Research Articles Library
Literature Analysis Tools
Advanced Search
Filter by PMID, year, source, DOI and other criteria
Literature Analysis
Analyze research trends and hotspots
Batch Export
Export search results to Excel/PDF
Examining the Accuracy and Reproducibility of Responses to Nutrition Questions Related to Inflammatory Bowel Disease by Generative Pre-trained Transformer-4
Publication Year: 2025 Source: Crohns Colitis 360 PMID: 40078587 DOI: 10.1093/crocol/otae077
BACKGROUND: Generative pre-trained transformer-4 (GPT-4) is a large language model (LLM) trained on a vast corpus of data, including the medical literature. Nutrition plays an important role in managing inflammatory bowel disease (IBD), with an unmet need for nutrition-related patient education resources. This study examines the accuracy, comprehensiveness, and reproducibility …
Tissue-Specific Metabolic Reprogramming in Innate Lymphoid Cells and Its Impact on Disease
Publication Year: 2025 Source: Immune Netw PMID: 40078781
Recent advances have highlighted the crucial role of metabolic reprogramming in shaping the functions of innate lymphoid cells (ILCs), which are vital for tissue immunity and homeostasis. As tissue-resident cells, ILCs dynamically respond to local environmental cues, with tissue-derived metabolites such as short-chain fatty acids and amino acids directly modulating …
Natural products for the treatment of ulcerative colitis: focus on the JAK/STAT pathway
Publication Year: 2025 Source: Front Immunol PMID: 40078988
Ulcerative colitis (UC) is an autoimmune disease with an incompletely understood pathogenesis. The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathway plays a key role in immune response and inflammation. More and more studies demonstrated that JAK/STAT signaling pathway is associated with the pathogenesis of UC. The …
Artesunate alleviated murine ulcerative colitis by regulating immune response through inhibiting endoplasmic reticulum stress
Publication Year: 2025 Source: Front Immunol PMID: 40079012
Innate and adaptive immunity are intricately linked to the pathogenesis of ulcerative colitis (UC), with dysregulation of the Treg/Th17 balance and M2/M1 macrophage polarization identified as critical factors. Artesunate (ARS) has previously been shown to alleviate UC by inhibiting endoplasmic reticulum stress (ERS). To further investigate the regulatory effects of …
[Intestinal fibrosis in Crohn's disease : towards new therapeutic options?]
Publication Year: 2025 Source: Rev Med Liege PMID: 40079288
Crohn's disease is a chronic inflammatory bowel disease that can lead to fibrostenotic complications. These strictures result from an imbalance between inflammation and excessive healing, leading to an abnormal accumulation of extracellular matrix and a progressive thickening of the intestinal wall. To date, no specific treatment is available to prevent …
SOD mimics delivered to the gut using lactic acid bacteria mitigate the colitis symptoms in a mouse model of inflammatory bowel diseases
Publication Year: 2025 Source: Free Radic Res PMID: 40079422 DOI: 10.1080/10715762.2025.2478121
Inflammatory bowel diseases (IBD), which include Crohn's disease and ulcerative colitis, represent a global health issue as a prevalence of 1% is expected in the western world by the end of this decade. These diseases are associated with a high oxidative stress that induces inflammatory pathways and severely damages gut …
Fecal Incontinence in Adults: New Therapies
Publication Year: 2025 Source: Am J Gastroenterol PMID: 40079456
Fecal incontinence (FI) is the involuntary and recurrent loss of stool. FI significantly affects both physical and social well-being, while imposing a substantial economic burden. The global prevalence of FI is approximately 8%. Risk factors include advanced age, diarrhea, anal sphincter damage from obstetric trauma or anorectal surgery, pelvic floor …
Mirikizumab Improves Quality of Life and Work Productivity in Patients with Moderately to Severely Active Crohn's Disease: Results from the Phase 3 VIVID-1 Study
Publication Year: 2025 Source: Am J Gastroenterol PMID: 40079470
INTRODUCTION: Mirikizumab demonstrated significant efficacy compared with placebo in patients with Crohn's disease (CD) in the phase 3 VIVID-1 study. In this study, we report the impact of mirikizumab vs placebo on health-related quality of life (HRQoL) and work productivity in VIVID-1. METHODS: VIVID-1 patients randomized to receive mirikizumab (N …
Microscopic Colitis and Risk of Venous Thromboembolism: A Nationwide Matched Cohort Study
Publication Year: 2025 Source: Am J Gastroenterol PMID: 40079472
INTRODUCTION: Inflammatory diseases have been associated with increased risk of venous thromboembolism (VTE). However, data on VTE are lacking in large population-based cohorts of microscopic colitis (MC). METHODS: This study included all Swedish adults with incident MC without prior VTE (1990-2017; n = 12,489; follow-up until 2021). MC and subtypes …
Tas2r105 ameliorates gut inflammation, possibly through influencing the gut microbiota and metabolites
Publication Year: 2025 Source: mSystems PMID: 40079578 DOI: 10.1128/msystems.01556-24
Inflammatory bowel disease (IBD) is an immune-mediated gastrointestinal disorder that significantly impacts the life quality of people worldwide. Genetic factors play crucial roles in the development of IBD. Tas2rs, members of the G protein-coupled receptor (GPCR) superfamily, are known for their roles in bitter taste perception. However, Tas2rs have also …
Need more literature?
The current database contains 98453 research articles. If you need to search for more literature or perform AI analysis, please use our knowledge acquisition module or explore external literature resources.
External Resources: Access comprehensive literature databases worldwide