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Development and external validation of an endoscopic and histologic pouchitis assessment tool: the Atlantic Pouchitis Index
Publication Year: 2025 Source: Clin Gastroenterol Hepatol PMID: 40675404
BACKGROUND & AIMS: No fully validated indices to measure pouchitis activity exist. We aimed to develop and externally validate a novel endoscopic and histologic index. METHODS: Endoscopists and pathologists used 11 (4 endoscopic, 4 histologic, 3 composite) existing indices and items from a prior Research and Development/University of California Los …
Thiopurine shunting in a renal transplant recipient: prepregnancy considerations with azathioprine and allopurinol
Publication Year: 2025 Source: BMJ Case Rep PMID: 40675654
Fertility and reproductive counselling are integral for female kidney transplant recipients. Although classified as high-risk, successful pregnancies in this group are increasingly reported. Immunosuppressive therapy, azathioprine and calcineurin inhibitors, is crucial for preventing graft rejection and safe during pregnancy. However, azathioprine metabolism can vary, leading to the production of metabolites, …
Surveying Dietary Beliefs of Patients With Inflammatory Bowel Disease and Their Treating Clinicians-Have These Changed Over Time?
Publication Year: 2025 Source: J Hum Nutr Diet PMID: 40676893
INTRODUCTION: The role of diet in inflammatory bowel disease (IBD) remains controversial, with limited clinical guidelines available. There is increasing evidence of the potential role of diet as therapy in IBD. We conducted a survey nearly a decade ago assessing the perspectives of patients and clinicians on diet and IBD …
Management of paediatric ulcerative colitis, part 1: Ambulatory care-An updated evidence-based consensus guideline from the European Society of Paediatric Gastroenterology, Hepatology and Nutrition and the European Crohn's and Colitis Organisation
Publication Year: 2025 Source: J Pediatr Gastroenterol Nutr PMID: 40677018
OBJECTIVES: Despite advances in the management of ambulatory paediatric ulcerative colitis (UC), challenges remain as many patients are refractory to therapy and some require colectomy. The aim of these guidelines is to provide an update on optimal care for UC through detailed recommendations and practice points. METHODS: These guidelines are …
Gastroprotective Effects of S-Adenosyl-L-Methionine Through Its Antioxidant and Anti-inflammatory Properties on Dextran Sulfate Sodium-Induced Chronic Colitis in Swiss Albino Mice
Publication Year: 2025 Source: Cureus PMID: 40677439
INTRODUCTION: Ulcerative colitis (UC) is the most common form of inflammatory bowel disease worldwide. It is a chronic, debilitating condition that affects an individual throughout life. Patients of UC tend to have a reduced quality of life from continuous disease activity and significant complications, with a risk of developing colon …
Azathioprine Hypersensitivity Syndrome Mimicking an Infection in a Systemic Lupus Erythematosus Patient: A Case Report
Publication Year: 2025 Source: Cureus PMID: 40677507
Azathioprine (AZA) is used in clinical practice as a steroid-sparing medication to treat diverse systemic autoimmune diseases, such as inflammatory bowel disease, rheumatoid arthritis, and systemic lupus erythematosus. The adverse effects of AZA use include azathioprine hypersensitivity syndrome (AHS). AHS is a rare entity, but it can lead to fatal …
Diagnostic yield of video capsule endoscopy vs simple balloon enteroscopy in small intestinal disorders: A systematic review
Publication Year: 2025 Source: World J Gastrointest Endosc PMID: 40677578
BACKGROUND: Small-bowel disorders, including obscure gastrointestinal bleeding (OGIB), Crohn's disease, and tumors, require accurate diagnostic approaches for effective treatment. Video capsule endoscopy (VCE) and simple balloon enteroscopy (SBE) are widely used; however, each modality has limitations, particularly regarding therapeutic intervention and diagnostic yield. AIM: To evaluate diagnostic yields of various …
A retrospective study on the demographics and epidemiology of pyoderma gangrenosum: Insights from a single-center analysis
Publication Year: 2025 Source: JAAD Int PMID: 40677729
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Gpr37 modulates the severity of inflammation-induced GI dysmotility by regulating enteric reactive gliosis
Publication Year: 2025 Source: iScience PMID: 40678517
The enteric nervous system (ENS) is contained within two layers of the gut wall and is made up of neurons and enteric glial cells (EGCs) that regulate gastrointestinal (GI) function. EGCs in both inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) change in response to inflammation, referred to as …
Dietary fermentable polyols fuel gut inflammation through M1 macrophage polarization and gut microbiota
Publication Year: 2025 Source: iScience PMID: 40678521
While fermentable oligo- and di-, mono-saccharides and polyols (FODMAPs) have been implicated in exacerbating inflammatory bowel disease (IBD) symptoms, the exact influence of FODMAPs on gut microbiota and inflammation is unclear. Here, we show that sorbitol, a polyol, exacerbates colitis in mice induced by dextran sodium sulfate (DSS). Sorbitol increases …
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