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Comparative Efficacy of Subcutaneous Versus Intravenous Interleukin 12/23 Inhibitors for the Remission of Moderate to Severe Crohn's Disease: A Systematic Review and Meta-Analysis
Publication Year: 2025 Source: Biomedicines PMID: 40149677
Background/Objectives: Interleukin 12/23 inhibitors are a newer class of monoclonal antibodies used to induce and maintain remission for Crohn's disease (CD), a chronic inflammatory bowel disease, when patients do not respond to conventional immunomodulatory drugs or first-line monoclonal antibody therapies. Although biologics are best administered intravenously, subcutaneous administration has been …
Gut Microbiota in Different Treatment Response Types of Crohn's Disease Patients Treated with Biologics over a Long Disease Course
Publication Year: 2025 Source: Biomedicines PMID: 40149684 DOI: 10.3390/biomedicines13030708
Background and Aims: Crohn's disease (CD) is a chronic inflammatory bowel disease (IBD) with a globally increasing prevalence, partially driven by alterations in gut microbiota. Although biological therapy is the first-line treatment for CD, a significant proportion of patients experience a primary non-response or secondary loss of response over time. …
Gut Microbial Targets in Inflammatory Bowel Disease: Current Position and Future Developments
Publication Year: 2025 Source: Biomedicines PMID: 40149692 DOI: 10.3390/biomedicines13030716
Inflammatory bowel disease (IBD) is a debilitating condition in which surgery is often seen as a last resort. However, this is associated with morbidity and, in some cases, mortality. There are emerging therapies that seek to better modulate the immune response of hosts with IBD. Aims: The main aim of …
Absolute Quantitative Metagenomic Analysis Provides More Accurate Insights for the Anti-Colitis Effect of Berberine via Modulation of Gut Microbiota
Publication Year: 2025 Source: Biomolecules PMID: 40149936
Current gut microbiota studies often rely on relative quantitative sequencing. However, under certain circumstances, while the relative quantitative abundance of these bacteria may remain stable, the absolute quantities of specific bacteria can vary considerably. Since the function of bacteria is directly linked to their total numbers, absolute quantification is crucial. …
Diagnostic and Clinical Impact of Double-Balloon Enteroscopy in Small-Bowel Inflammatory Lesions: A Retrospective Cohort Study in a Turkish Population
Publication Year: 2025 Source: Diagnostics (Basel) PMID: 40150004
Background/Objectives: Small-bowel inflammatory lesions are challenging to diagnose thanks to their anatomical complexity and the limitations of conventional imaging. Double-balloon enteroscopy (DBE) allows for direct visualization, biopsy, and therapeutic intervention. This study evaluated the diagnostic yield and clinical impact of DBE in small-bowel inflammatory lesions, particularly in differentiating Crohn's disease …
Xiahuo Pingwei San attenuated intestinal inflammation in dextran sulfate sodium-induced ulcerative colitis mice through inhibiting the receptor for advanced glycation end-products signaling pathway
Publication Year: 2025 Source: J Tradit Chin Med PMID: 40151118
OBJECTIVE: To evaluate the therapeutic effects of Xiahuo Pingwei San (, XHPWS) on ulcerative colitis (UC) in mice and to explore the underlying mechanisms through a network pharmacology approach. METHODS: Ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS) was utilized to identify the chemical composition and authenticate the …
Regulation of mild moxibustion on non-neuronal cholinergic system in ulcerative colitis rats
Publication Year: 2025 Source: J Tradit Chin Med PMID: 40151123
OBJECTIVE: To investigate the effect and mechanism of mild moxibustion on the non-neuronal cholinergic system (NNCS) in rats with ulcerative colitis (UC). METHODS: UC rat model was established by administering 4% dextran sulfate sodium. After 7 d, mild moxibustion, alpha7 nicotinic acetylcholine receptors (alpha7nAchRs) antagonist (alpha-bungarotoxin, alpha-BGT), vesicular acetylcholine transport …
Metabolic mediators of the causal relationship between inflammatory bowel disease and allergic rhinitis: insights from Mendelian randomization
Publication Year: 2025 Source: J Clin Biochem Nutr PMID: 40151399
No Abstract
Recursive Clustering of Cellular Diversity in scRNA-Seq Data
Publication Year: 2025 Source: J Comput Biol PMID: 40151847
In scRNA-seq analysis, cell clusters are typically defined by a single round of feature extraction and clustering. This approach may miss phenotypic differences in cell types that are characterized by genes not sufficiently represented in the feature set derived using all cells, such as rare cell types. This work explores …
Real-world effectiveness of ustekinumab versus anti-TNF or vedolizumab in ulcerative colitis: induction and 12-month maintenance results from the prospective, observational RUN-UC study
Publication Year: 2025 Source: J Crohns Colitis PMID: 40152278 DOI: 10.1093/ecco-jcc/jjaf052
BACKGROUND: Real-world evidence studies of ustekinumab (UST) in ulcerative colitis (UC) are needed because randomized controlled trials do not represent unselected patient populations in everyday clinical practice. Patients with UC were recruited when starting biologic therapy for the first time or switching to a new biologic therapy. This study assessed …
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