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Risk factors and incidence of surgical wound infection after stoma reversal: A systematic review and meta-analysis
Publication Year: 2025 Source: PLoS One PMID: 40668781
To determine the incidence and risk factors of incisional infection following stoma reversal surgery. As of July 30, 2024, an extensive literature search was conducted on databases including PubMed, Web of Science, Cochrane, Embase, and OpenGrey. The certainty of evidence was evaluated using the Grading of Recommendations, Assessment, Development, and …
Endoscopic healing in pediatric IBD perpetuates a persistent signature defined by Th17 cells with molecular and microbial drivers of disease
Publication Year: 2025 Source: Cell Rep Med PMID: 40669446
Endoscopic healing (EH) is the major long-term treatment target for inflammatory bowel diseases (IBDs), mainly achieved by immune-suppressive therapies. However, the chronic and relapsing nature of the disease indicates a lifelong persistence of unknown tissue-associated IBD residues. Based on longitudinally collected gastrointestinal biopsies (n = 217) from pediatric patients with …
Bowel Urgency in Crohn's Disease: Effects of Mirikizumab in a Randomized Controlled Phase 3 Trial
Publication Year: 2025 Source: Clin Gastroenterol Hepatol PMID: 40669578
BACKGROUND AND AIMS: Bowel urgency (BU) is an under-recognized and debilitating symptom of Crohn's disease (CD). Mirikizumab, an interleukin-23p19 inhibitor, is efficacious for BU resolution in ulcerative colitis. We evaluated the efficacy of mirikizumab in achieving early BU response and remission among participants with CD enrolled in the Phase 3 …
Antidepressants and risk of inflammatory bowel disease: A drug-target Mendelian randomization study
Publication Year: 2025 Source: J Affect Disord PMID: 40669713
BACKGROUND: Previous studies have found that antidepressants could reduce the risk of IBD, but the results are controversial. Therefore, a drug-target Mendelian randomization was applied to explore the casual relationship between antidepressants and IBD, aiming to identify new preventive uses for the drugs. METHODS: Target genes corresponding to classic SSRI …
Defining difficult endoscopic bowel dilation in inflammatory bowel disease patients: a call for further consideration
Publication Year: 2025 Source: Gastrointest Endosc PMID: 40670024
No Abstract
Genetic insights into the association between inflammatory bowel disease and Alzheimer's disease
Publication Year: 2025 Source: Genes Immun PMID: 40670704
Myeloid cells, including monocytes, macrophages, and microglia, play major roles in innate and adaptive immune responses. Alzheimer's disease (AD) and inflammatory bowel disease (IBD) susceptibility loci are both enriched for genes expressed in myeloid cells, so we assessed whether these myeloid pathways may be shared. Leveraging genome-wide association study results, …
Palmatine Ameliorates High-Temperature and High-Humidity-Induced Enteritis Via Mitophagy and NLRP3 Inflammasome Degradation
Publication Year: 2025 Source: Endocr Metab Immune Disord Drug Targets PMID: 40671221
BACKGROUND: Previous studies have shown that a High-Temperature- and High-Humidity (HTH) environment leads to mild enteritis, accompanied by impaired mitophagy and activated NLRP3-IL-1beta, as found in Inflammatory Bowel Disease (IBD). Therefore, whether Palmatine (PAL), a candidate for treating IBD, ameliorates HTH-induced enteritis via mitophagy-associated mechanisms was examined. This study aimed …
Affordability issues and the need for a reimbursement process of advanced therapy for inflammatory bowel diseases in India
Publication Year: 2025 Source: Curr Med Res Opin PMID: 40671596
Inflammatory bowel disease (IBD) is an aggressive relapsing condition that can develop at a young age and carries a high lifetime risk of medical expenses. Patients with moderate to severe Crohn's disease or Ulcerative colitis need biologic therapy for induction and maintenance of remission. The cost of treating these has …
Human DNA levels in feces reflect gut inflammation and associate with presence of gut species in IBD patients across the age spectrum
Publication Year: 2025 Source: Res Sq PMID: 40671808
Background Feces are a complex matrix that holds precious information regarding gut processes. Comprehensive fecal DNA sequencing is largely utilized as a non-invasive way to profile the gut microbiome, but is majorly overlooked in other fields. Clinical practice and research on Inflammatory Bowel Diseases (IBD) would greatly benefit from accurate …
Genetically proxied risk and protective factors for pancreatic cancer: a systematic review and meta-analysis of Mendelian randomization studies
Publication Year: 2025 Source: J Gastrointest Oncol PMID: 40672103
BACKGROUND: Despite extensive observational evidence implicating lifestyle habits, metabolic factors, hormone levels, predisposing genetic conditions, medications, and other exposures, causal inference regarding pancreatic ductal adenocarcinoma (PDAC) risk factors remain contentious due to residual confounding. This Mendelian randomization (MR) meta-analysis was employed to address unresolved etiological controversies and systematically investigate causal …
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