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Higher dietary glycemic index, but not glycemic load, is associated with increased risk of ulcerative colitis: a prospective cohort study
Publication Year: 2025 Source: J Crohns Colitis PMID: 40048698 DOI: 10.1093/ecco-jcc/jjaf036
BACKGROUND AND AIMS: Total carbohydrate intake has been inconsistently associated with inflammatory bowel disease (IBD) risk in previous epidemiological studies. We aimed to evaluate the effects of glycemic index and glycemic load, 2 main indicators for measuring the quality and quantity of carbohydrates, on the risk of IBD subtypes (ie, …
Maternal and Neonatal Hemorrhage From Vitamin K Deficiency in the Setting of Crohn Disease in Pregnancy
Publication Year: 2025 Source: Obstet Gynecol PMID: 40048733
BACKGROUND: Patients with inflammatory bowel disease, particularly Crohn disease (CD), are at increased risk of fat malabsorption and fat-soluble vitamin deficiencies. Vitamin K is a fat-soluble vitamin that plays a critical role in blood coagulation. Vitamin K deficiency during pregnancy can lead to severe maternal and neonatal hemorrhagic complications. CASE: …
Exploring diet categorizations and their influence on flare prediction in inflammatory bowel disease, using the Sparse Grouped Least Absolute Shrinkage and Selection Operator method
Publication Year: 2025 Source: Clin Nutr PMID: 40048994 DOI: 10.1016/j.clnu.2025.02.027
BACKGROUND & AIMS: Diet is an important environmental factor in inflammatory bowel disease (IBD) onset and disease course, but analyses are hindered by its complexity. We aim to explore the Sparse Grouped Least Absolute Shrinkage and Selection Operator (Sparse Grouped LASSO or SGL) method to study whether different food categorizations, …
Btbd8 deficiency exacerbates bleomycin-induced pulmonary fibrosis in mice by enhancing myofibroblast accumulation and inflammatory responses
Publication Year: 2025 Source: Exp Cell Res PMID: 40049313
BTBD8 contributes to the pathogenesis of inflammatory bowel disease through regulating intestinal barrier integrity and inflammation. However, its role in idiopathic pulmonary fibrosis (IPF) remains unknown. Here we investigated whether BTBD8 plays a role in bleomycin-induced pulmonary fibrosis. Pulmonary fibrosis was induced in wild-type (WT) and Btbd8 knockout (KO) mice …
Polygonatum cyrtonema Hua polysaccharide alleviates ulcerative colitis via gut microbiota-independent modulation of inflammatory immune response
Publication Year: 2025 Source: Carbohydr Polym PMID: 40049966
Polygonatum cyrtonema polysaccharides (PCP) exhibit ameliorative effects on colitis. However, whether the protective effects of PCP depend on the gut microbiota and how PCP regulates intestinal immune responses to alleviate colitis remain unclear. Therefore, this study investigated the effect of PCP against colitis focusing on the regulation of intestinal immune …
[Characteristics and prognosis of patients with primary sclerosing cholangitis]
Publication Year: 2025 Source: Zhonghua Nei Ke Za Zhi PMID: 40050087
Objective: Primary sclerosing cholangitis (PSC) is a rare autoimmune disease. This study aims to describe the baseline characteristics and clinical outcomes of Chinese PSC patients and explore risk factors associated with prognosis, addressing the lack of long-term prognostic analysis in China. Methods: Clinical data of PSC patients were retrospectively collected …
In vitro and in vivo effects of Centella asiatica on intestinal inflammatory models and identification of its bioactive components
Publication Year: 2025 Source: J Sci Food Agric PMID: 40050134
BACKGROUND: The family Apiaceae (genus Centella) includes approximately 50 species, many of which are used in traditional medicine to treat various inflammatory diseases. Traditionally, Centella asiatica has been widely used as a medicinal herb in Ayurvedic medicine. The efficacy of C. asiatica in treating intestinal inflammation remains poorly explored. RESULTS: …
Pregnancy and perinatal outcomes of mothers with inflammatory bowel disease in Taiwan: A national database analysis
Publication Year: 2025 Source: J Formos Med Assoc PMID: 40050214 DOI: 10.1016/j.jfma.2025.02.034
BACKGROUND: Pregnant women with inflammatory bowel disease frequently experience suboptimal perinatal outcomes. One Taiwanese study conducted from 2001 to 2003 revealed higher risks of preterm birth and low birth weight in infants born to mothers with ulcerative colitis. With the advancement in disease management, we aim to investigate the pregnancy …
A systematic review of digital and imaging technologies for measuring fatigue in immune mediated inflammatory diseases
Publication Year: 2025 Source: NPJ Digit Med PMID: 40050401
Chronic fatigue greatly impacts the quality of life in individuals with immune-mediated inflammatory disease (IMID). Currently, fatigue assessment relies on patient-reported outcome (PRO) questionnaires. A systematic review following PRISMA guidelines was conducted to explore how digital and imaging technologies have been used to measure fatigue. PubMed and Cochrane Library were …
Prevalence and predictability of the Chicago Classification of Pouchitis in ulcerative colitis: a multicenter study in Japan
Publication Year: 2025 Source: J Gastroenterol PMID: 40050487
BACKGROUND: Endoscopic phenotypes of pouchitis according to the Chicago Classification have been reported to be associated with poor pouch outcomes in ulcerative colitis (UC). Here, we aimed to assess the prevalence of endoscopic phenotypes and their predictability for pouch outcomes. METHODS: This retrospective multicenter study included UC patients aged 18 …
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