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Beyond Inflammatory Bowel Disease: Calprotectin as a Marker for Trichobezoar? A Case Report
Publication Year: 2025 Source: Case Rep Gastroenterol PMID: 40556638 DOI: 10.1159/000546623
No Abstract
The impact of artificial intelligence on the endoscopic assessment of inflammatory bowel disease-related neoplasia
Publication Year: 2025 Source: Therap Adv Gastroenterol PMID: 40556746 DOI: 10.1177/17562848251348574
Inflammatory bowel disease (IBD) is a group of chronic inflammatory conditions of the gastrointestinal tract resulting from an inappropriate immune response to an altered gut microbiome in genetically predisposed individuals. Endoscopy plays a central role in IBD management, aiding in diagnosis, disease staging, monitoring, and therapeutic guidance. Patients with IBD …
Gut health predictive indices linking gut microbiota dysbiosis with healthy state, mild gut discomfort, and inflammatory bowel disease phenotypes using gut microbiome profiling
Publication Year: 2025 Source: Microbiol Spectr PMID: 40558050
Despite the complexity of the gut microbiome, several scores that use taxonomic characteristics exist that attempt to identify a healthy gut or gastrointestinal disease. Two systems in use are the metagenomic aerotolerant predominance index (MAPI) and keystone scores. The aim of this analysis was to compare different gut microbiome scores, …
Bacteroides Fragilis-Derived Outer Membrane Vesicles Deliver MiR-5119 and Alleviate Colitis by Targeting PD-L1 to Inhibit GSDMD-Mediated Neutrophil Extracellular Trap Formation
Publication Year: 2025 Source: Adv Sci (Weinh) PMID: 40558568 DOI: 10.1002/advs.202500781
Inflammatory bowel disease (IBD) results from a breakdown in the symbiotic relationship between the intestinal commensal microflora and the mucosal immune system. Non-toxigenic Bacteroides fragilis, a common human colon symbiote, has been shown to alleviate colitis. However, the underlying mechanisms of this alleviation remain incompletely understood. Herein, it is demonstrated …
The Hidden Burden: Gastrointestinal Involvement in Lysosomal Storage Disorders
Publication Year: 2025 Source: Metabolites PMID: 40559385
BACKGROUND: Lysosomal storage disorders (LSDs) are rare inherited metabolic diseases characterized by defects in lysosomal enzyme function or membrane transport. These defects lead to substrate accumulation and multisystemic manifestations. This review focuses on gastrointestinal (GI) involvement in LSDs, which is a significant but often overlooked aspect of these disorders. METHODS: …
Network Toxicology and Molecular Docking to Elucidate the Mechanisms of Intestinal Toxicity Induced by P-Phenylenediamine Antioxidants and Their Quinone Derivatives
Publication Year: 2025 Source: Toxics PMID: 40559953
P-phenylenediamines (PPDs) and their quinone derivatives (PPDQs), emerging pollutants widespread in urban environments, exhibit biotoxicological risks. Epidemiological studies suggest their adverse impacts on intestinal health, yet the underlying mechanisms remain unclear. This study aimed to investigate the potential mechanisms of enterotoxicity induced by 13 PPDs and PPDQs using network toxicology …
Exploring Nutritional Counseling for Inflammatory Bowel Disease: A Review Based on WH Questions
Publication Year: 2025 Source: Nutr Rev PMID: 40560138 DOI: 10.1093/nutrit/nuaf071
OBJECTIVES: The evidence supporting nutritional counseling (NC) as a care strategy for inflammatory bowel disease (IBD) was evaluated in this review. Using a "WH" (what, why, which/where, who, when, and who/for whom) question approach, the review is structured around key questions that prompt detailed answers, providing insights into how NC …
A Prospective Comparison of Ustekinumab and Anti-TNF Therapy in the Treatment of Crohn's-like Disease of the Pouch
Publication Year: 2025 Source: Am J Gastroenterol PMID: 40560215
BACKGROUND: Many patients with chronic pouchitis and Crohn's-like disease of the pouch (CLDP) are treated with biologics; however, the comparative effectiveness of advanced therapies in this population has not been systematically evaluated. We sought to compare the effectiveness of anti-tumor necrosis factor alpha (anti-TNF) therapies and ustekinumab in patients with …
Risk profile of promoters and inhibitors of kidney stone formation in paediatric inflammatory bowel disease
Publication Year: 2025 Source: Pediatr Nephrol PMID: 40560272 DOI: 10.1007/s00467-025-06851-w
BACKGROUND: Nephrolithiasis is a well-known extraintestinal complication of adult inflammatory bowel disease (IBD), mainly attributed to hyperoxaluria. In contrast, data for paediatric IBD are limited. The objective of this study was to evaluate renal stone risk in children and adolescents with IBD by analysing urine composition concerning stone promoters and …
Starvation activates ECM-remodeling gene transcription and putative enhancers in fibroblasts despite inducing quiescence
Publication Year: 2025 Source: Cell Rep PMID: 40560730 DOI: 10.1016/j.celrep.2025.115896
Depletion of growth factors and nutrients induces cellular quiescence, which often accompanies transcriptional silencing and chromatin compaction. Paradoxically, such depletion occurs in pathological microenvironments in which fibroblasts are activated to orchestrate tissue remodeling. The relationship between fibroblast activation and growth factor and nutrient depletion remains unclear. Here, we report that …
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