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Evaluation of remission in ulcerative colitis: Relationship between clinical, endoscopic, and histological markers as predictors of relapse
Publication Year: 2025 Source: Gastroenterol Hepatol PMID: 40147713 DOI: 10.1016/j.gastrohep.2025.502437
INTRODUCTION: In ulcerative colitis (UC), STRIDE-II consensus has established the long-term goal of achieving endoscopic remission (ER), which helps reduce inflammatory burden, prevent permanent intestinal damage, and improve patient's quality of life. However, achieving histological remission (HR) is also associated with a lower risk of experiencing outbreaks of inflammatory activity, …
The Burden of Extra-Articular Manifestations in Axial Spondyloarthritis: A Moroccan Single-Centre Study
Publication Year: 2025 Source: Musculoskeletal Care PMID: 40148226 DOI: 10.1002/msc.70087
INTRODUCTION: Axial spondyloarthritis (axSpA) is a chronic inflammatory disease with heterogeneous clinical manifestations, including extra-articular manifestations (EAMs) such as acute anterior uveitis (AAU), inflammatory bowel disease (IBD), and psoriasis. This study aimed to assess the impact of EAMs on disease characteristics in axSpA patients. MATERIALS AND METHODS: A cross-sectional study …
EMIBD9: Estimating 9 condensed IBD coefficients, inbreeding and relatedness from marker genotypes
Publication Year: 2025 Source: Heredity (Edinb) PMID: 40148499 DOI: 10.1038/s41437-024-00739-5
No Abstract
Recurrent Abdominal Pain in a Child - Evaluation and Management
Publication Year: 2025 Source: Indian J Pediatr PMID: 40148656 DOI: 10.1007/s12098-025-05469-y
Recurrent abdominal pain (RAP) is defined as the presence of at least 3 episodes of abdominal pain for 3 mo duration, including both organic and functional etiology. Up to 95% of the causes of RAP are due to functional abdominal pain disorders (FAPD). Peptic ulcer disease, cholelithiasis, chronic pancreatitis, abdominal …
Exploration of Conventional and FDM-Mediated 3D Printed Tablets Fabricated Using HME-Based Filaments for pH-Dependent Drug Delivery
Publication Year: 2025 Source: AAPS PharmSciTech PMID: 40148671
Hot melt extrusion (HME) helps to improve the solubility of BCS class II and IV molecules. The downstream processing of the resulting filaments was crucial in developing the final dosage form. The present work investigates advantages of combining HME with fused deposition modelling (FDM) 3-Dimensional (3D) printing in delivering the …
CTLA4 Alteration and Neurologic Manifestations: A New Family with Large Phenotypic Variability and Literature Review
Publication Year: 2025 Source: Genes (Basel) PMID: 40149457
Cytotoxic-T-lymphocyte-antigen-4 (CTLA-4), a member of the immunoglobulin superfamily, is an essential negative regulator of immune responses that is constitutively expressed on both regulatory (Treg) and activated T cells. To date, heterozygous germline variants in CTLA4, leading to haploinsufficiency, have been associated with several immunological disorders, including hypogammaglobulinemia, multi-organ autoimmunity, lymphoproliferative …
Common Regulatory Mechanisms Mediated by Cuproptosis Genes in Inflammatory Bowel Disease and Major Depressive Disorder
Publication Year: 2025 Source: Genes (Basel) PMID: 40149491 DOI: 10.3390/genes16030339
BACKGROUND: The prevalence of major depressive disorder (MDD) among patients with inflammatory bowel disease (IBD) is significantly higher compared to the general population, suggesting a potential link between their pathogeneses. Cuproptosis, defined as cell death caused by intracellular copper accumulation, has not been thoroughly investigated in the context of IBD …
Disease Acceptance and Control from the Subjective Health Experience Model as Health Perception Predictors in Immune-Mediated Inflammatory Diseases
Publication Year: 2025 Source: Biomedicines PMID: 40149516 DOI: 10.3390/biomedicines13030538
Background/Objectives: The multifactorial nature of immune-mediated inflammatory diseases (IMIDs) requires integrating pathophysiological understanding with subjective patient experiences. Patient-reported outcome measures (PROMs) are a useful tool for incorporating this in routine clinical practice. However, current PROMs do not fully encompass the complete subjective health experiences (SHE) of patients and are thus …
Risk Factors and Awareness of Bone Fragility in Inflammatory Bowel Disease in Taiwan: A Cross-Sectional Study
Publication Year: 2025 Source: Biomedicines PMID: 40149614 DOI: 10.3390/biomedicines13030638
Background/Objectives: Patients with inflammatory bowel disease (IBD) are at a higher risk of developing bone disorders. Awareness and understanding of the disease are crucial for prevention and early diagnosis. Currently, there is no research on the risk factors and knowledge of bone fragility in the population with IBD in Taiwan. …
Genetic Polymorphisms on TNFA, TNFRSF1A, and TNFRSF1B Genes Predict the Effectiveness of Anti-TNF-α Treatment in Inflammatory Bowel Disease Patients
Publication Year: 2025 Source: Biomedicines PMID: 40149645 DOI: 10.3390/biomedicines13030669
Background/Objectives: Tumor necrosis factor alpha (TNF-alpha) is the key inflammatory cytokine involved in the pathogenesis of inflammatory bowel diseases (IBDs). Anti-TNF-alpha therapy has been successfully used for IBD treatment, although the therapeutic response differs among patients due to the genetic background. The aim of this study was to investigate whether …
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