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Ameliorative effect of nodakenin in combating TNBS-induced ulcerative colitis by suppressing NFƙB-mediated NLRP3 inflammasome pathway

Publication Year: 2025 Source: Naunyn Schmiedebergs Arch Pharmacol PMID: 39042157

No Abstract

Budesonide Versus Mesalamine in Microscopic Colitis: A Comparative Meta-analysis of Randomized Controlled Trials

Publication Year: 2025 Source: J Clin Gastroenterol PMID: 39042479

BACKGROUND: Microscopic colitis (MC) is an inflammatory bowel disease of autoimmune origin that causes chronic watery diarrhea. Medications, including budesonide, mesalamine, loperamide, cholestyramine, and bismuth subsalicylate, are first-line therapies. Meanwhile, azathioprine, 6-mercaptopurine, and methotrexate are indicated for refractory MC. OBJECTIVE: We aim to assess the efficacy and safety of budesonide …

Exhausted Lag-3+ CD4+ T cells are increased in pediatric Inflammatory Bowel Disease

Publication Year: 2025 Source: Clin Exp Immunol PMID: 39044534 DOI: 10.1093/cei/uxae066

T cells are one of the main drivers of inflammatory bowel diseases (IBD). Infliximab (IFX) is used in the treatment of IBD as an anti-inflammatory drug to induce remission by neutralizing TNFalpha. We determined the individual chemokine/homing receptor and cytokine profile in pediatric IBD patients before and during IFX therapy …

Identification of the M2 Macrophage-associated Gene THBS2 as a Predictive Marker for Inflammatory Cancer Transformation

Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 39045635

Ulcerative colitis (UC)-induced colitis-associated colorectal cancer (CAC) has a worse prognosis than sporadic colorectal cancer. And with the incidence of ulcerative colitis on the rise, it is critical to identify new therapeutic targets in time to stop the progression of inflammation to cancer. Through immunohistochemistry (IHC) and Gene Expression Omnibus …

Preventable Predictive Factors of Post-colonoscopy Colorectal Cancer in Inflammatory Bowel Disease

Publication Year: 2025 Source: J Crohns Colitis PMID: 39046784 DOI: 10.1093/ecco-jcc/jjae115

BACKGROUND AND AIM: Post-colonoscopy colorectal cancer [PCCRC] is a colorectal cancer [CRC] diagnosed after a colonoscopy in which no cancer was detected [index colonoscopy]. Although the overall cumulative rates of PCCRC are low in both the general population and inflammatory bowel disease [IBD] patients, the overall incidence of PCCRC in …

Successful Long-Term Treatment of Collagenous Sprue With Tacrolimus in a 25-Year-Old With Severe Intestinal Failure

Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 39046809

No Abstract

The Prevalence and Characteristics of Inflammatory Bowel Disease-related Ocular Involvement in Children

Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 39046811 DOI: 10.1093/ibd/izae160

BACKGROUND: Ocular manifestations (OMs) in patients with inflammatory bowel disease (IBD) are uncommon, particularly in children. We aimed to explore the prevalence and characteristics of IBD-associated OM in a large cohort study. METHODS: A cross-sectional study was performed using the Maccabi Healthcare Services (MHS) database. The eligible population included all …

Education level and biologic therapy are the related factors of mucosal healing in Patients with Crohn's disease

Publication Year: 2025 Source: Arab J Gastroenterol PMID: 39048387

No Abstract

Family reflections: inflammatory bowel disease and dandelions

Publication Year: 2025 Source: Pediatr Res PMID: 39048667

No Abstract

Invasive Therapeutic Strategies for Stricturing Crohn's Disease in Childhood: A Systematic Review and Meta-Analysis

Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 39049794

BACKGROUND: Crohn's disease (CD) is a chronic inflammatory condition of the gastrointestinal tract. Current drugs are not effective for treating the primary fibrotic component of CD. Recommended invasive treatments include endoscopic balloon dilation, surgery with resection, or strictureplasty. This meta-analysis compared invasive treatment techniques for CD-related strictures in the pediatric …

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