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Liver Involvement in Celiac Disease and Immune-Mediated Diseases of the Small Bowel
Publication Year: 2025 Source: Liver Int PMID: 40679061
Disorders of the hepatobiliary system are commonly associated with gastrointestinal (GI) diseases. The GI and hepatobiliary systems interact through the portal vein system and enterohepatic circulation, creating a gut-liver axis that allows for a complex multidirectional interplay between immune, hormonal, dietary and environmental luminal factors that include the gut microbiota. …
Clinical outcome assessment may be a more useful tool for supporting inflammatory bowel disease clinical practice than just patient-reported outcome measures
Publication Year: 2025 Source: Curr Med Res Opin PMID: 40679274
Patients with Inflammatory Bowel Disease approach their treating specialists with a multitude of symptoms. The responses from patient-reported outcome measures (PROM) are challenging to assess and generalize. Most patients who have active disease are happy to discuss their health concerns and get them resolved. Some are wary of the consequences, …
Recurrent Bilateral Asynchronic Neuroretinitis as an Early Ocular Manifestation of Ulcerative Colitis
Publication Year: 2025 Source: Ocul Immunol Inflamm PMID: 40679339
PURPOSE: This report describes a rare and early extraintestinal manifestation of ulcerative colitis (UC), presenting as recurrent, bilateral, sequential neuroretinitis (NR). To our knowledge, this is the first documented case of UC-associated NR successfully treated with a combination of cyclophosphamide and adalimumab. METHODS: Retrospectively, multimodal imaging and medical history were …
Intestinal Epithelial-Derived USP13 Alleviates Colonic Inflammation by Suppressing GRP78-mediated Endoplasmic Reticulum Stress
Publication Year: 2025 Source: Adv Sci (Weinh) PMID: 40679368
Inflammatory bowel disease (IBD) is a chronic condition in which endoplasmic reticulum (ER) stress and subsequent apoptosis of intestinal epithelial cells play significant roles. E3 ubiquitin ligases and deubiquitinases are crucial in IBD pathophysiology by modulating protein ubiquitination. This study investigated the regulatory role of a deubiquitinase ubiquitin-specific peptidase 13 …
Correction: Cerebral Crohn's Disease-Not Your Typical Brain-Gut Connection
Publication Year: 2025 Source: Dig Dis Sci PMID: 40679661
No Abstract
From Homeostasis To Inflammation To Autoimmunity: The Potential Impact of CRP
Publication Year: 2025 Source: Inflammation PMID: 40679780
C-reactive protein (CRP) is a highly conserved pentraxin, synthesized primarily in the liver, and is widely recognized as a highly sensitive biomarker for inflammation and tissue damage. While considerable research has focused on elucidating the structural and functional aspects of CRP, along with its utility as a biomarker reflecting disease …
OTUD3 prevents ulcerative colitis by inhibiting microbiota-mediated STING activation
Publication Year: 2025 Source: Sci Immunol PMID: 40680146
Ulcerative colitis (UC) develops through a complicated interaction between the host and microbiota. Intestinal fibroblasts are believed to play crucial roles in the pathogenesis of UC, but the influence of the host-microbiota interaction on the pathophysiology of intestinal fibroblasts remains poorly understood. Here, we demonstrate that OTU deubiquitinase 3 (OTUD3) …
Spatiotemporal analysis of Crohn's disease reveals PECAM2 signaling at the basis of inflammation-to-fibrosis transition
Publication Year: 2025 Source: J Crohns Colitis PMID: 40680170
BACKGROUND AND AIMS: Crohn's disease is a chronic inflammatory disease of the bowel, often complicated by fibrotic strictures, for which medical treatment is lacking, and surgery is commonly required. The mechanisms underlying the progression from chronic inflammation to fibrosis are not yet defined. We aim to unravel Crohn's disease pathogenesis …
Epidemiology and Healthcare Resource Utilization in Inflammatory Bowel Disease in Colombia between 2017-2021: A Retrospective Claims Database Study
Publication Year: 2025 Source: Gastroenterol Hepatol PMID: 40680925
BACKGROUND AND AIMS: The incidence and prevalence of inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), are increasing across Latinamerica. IBD has an important impact on patients' quality of life and is associated with significant healthcare resource utilization (HCRU). This study aimed to describe the more …
Practical Considerations for the Treatment of Patients with Psoriatic Arthritis and Comorbid Inflammatory Bowel Disease
Publication Year: 2025 Source: Rheum Dis Clin North Am PMID: 40681286
Inflammatory bowel disease is a common comorbidity in patients with psoriasis and psoriatic arthritis. Several key considerations are needed to provide optimal treatment of this unique patient population.
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