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One Year Follow Up of Endovascular Repair of Aorto-iliac or Iliac Aneurysms using the E-iliac Stent Graft System: An E-volution?

Publication Year: 2025 Source: Eur J Vasc Endovasc Surg PMID: 40044023 DOI: 10.1016/j.ejvs.2025.02.042

No Abstract

Sodium butyrate alleviates colitis by inhibiting mitochondrial ROS mediated macrophage pyroptosis

Publication Year: 2025 Source: Biochim Biophys Acta Mol Basis Dis PMID: 40044062 DOI: 10.1016/j.bbadis.2025.167756

Inflammatory bowel disease (IBD) is a chronic inflammatory bowel disease with unclear causes and limited treatment options. Sodium butyrate (NaB), a byproduct of dietary fiber in the intestine, has demonstrated efficacy in treating inflammation. However, the precise anti-inflammatory mechanisms of NaB in colon inflammation remain largely unexplored. This study aims …

Risk factors for difficult endoscopic bowel dilation of predominantly shorter and noninflammatory strictures among patients with inflammatory bowel disease: findings from inflammatory bowel disease tertiary centers in Poland and Czech Republic

Publication Year: 2025 Source: Gastrointest Endosc PMID: 40044092 DOI: 10.1016/j.gie.2025.02.036

BACKGROUND AND AIMS: Intestinal strictures are a common and serious adverse event of inflammatory bowel disease (IBD). Endoscopic balloon dilation (EBD) is the first step in treatment to avoid surgery. The aim of this study was to assess the prevalence, risk factors, and clinical sequelae of difficult EBD. METHODS: This …

CaGA nanozymes inhibit oxidative stress and protect mitochondrial function in ulcerative colitis therapy

Publication Year: 2025 Source: Acta Biomater PMID: 40044102

Ulcerative colitis (UC) is a long-term inflammatory bowel disease characterized by intense inflammation of the colorectal mucosa. Overproduction of reactive oxygen species exacerbates the progression of UC, which is linked to mitochondrial impairment and dysbiosis of the intestinal microbiota. CaGA nanozymes have demonstrated efficacy in the treatment of UC. The …

Optimal Pouch Training: Investigating Operative and Nonoperative Needs Study

Publication Year: 2025 Source: Dis Colon Rectum PMID: 40044400 DOI: 10.1097/DCR.0000000000003685

BACKGROUND: Ileal pouch anal anastomosis is an important part of colorectal surgery training. However, decreasing case numbers create fewer chances to teach the knowledge and skills to trainees. OBJECTIVE: The purpose of this study is to define the components and format of an adjunctive curriculum for teaching colon and rectal …

Long-term outcomes of a bioactive matrix enriched with an autologous platelet concentrate for the treatment of complex anal fistulae

Publication Year: 2025 Source: Tech Coloproctol PMID: 40044989

BACKGROUND: Treating complex anal fistulae (CAF) remains a clinical challenge. Regenerative fistula treatment (RFT) with a bioactive matrix enriched with autologous platelet concentrate (Obsidian RFT(R)) has shown potential in healing CAF while preserving continence, but its long-term efficacy is still debated. This study aims to report the outcomes of RFT …

Cost-of-illness analysis of ulcerative colitis patients treated with biological therapy: a prospective observational study in Iran

Publication Year: 2025 Source: BMC Health Serv Res PMID: 40045278

BACKGROUND: No research has assessed the comprehensive annual costs of managing ulcerative colitis (UC) patients undergoing biological treatment. This study aimed to determine the annual costs and primary cost drivers for UC patients receiving biological therapy. METHODS: This prospective observational study was conducted in Iran from a societal perspective, employing …

Salivary shield: Rhodnius prolixus salivary glandular extract reduces intestinal immunopathology and protects against Toxoplasma gondii infection

Publication Year: 2025 Source: Gut Pathog PMID: 40045369

C57BL/6 mice, orally infected with T. gondii, experience pronounced severe intestinal inflammation, causing necrosis, weight loss, and bacterial translocation. In addition, immunomodulatory molecules such as lipocalins, nitrophorins, and apyrases are present in R. prolixus saliva. Our objective was to assess the immunomodulatory effects of the salivary gland extract (SGE) of …

SAPHO syndrome with bone destruction in the lumbar vertebral endplates: a case report

Publication Year: 2025 Source: Mod Rheumatol Case Rep PMID: 40045589

SAPHO syndrome is a rare inflammatory osteoarticular disorder, which includes autoimmune diseases such as pustulotic arthro-osteitis, inflammatory bowel disease-associated spondyloarthritis, and psoriatic arthritis. There are few reports on the treatment of SAPHO syndrome that presents with bone destruction in the spine. We present a case in which adalimumab (ADA) was …

Ulcerative Colitis Gone Rogue: A Case of Complement-Mediated Thrombotic Microangiopathy in Inflammatory Bowel Disease

Publication Year: 2025 Source: Cureus PMID: 40046371

We present an unusual case of complement-mediated thrombotic microangiopathy (formerly known as atypical hemolytic uremic syndrome) associated with inflammatory disease in a young patient. A 26-year-old male patient with no significant past medical history presented to our emergency department with a four-week history of diffuse, moderate, cramping, non-radiating abdominal pain …

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