589679
No Abstract
Sarcopenia and immune-mediated inflammatory diseases: Evaluating causality and exploring therapeutic targets for sarcopenia through Mendelian randomization
Publication Year: 2025 Source: Int Immunopharmacol PMID: 39591827 DOI: 10.1016/j.intimp.2024.113687
BACKGROUND: An increasing body of evidence has revealed the association between immune-mediated inflammatory diseases (IMIDs) and sarcopenia. However, a genetically direct causality between IMIDs and sarcopenia remains elusive. METHODS: To investigate the relationship between IMIDs and sarcopenia-related traits and identify potential therapeutic targets, a Mendelian randomization (MR) was performed. We …
Electronic Health Records-based identification of newly diagnosed Crohn's Disease cases
Publication Year: 2025 Source: Artif Intell Med PMID: 39591878
No Abstract
Stressing out the intestinal microbiota via a brain-neuroglandular circuit
Publication Year: 2025 Source: Cell Res PMID: 39592707
No Abstract
Gossypetin Alleviates DSS-induced Colitis by Regulating COX2 and ROS-JNK Signaling
Publication Year: 2025 Source: Curr Pharm Biotechnol PMID: 39601169 DOI: 10.2174/0113892010331882240901095733
BACKGROUND: Inflammatory Bowel Disease (IBD) represents a chronic and recurrent inflammatory condition affecting the gastrointestinal tract, with a rising global incidence. Current treatment approaches include surgery and drugs. However, surgeries are invasive procedures, while drug treatments often present with various side effects. Gossypetin, a flavonoid found abundantly in plants such …
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