Research Articles Library
Literature Analysis Tools
Advanced Search
Filter by PMID, year, source, DOI and other criteria
Literature Analysis
Analyze research trends and hotspots
Batch Export
Export search results to Excel/PDF
Colitis-primed circulating T cells drive small intestinal barrier function through Nod2, microbiota and myosin light chain kinase-dependent mechanisms
Publication Year: 2025 Source: bioRxiv PMID: 40672311
Inflammatory bowel diseases (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), are characterized by intestinal inflammation and barrier dysfunction. While disruption of the intestinal barrier contributes to the pathogenesis of IBD, yet how colonic inflammation alters small intestinal homeostasis remains poorly defined. Here, we demonstrate that three models of …
Exploring the beneficial effects of GHK-Cu on an experimental model of colitis and the underlying mechanisms
Publication Year: 2025 Source: Front Pharmacol PMID: 40672369
INTRODUCTION: Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) characterized by mucosal damage and impaired epithelial barrier function. While glycyl-l-histidyl-l-lysine-copper (GHK-Cu) exhibits known anti-inflammatory properties, its therapeutic mechanisms in UC remain undefined. This study was designed to systematically evaluate the therapeutic potential of GHK-Cu in a dextran sulfate …
Azathioprine Metabolites in Erythrocytes and DNA for Therapy Monitoring in Very Early Onset Inflammatory Bowel Disease Pediatric Patients
Publication Year: 2025 Source: ACS Pharmacol Transl Sci PMID: 40672687
Azathioprine is used for inflammatory bowel disease (IBD) therapy. Patients under 6 years of age (very early onset, VEO-IBD) showed distinctive clinical characteristics, such as increased activity of thiopurine-methyltransferase (TPMT), a crucial enzyme for thiopurine metabolism. TPMT and PACSIN2 polymorphisms were associated with azathioprine efficacy. This study investigated the role …
Early Identification of Pediatric Inflammatory Bowel Disease Based on a Noninvasive Multivariable Predictive Model
Publication Year: 2025 Source: J Inflamm Res PMID: 40672806
BACKGROUND: Early identification of pediatric inflammatory bowel disease (IBD) improves long-term outcomes; yet, significant diagnostic delays persist. This study aimed to establish and validate the optimal model of noninvasive evaluation tests to help clinicians with the early identification of pediatric IBD. METHODS: The study adopted a retrospective development and prospective …
A core human gut microbe, Mediterraneibacter gnavus, produces a broad-spectrum bacteriocin mediterrocin
Publication Year: 2025 Source: mBio PMID: 40673680
A diverse, stable community of microbes in the human gut is strongly tied to health. The factors that regulate microbial community structure and dynamics are ill-defined. In this study, we discover mediterrocin, a bacteriocin produced by the core member of the human gut microbiota, Mediterraneibacter gnavus (previously Ruminococcus gnavus). Following …
A Droplet Microfluidic-Derived Pathological Microenvironment-Activated Spore Nanozyme Device for the Precise Regulation and Treatment of Colitis
Publication Year: 2025 Source: ACS Nano PMID: 40674013
Abnormal colonic features, such as excessive generated reactive oxygen species (ROS) and increased epithelial oxygenation, result in the overproliferation of harmful aerobic bacteria, which promotes intestinal dysbiosis and exacerbates the progression of colitis. Conventional therapies include the use of drugs to control the inflammatory response or biologic agents (e.g., probiotics) …
Early-Onset Gastrointestinal Cancers: A Review
Publication Year: 2025 Source: JAMA PMID: 40674064
IMPORTANCE: Early-onset gastrointestinal (GI) cancer is typically defined as GI cancer diagnosed in individuals younger than 50 years. The incidence of early-onset GI cancer is rising globally, and early-onset GI cancers represent the most rapidly increasing early-onset cancer in the US. OBSERVATIONS: Worldwide, among early-onset GI cancers reported in 2022, …
Outcomes of medical and surgical treatment for intestinal fistulizing Crohn's disease
Publication Year: 2025 Source: PLoS One PMID: 40674301
BACKGROUND: Intestinal penetrating complications of Crohn's disease (CD) are challenging issues, but it is difficult to decide between medical treatment and surgery. This study aimed to evaluate the outcomes of medical and surgical therapy in patients with non-perianal fistulizing CD. OBJECTIVE: Our study aimed to evaluate and compare the effectiveness …
Inflammatory Bowel Disease or Drug-Induced Colitis? A Diagnostic Challenge in a CML Case Under Dasatinib Therapy
Publication Year: 2025 Source: Turk J Haematol PMID: 40674337
No Abstract
Transmission of maternal oral pathobionts to the infant gut predisposes offspring to exacerbated enteritis
Publication Year: 2025 Source: Cell Rep PMID: 40675146
Infants acquire maternal microbes from various body sites, which become early colonizers of the infant gut. Consequently, disruption of healthy maternal microbiota, particularly maternal gut dysbiosis, can influence the composition of offspring's gut microbiota and affect their health outcomes. However, the effects of non-gut maternal microbes on infant health and …
Need more literature?
The current database contains 98453 research articles. If you need to search for more literature or perform AI analysis, please use our knowledge acquisition module or explore external literature resources.
External Resources: Access comprehensive literature databases worldwide