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The impact of biological interventions on health-related quality of life in adults with Crohn's disease: a systematic review with meta-analysis
Publication Year: 2025 Source: EClinicalMedicine PMID: 40678697
BACKGROUND: Health-related quality of life (HRQoL) is one of the main issues in Crohn's disease (CD). We systematically assessed the effects of a biological treatment on HRQoL in adults with CD. METHODS: We searched MEDLINE, EMBASE, and CENTRAL from inception to 26 Jul 2024 for randomised controlled trials (RCTs) investigating …
Kushenol I combats ulcerative colitis via intestinal barrier preservation and gut microbiota optimization
Publication Year: 2025 Source: World J Gastroenterol PMID: 40678703
BACKGROUND: Kushenol I (KSCI) exhibits potential anti-inflammatory and antioxidant activities. However, its therapeutic effects and mechanisms in ulcerative colitis (UC) remain unclear. AIM: To investigate the therapeutic effects and mechanisms of KSCI in alleviating UC. METHODS: Therapeutic targets for KSCI in treating UC were identified using network pharmacology. Molecular docking …
Evaluating luminal and post-operative Crohn's disease activity on magnetic resonance enterography: A review of radiological disease activity scores
Publication Year: 2025 Source: World J Gastroenterol PMID: 40678704
Magnetic resonance enterography (MRE) is a non-invasive, radiation-free imaging modality that facilitates the assessment of transmural Crohn's disease activity. It offers advantages over ileo-colonoscopy, which is limited to mucosal-level evaluation, cannot routinely assess small bowel segments proximal to the terminal ileum, and is unable to detect extra-luminal complications. Despite these …
Ulcerative colitis: Timeline to a cure
Publication Year: 2025 Source: World J Gastroenterol PMID: 40678706
Ulcerative colitis has baffled researchers since the early 20(th) century. The prevailing explanation attributes the chronic recurring episodes of bloody diarrhea and abdominal pain to some form of immune abnormality, despite the lack of supporting evidence. This highlights the critical need for innovative research directions and methodologies to uncover the …
The Emerging Role of CCL17 in the Immunologic Regulation of Inflammatory Bowel Disease
Publication Year: 2025 Source: J Gastroenterol Hepatol PMID: 40678822
Chemokine (C-C) ligand 17 (CCL17) is a key molecule that mediates immune cell migration and inflammation. As a ligand for the type 4 C-C chemokine receptor (CCR4), CCL17 mainly affects T cells, but also influences other cell types, suggesting a broader role in immune regulation. This review comprehensively demonstrates the …
Editorial on 'Prevalence and Predictors of Symptoms of Anxiety or Depression at Diagnosis in Patients With Inflammatory Bowel Disease: An Inception Cohort'
Publication Year: 2025 Source: Aliment Pharmacol Ther PMID: 40678901
No Abstract
Editorial on 'Prevalence and Predictors of Symptoms of Anxiety or Depression at Diagnosis in Patients With Inflammatory Bowel Disease: An Inception Cohort'. Authors' Reply
Publication Year: 2025 Source: Aliment Pharmacol Ther PMID: 40678902
No Abstract
[Severe primary cytomegalovirus infection in an immunocompromised patient: a case report]
Publication Year: 2025 Source: Klin Mikrobiol Infekc Lek PMID: 40678961
A 35-year-old woman with Crohn s disease who was receiving long-term immunosuppressive therapy with azathioprine developed a primary cytomegalovirus (CMV) infection, likely transmitted by her son after he started attending kindergarten. The infection took a severe course, characterized by a high viral load, sepsis, and subsequent CMV pneumonitis requiring mechanical …
Attenuation of colitis-related metabolic dysregulation via consumption of wholemeal sourdough bread but not wholemeal bread: a molecular discovery
Publication Year: 2025 Source: Food Funct PMID: 40679055
Epidemiological studies reveal that the majority of adult patients with inflammatory bowel disease (IBD) are obese and/or overweight. Whole wheat sourdough produced by lactic acid bacterial (LAB) fermentation can provide numerous benefits. In this study, the potential therapeutic effects of consuming whole wheat sourdough bread (singly fermented by two high-metabolite-producing …
Deciphering the microbiome-metabolome landscape of an inflammatory bowel disease inception cohort
Publication Year: 2025 Source: Gut Microbes PMID: 40679059
The gut microbiota contribute to the etiopathogenesis of inflammatory bowel disease (IBD), but limitations of prior studies include the use of sequencing alone (restricting exploration of the contribution of microbiota functionality) and the recruitment of patients with well-established disease (introducing potential confounders, such as immunomodulatory medication). Here, we analyze a …
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