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CO-Releasing Polyoxometalates Nanozyme with Gut Mucosal Immunity and Microbiota Homeostasis Remodeling Effects for Restoring Intestinal Barrier Integrity
Publication Year: 2025 Source: Adv Sci (Weinh) PMID: 40079617 DOI: 10.1002/advs.202500116
Disruption of the intestinal epithelial barrier, driven by imbalances in gut mucosal immunity and microbial homeostasis, is central to the onset and progression of inflammatory bowel disease (IBD). This study introduces a CO-releasing polyoxometalates (POMs) nanozyme (PMC), synthesized by coordinating pentacarbonyl manganese bromide with molybdenum-based POM nanoclusters. PMC demonstrates targeted …
Contrast-enhanced ultrasound of Crohn's disease in children and young adults: quantitative metric correlations and MRI disease severity associations
Publication Year: 2025 Source: Pediatr Radiol PMID: 40080165
BACKGROUND: There is a paucity of data comparing contrast-enhanced ultrasound (CEUS) to MR enterography in children and young adults with Crohn's disease. OBJECTIVE: To measure correlations across CEUS quantitative metrics in children and young adults with Crohn's disease, and to evaluate if these metrics are associated with MRI features of …
Correction to: Correlation Between Serum and Fecal Biomarkers and Patient‑Reported Outcomes in Patients with Crohn's Disease and Ulcerative Colitis
Publication Year: 2025 Source: Dig Dis Sci PMID: 40080245 DOI: 10.1007/s10620-025-08963-7
No Abstract
Endoscopic stricturotomy for inflammatory bowel disease strictures in anatomically challenging locations (deep small bowel, duodenum, anal canal and pouch): A case series with technical review (with videos)
Publication Year: 2025 Source: Indian J Gastroenterol PMID: 40080373
No Abstract
Improving Brain-Gut Studies in Crohn's Disease: Methodological Considerations
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40080843
No Abstract
Total Proctocolectomy Versus Subtotal/Total Colectomy for Neoplasia in Patients With Inflammatory Bowel Disease and Primary Sclerosing Cholangitis
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40080845
No Abstract
Reply to "Improving Brain-Gut Studies in Crohn's Disease: Methodological Considerations"
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40080846
No Abstract
Antibiotic Prophylaxis in Obstetrics and Gynecology: A Comparative Review of Guidelines
Publication Year: 2025 Source: Obstet Gynecol Surv PMID: 40080893
IMPORTANCE: The administration of prophylactic antibiotics in obstetrics and gynecology represents a pivotal intervention with a major contribution to the prevention of maternal and neonatal infectious morbidity. OBJECTIVES: The aim of this study was to review and compare the most recently published guidelines on prophylactic antibiotic use in obstetric and …
Lactylation-related molecular subtyping reveals the immune heterogeneity and clinical characteristics in ulcerative colitis
Publication Year: 2025 Source: Biochem Biophys Res Commun PMID: 40081238
BACKGROUND: Ulcerative colitis (UC) is a chronic inflammatory disease linked to early-onset colorectal cancer and metabolic abnormalities. While intestinal lactate disturbances are observed in UC, the role of lactate and lactylation in its pathogenesis remains unclear. The lack of specific biomarkers reflecting these processes limits understanding of their biological significance. …
Piezo1-specific Deletion in Macrophage Protects the Progression of Chronic Inflammatory Bowel Disease in Mice
Publication Year: 2025 Source: Cell Mol Gastroenterol Hepatol PMID: 40081571 DOI: 10.1016/j.jcmgh.2025.101495
BACKGROUND & AIMS: Piezo1, a recently identified mechanically activated nonselective cation channel protein, demonstrates sensitivity to various mechanical stimuli, such as matrix stiffness and shear stress. Although accumulating evidence implicates Piezo1 channels in numerous physiologic and pathophysiologic processes, its involvement in dextran sulfate sodium (DSS)-induced acute and chronic inflammatory bowel …
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