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Role of S-palmitoylation in digestive system diseases
Publication Year: 2025 Source: Cell Death Discov PMID: 40681504
Digestive system diseases, including liver diseases, gastrointestinal cancers, and inflammatory bowel diseases, pose major health challenges worldwide. These conditions are influenced by a range of key metabolic signaling pathways, many of which are regulated by palmitoylation. Palmitoylation is a type of lipid modification catalyzed by DHHC palmitoyl S-acyltransferases (DHHC-PTAs) and …
Modulation of cytokine expression by E. coli Nissle 1917 and its OMV in intestinal epithelial cell line HT-29
Publication Year: 2025 Source: Immunobiology PMID: 40555074 DOI: 10.1016/j.imbio.2025.153092
Inflammatory bowel disease (IBD) is a chronic disease recognized as an autoimmune disorder. The purpose of this is to determine the impact of the E. coli strain Nissle 1917 (EcN) and its outer membrane vesicles (OMVs) on cytokine gene expression in an IBD cell line model (HT29) in the hope …
Multi-enzyme cascade Fe/Mo bimetallic nanozyme with mucosal repair function and immunomodulatory capacity for targeted therapy of ulcerative colitis
Publication Year: 2025 Source: Int J Biol Macromol PMID: 40555315
In this study, FeMoO(4)/MoO(3) nanoparticles (Fe/Mo NPs) were coated with mannose-modified chitosan (CM) to form Fe/Mo@CM nanozyme. Fe/Mo@CM exhibited strong self-cascading multiple antioxidant enzyme-mimicking activities. It simulated the natural antioxidant defense system composed of superoxide dismutase (SOD), glutathione peroxidase (GPx) and peroxidase (POD), catalyzing the decomposition of superoxide anions (O(2)(-)) …
Machine Learning Models Based on CT Enterography for Differentiating Between Ulcerative Colitis and Colonic Crohn's Disease Using Intestinal Wall, Mesenteric Fat, and Visceral Fat Features
Publication Year: 2025 Source: Acad Radiol PMID: 40555639 DOI: 10.1016/j.acra.2025.06.005
PURPOSE: This study aimed to develop radiomic-based machine learning models using computed tomography enterography (CTE) features derived from the intestinal wall, mesenteric fat, and visceral fat to differentiate between ulcerative colitis (UC) and colonic Crohn's disease (CD). METHODS: Clinical and imaging data from 116 patients with inflammatory bowel disease (IBD) …
The gut microbiota-bile acid axis: a crucial regulator of immune function and metabolic health
Publication Year: 2025 Source: World J Microbiol Biotechnol PMID: 40555888
The gut microbiota and bile acid metabolism are intricately linked, playing a crucial role in immune regulation, metabolic processes, and overall health. The gut microbiome, consisting of diverse bacterial genera such as Bacteroides, Clostridium, Lactobacillus, Bifidobacterium, and Eubacterium, facilitates the conversion of primary bile acids into secondary bile acids through …
Transforming IBD care: the future of personalized therapy through multi-omics and pharmacogenomics
Publication Year: 2025 Source: Expert Opin Drug Metab Toxicol PMID: 40556317 DOI: 10.1080/17425255.2025.2521048
INTRODUCTION: Inflammatory bowel disease (IBD) treatment remains challenging, with many patients experiencing suboptimal responses despite advances in therapies. This necessitates more precise and personalized approaches. AREAS COVERED: A literature search was conducted using Embase, Scopus, and PubMed (January 2000-March 2024) with keywords such as 'inflammatory bowel disease,' 'pharmacogenomics,' 'multi-omics,' and …
Prostaglandins and Inflammatory Bowel Disease: From Mechanism to Clinic
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40556439 DOI: 10.1093/ibd/izaf121
Inflammatory bowel disease (IBD), mainly consisting of ulcerative colitis and Crohn's disease, represents a multifaceted and chronic inflammatory disorder that has arisen as a critical public health challenge globally. The underlying mechanisms of IBD are not fully elucidated, involving a complex interaction among various elements, such as genetic predispositions, environmental …
Long-Term Outcome of Colonic and Ileal Crohn's Disease: A Two-Decade Population-Based Study in Pediatric-Onset Disease
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40556440 DOI: 10.1093/ibd/izaf133
INTRODUCTION: Crohn's disease (CD) location would influence the risk of complications and therapeutic strategies. The objective of this study was to compare the clinical presentation at diagnosis and the natural history of colonic CD in comparison to ileal CD and ulcerative colitis (UC) in pediatric-onset inflammatory bowel disease (IBD). PATIENTS …
Early Top-Down Treatment With Biologics Improves the Rates of Transmural Remission in Crohn's Disease-A Risk-Adjusted Propensity Score Matched Analysis
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40556511
BACKGROUND: Early top-down treatment with biologics has been associated with higher rates of endoscopic remission compared to step-up treatment in Crohn's disease (CD). The benefits in relation to transmural remission are currently unknown. Better stratification of patients suitable for top-down strategies is needed. METHODS: Retrospective study including CD patients naive …
Pou2af1 Deficiency Aggravates DSS-Induced Colitis via Impaired Germinal Center Responses and Altered Gut Microbiota
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40556523
BACKGROUND: Bob1 plays a critical role in immune system regulation, particularly in the function of B cells. Its deficiency in the context of colitis remains underexplored. This study investigates the effects of Bob1 (Pou2af1) deficiency on colitis, particularly focusing on immune responses and gut microbiota alterations in a murine model. …
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