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Neutralizing Antibody Response to SARS-CoV-2 Variants After Two mRNA COVID-19 Vaccine Doses in a Cohort of Patients with Inflammatory Bowel Disease from a Southern Italy Tertiary Hospital
Publication Year: 2025 Source: Healthcare (Basel) PMID: 40077070 DOI: 10.3390/healthcare13050508
Introduction: Inflammatory bowel diseases (IBDs) require immunosuppressive drugs like biologics. All IBD patients, including those on biological therapy, should be vaccinated against COVID-19, according to the ECCO recommendations. IBD patients on anti-TNF treatment exhibited lower COVID-19 vaccine responses; however, SARS-CoV-2 variant neutralizing antibody titers have been seldom studied. Methods: IBD …
Association of Hormone Replacement Therapy with Inflammatory Bowel Disease Risk in Women with Menopausal Disorders: A Population-Based Retrospective Cohort Study
Publication Year: 2025 Source: Healthcare (Basel) PMID: 40077140 DOI: 10.3390/healthcare13050578
Background: The long-term effects of hormone replacement therapy (HRT) on inflammatory bowel disease (IBD) remain unclear, necessitating further investigations of the association between HRT and the development of ulcerative colitis and Crohn's disease in postmenopausal women. Methods: This retrospective cohort study utilized Taiwan's National Health Insurance claims (2001-2018) to identify …
Microencapsulation and Probiotic Characterization of Lactiplantibacillus plantarum LM-20: Therapeutic Application in a Murine Model of Ulcerative Colitis
Publication Year: 2025 Source: Nutrients PMID: 40077619
BACKGROUND: Microencapsulation improves the storage, handling, and administration of probiotics by protecting them from environmental factors and adverse conditions in the gastrointestinal tract. This process facilitates their controlled delivery in the body, which can simplify their use in therapies without compromising their therapeutic efficacy. OBJECTIVES: This study investigates the microencapsulation …
Camel Milk Protein Ameliorates Ulcerative Colitis by Modulating Gut Microbiota and Amino Acid Metabolism
Publication Year: 2025 Source: Nutrients PMID: 40077650
The protective effects of the milk fat globule membrane (MFGM) in alleviating inflammation have been reported. However, limited attention has been paid to the key fraction of milk fat globule membrane protein (MFGMP). This study investigated the protective effects of camel MFGMP against dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) …
Addressing Nutritional Knowledge Gaps in Inflammatory Bowel Disease: A Scoping Review
Publication Year: 2025 Source: Nutrients PMID: 40077704 DOI: 10.3390/nu17050833
This scoping review aims to map the existing literature on nutritional knowledge among people with IBD, identify gaps in current understanding, and provide guidance for future educational interventions. Background: Inflammatory bowel diseases (IBDs) are chronic conditions affecting the gastrointestinal tract, where nutrition plays a crucial role in symptom management. Despite …
Thymol Alleviates Colitis by Modulating Intestinal Barrier Damage, Gut Microbiota, and Amino Acid Metabolic Pathways
Publication Year: 2025 Source: J Agric Food Chem PMID: 40077957 DOI: 10.1021/acs.jafc.4c10406
Thymol (THY) is a phenolic monoterpene compound that has garnered attention due to its various biological properties, including antioxidant, anti-inflammatory, and immune-regulatory effects. The purpose of this study was to determine the therapeutic and protective effects of THY in colitic mice, with a particular focus on the mechanisms involving gut …
Novel outcomes in inflammatory bowel disease
Publication Year: 2025 Source: J Crohns Colitis PMID: 40078047 DOI: 10.1093/ecco-jcc/jjaf040
Inflammatory bowel diseases (IBD), Crohn's disease (CD), and ulcerative colitis (UC) are lifelong chronic, relapsing, and remitting conditions that culminate in disease progression in many patients. Effective management of CD and UC requires consideration of both short- and long-term treatment outcomes. Historically, short-term outcomes such as clinical and endoscopic remission …
Myositis of pterygoid muscles and superior ophthalmic vein and cavernous sinus thrombosis in active Crohn's disease undergoing ustekinumab treatment: a case report and literature review
Publication Year: 2025 Source: Front Pharmacol PMID: 40078289 DOI: 10.3389/fphar.2025.1544466
INTRODUCTION: Myositis is a rare extra-intestinal presentation in patients with inflammatory bowel diseases (IBD), and its occurrence has only been described in a few case reports. However, it is essential to consider other potential causes as patients with IBD are more susceptible to infections due to their immunocompromised status, which …
Patient experiences with and adherence to Crohn's disease exclusion diet in Dutch Crohn's disease patients: a cohort study
Publication Year: 2025 Source: Therap Adv Gastroenterol PMID: 40078328 DOI: 10.1177/17562848251323553
BACKGROUND: Dietary therapy is commonly used as a treatment for Crohn's disease (CD). High dietary adherence is associated with achieving clinical remission. Crohn's disease exclusion diet (CDED) is a relatively new therapy in the management of CD. OBJECTIVE: This publication aims to assess the first real-life patient experience with and …
Gut microbiota therapy in gastrointestinal diseases
Publication Year: 2025 Source: Front Cell Dev Biol PMID: 40078367 DOI: 10.3389/fcell.2025.1514636
The human gut microbiota, consisting of trillions of microorganisms, plays a crucial role in gastrointestinal (GI) health and disease. Dysbiosis, an imbalance in microbial composition, has been linked to a range of GI disorders, including inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), celiac disease, and colorectal cancer. These conditions …
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