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Colitis can reduce the cingulate cortex neuronal density in rats
Publication Year: 2025 Source: BMC Gastroenterol PMID: 40082771 DOI: 10.1186/s12876-025-03745-x
BACKGROUND AND AIM: Hyperalgesia and hypersensitivity in patients with Inflammatory Bowel Disease (IBD) can be related to central nervous system (CNS) changes, particularly in the pain pathways. The objective of this study was to examine the neuronal density of the cingulate cortex area (CC) and amygdala in an animal model …
Utilization of Super-Resolution Contrast-Enhanced Ultrasonography in Diagnosing Intestinal Behçet's Disease With Enterovesical Fistula
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40083056
No Abstract
Faecal Cytolysin is Associated With Worse Survival in Patients With Primary Sclerosing Cholangitis
Publication Year: 2025 Source: Liver Int PMID: 40083245 DOI: 10.1111/liv.16181
BACKGROUND AND AIMS: Primary sclerosing cholangitis (PSC) is an immune-related cholangiopathy without treatment options beyond liver transplantation. The gut-liver axis, especially the role of gut microbes, has emerged as a crucial pathway contributing to PSC pathogenesis. Recent research has revealed Enterococcus (E.) faecalis and its virulence factor cytolysin to increase …
Risk Factors for Contraceptive Failure and Unintended Pregnancy Among Women With Inflammatory Bowel Disease
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40084521 DOI: 10.1093/ibd/izaf046
No Abstract
Platelet activation stimulates macrophages to enhance ulcerative colitis through PF4/CXCR3 signaling
Publication Year: 2025 Source: Int J Mol Med PMID: 40084691
Platelets are involved in hemostasis and immune regulation, but little is currently known regarding their role in inflammatory bowel disease. In the present study, the mechanism by which platelet activation affects macrophage C‑X‑C motif chemokine receptor 3 (CXCR3) by releasing platelet factor 4 (PF4), thus aggravating ulcerative colitis (UC) disease …
Applicability of colon capsule endoscopy for monitoring ulcerative colitis: a systematic review
Publication Year: 2025 Source: Scand J Gastroenterol PMID: 40084907
BACKGROUND: As the target of therapy in Ulcerative colitis (UC) has changed from symptomatic relief to mucosal healing, endoscopic visualization is mandatory. Colon capsule endoscopy (CCE) may serve as a less invasive and more tolerable alternative to standard colonoscopy (SC) for the monitoring of UC. OBJECTIVES: To evaluate the diagnostic …
Ferroptosis-Related Genes Are Effective Markers for Diagnostic Targets of Crohn's Disease
Publication Year: 2025 Source: Immun Inflamm Dis PMID: 40084946
INTRODUCTION: Crohn's disease (CD) is a group of chronic transmural inflammation of gastrointestinal tract, which seriously harms the mental and physical health of adolescents. At present, there are still no specific markers that make the diagnosis of CD extremely difficult and poor prognosis. Iron deficiency is common in CD, yet …
TXM-CB13 Improves the Intestinal Mucosal Barrier and Alleviates Colitis by Inhibiting the ROS/TXNIP/TRX/NLRP3 and TLR4/MyD88/NF-κB/NLRP3 Pathways
Publication Year: 2025 Source: Inflammation PMID: 40085192 DOI: 10.1007/s10753-025-02282-9
The activation of inflammasomes (NLRP3 and NLRP1) is central to the pathogenesis of inflammatory bowel disease (IBD). Here we examined the protective effects of a thioredoxin-mimetic peptide CB13 (TXM-CB13), known for its antioxidative stress and anti-inflammatory properties. We examined the effects of TXM-CB13 on dextran sulfate sodium (DSS)-induced colitis and …
The interrelationship between intestinal immune cells and enteric α-synuclein in the progression of Parkinson's disease
Publication Year: 2025 Source: Neurol Sci PMID: 40085320
Parkinson's disease (PD) is a neurodegenerative disorder primarily characterized by motor impairment, resulting from the accumulation of alpha-synuclein and neuronal cell death in the substantia nigra of the midbrain. Emerging evidence suggests that alpha-synuclein aggregation may originate in the enteric nervous system (ENS) and subsequently propagate to the brain via …
Systematic Identification of Mitochondrial Signatures in Alzheimer's Disease and Inflammatory Bowel Disease
Publication Year: 2025 Source: Mol Neurobiol PMID: 40085351 DOI: 10.1007/s12035-025-04826-4
Mitochondrial dysfunction is increasingly recognized as a shared feature of Alzheimer's disease (AD) and inflammatory bowel disease (IBD), linked through overlapping pathways of hypoxia and immune dysregulation. Our study integrated transcriptomic and genetic analyses to uncover mitochondria-related mechanisms underlying these diseases. By analyzing multiple AD and IBD datasets through differential …
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