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Healthcare professionals' knowledge, attitude and practice towards ischemic bowel disease
Publication Year: 2025 Source: World J Gastrointest Surg PMID: 40061978 DOI: 10.4240/wjgs.v17.i2.96493
BACKGROUND: Ischemic bowel disease (IBD) is a critical condition caused by reduced blood flow to the intestines, leading to tissue damage and potentially severe complications. Early recognition and timely management are essential for improving patient outcomes and reducing morbidity and mortality associated with IBD. AIM: To evaluate the knowledge, attitude …
Application of Saccharomyces boulardii in combination with sulfasalazine in ulcerative colitis patients demonstrates significant effectiveness
Publication Year: 2025 Source: World J Gastrointest Surg PMID: 40061979
BACKGROUND: Ulcerative colitis (UC) is a complex inflammatory bowel disease, and its etiology and pathogenesis remain incompletely elucidated. AIM: To analyze the effects of Saccharomyces boulardii in combination with sulfasalazine on intestinal microbiota and intestinal barrier function in patients with UC. METHODS: A retrospective analysis of clinical data from 127 …
Preliminary study on the clinical value of endoscopic stricturotomy in the treatment of stricturing Crohn's disease
Publication Year: 2025 Source: World J Gastrointest Surg PMID: 40062003
BACKGROUND: Crohn's disease (CD) frequently leads to intestinal strictures, which pose significant challenges due to their complexity and limited treatment options. While medications can address inflammatory strictures, they are largely ineffective for fibrotic and mixed strictures, often necessitating surgical intervention. However, surgery carries considerable risks, including bleeding, infection, anastomotic leaks, …
Bowel Obstruction Due to the Mesenteric Mass Being an Enteritis Cystica Profunda: A Case Report
Publication Year: 2025 Source: Cureus PMID: 40062087
Enteritis cystica profunda (ECP) is a rare benign condition characterized by mucin-filled cystic spaces in the submucosal layer of the small intestine. It is often associated with inflammatory conditions, such as Crohn's disease. This case report describes a 47-year-old male with a history of diabetes and hypertension who presented with …
Mechanism of Wuling powder modulating proBDNF/p75NTR/sortilin and BDNF/TrkB pathways in the treatment of ulcerative colitis complicated with depression
Publication Year: 2025 Source: World J Gastroenterol PMID: 40062332
BACKGROUND: Ulcerative colitis (UC) is a chronic inflammatory disease affecting the colon. The most common psychological issue in UC patients is varying degrees of depression, which affects the condition and quality of life of UC patients and may lead to deterioration of the patient's condition. UC drugs combined with antianxiety …
Glial cell line-derived neurotrophic factor improves impaired colonic motility in experimental colitis mice through connexin 43
Publication Year: 2025 Source: World J Gastroenterol PMID: 40062335
BACKGROUND: Colonic motility dysfunction is a common symptom of ulcerative colitis (UC), significantly affecting patients' quality of life. Evidence suggests that glial cell line-derived neurotrophic factor (GDNF) plays a role in restoring colonic function. AIM: To investigate whether GDNF enhances aberrant colonic motility in mice with experimental colitis via connexin …
Microbiota transplant therapy in inflammatory bowel disease: advances and mechanistic insights
Publication Year: 2025 Source: Gut Microbes PMID: 40062406
Microbiota transplant therapy is an emerging therapy for inflammatory bowel disease, but factors influencing its efficacy and mechanism remain poorly understood. In this narrative review, we outline key elements affecting therapeutic outcomes, including donor factors (such as age and patient relationship), recipient factors, control selection, and elements impacting engraftment and …
The spatiotemporal development of mesenteric lymphatic changes in the TNF(ΔARE/+) mouse model of terminal ileitis
Publication Year: 2025 Source: Am J Physiol Gastrointest Liver Physiol PMID: 40062472
Crohn's disease (CD) is a chronic inflammatory bowel disease, which also encompasses significant alterations of the mesenteric lymphatic system. Whether these changes are a mere consequence of or directly contribute to the inflammation is unknown. Here, we characterized the spatial and temporal development of these events in the TNF(DeltaARE/+) mouse, …
The physical biogeography of Fusobacterium nucleatum in health and disease
Publication Year: 2025 Source: mBio PMID: 40062772
Fusobacterium nucleatum (Fn) is an oral commensal inhabiting the human gingival plaque that is rarely found in the gut. However, in colorectal cancer (CRC), Fn can be isolated from stool samples and detected in metagenomes. We hypothesized that ecological characteristics of the gut are altered by disease, enabling Fn to …
Integrating multi-omics data to reveal the host-microbiota interactome in inflammatory bowel disease
Publication Year: 2025 Source: Gut Microbes PMID: 40063366 DOI: 10.1080/19490976.2025.2476570
Numerous studies have accelerated the knowledge expansion on the role of gut microbiota in inflammatory bowel disease (IBD). However, the precise mechanisms behind host-microbe cross-talk remain largely undefined, due to the complexity of the human intestinal ecosystem and multiple external factors. In this review, we introduce the interactome concept to …
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