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Upadacitinib Results in Endoscopic Remission in Patients With Inflammatory Bowel Disease and Prior Tofacitinib Failure
Publication Year: 2025 Source: J Clin Gastroenterol PMID: 40063408
GOALS: Assess the safety and effectiveness of upadacitinib in patients with prior tofacitinib failure. BACKGROUND: Patients with severe, refractory Crohn's disease (CD) or ulcerative colitis (UC) and inadequate response to medical therapy have a high risk of complications. A better understanding of treatment response in the setting of prior failure …
Decoding Learner Behavior in Virtual Reality Education: Insights from Epistemic Network Analysis and Differential Sequence Mining
Publication Year: 2025 Source: IEEE Trans Vis Comput Graph PMID: 40063483 DOI: 10.1109/TVCG.2025.3549899
The integration of immersive Virtual Reality (I-VR) technology in education has emerged as a promising approach for enhancing learning experiences. There is a handful of research done to study the impact of I-VR on learning outcomes, comparison of learning using I-VR and other traditional learning methods, and the impact of …
Longitudinal Monitoring of Inflammatory Bowel Disease in Mice Using Endoscopic Optical Coherence Tomography
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40063581 DOI: 10.1093/ibd/izaf045
BACKGROUND: Inflammatory bowel disease (IBD) is one of the fastest-growing diseases globally. Nearly 5 million people are affected by IBD, with an incremental growth rate of 47.45% between 1990 and 2019. AIM AND METHODS: We aim to provide a noninvasive approach to detecting IBD with an in-house developed 1310 nm …
Prevalence of Irritable Bowel Syndrome Based on Rome IV Criteria in Patients in Biochemical and Endoscopic Remission From Newly Diagnosed Inflammatory Bowel Disease: One- and Three-Year Results (the IBSEN III Cohort)
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40063582 DOI: 10.1093/ibd/izaf047
BACKGROUND: Distinguishing irritable bowel syndrome (IBS) from inflammatory bowel disease (IBD) flare-ups is challenging. This study used objective remission markers to accurately determine IBS prevalence in a population-based cohort of patients with IBD. METHODS: Adults with ulcerative colitis and Crohn's disease were recruited from the IBD in South-Eastern Norway III …
The Role of Human Leukocyte Antigen Alleles and Maternal Microchimerism in Very-Early-Onset Ulcerative Colitis in Japanese Children
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40063588
BACKGROUND: Very-early-onset ulcerative colitis (VEO-UC) is a severe form of inflammatory bowel disease that manifests before the age of 6 years. Compared to typical pediatric UC, it is characterized by distinct genetic and immunological factors. This study aimed to investigate the roles of specific human leukocyte antigen (HLA) alleles and …
Role of Mushroom Polysaccharides in Modulation of GI Homeostasis and Protection of GI Barrier
Publication Year: 2025 Source: J Agric Food Chem PMID: 40063730
Edible and medicinal mushroom polysaccharides (EMMPs) have been widely studied for their various biological activities. It has been shown that EMMPs could modulate microbiota in the large intestine and improve intestinal health. However, the role of EMMPs in protecting the gastric barrier, regulating gastric microbiota, and improving gastric health cannot …
Nutrition and dietary therapy in paediatric inflammatory bowel disease
Publication Year: 2025 Source: Clin Nutr ESPEN PMID: 40064235
No Abstract
Habitual intake of macronutrients and fermentable oligo-, di-, monosaccharides and polyols is not associated with irritable bowel syndrome-like symptoms in inflammatory bowel disease
Publication Year: 2025 Source: Clin Nutr ESPEN PMID: 40064237 DOI: 10.1016/j.clnesp.2025.03.005
PURPOSE: Almost a third of patients with inactive inflammatory bowel disease (IBD) suffer from symptoms compatible with irritable bowel syndrome (IBS-like symptoms). The relation between these symptoms and diet in patients with IBD is not fully established. We aimed to assess associations between IBS-like symptoms and intake of macronutrients and …
Inhibitory Effects of Lysophospholipids on Survival and Interleukin-8 Secretion of HT-29, a Human Colon Cancer-Derived Epithelial Cell
Publication Year: 2025 Source: Biol Pharm Bull PMID: 39956589
Lysophpsphospholipids (LPLs) are lipid mediators involved in various physiological functions. In daily diets, people consume large amounts of various lipids, including LPLs. Exogenous dietary LPLs initially affect epithelial cells and, finally, the entire colon and may be linked to the onset and prevention of colonic diseases, including inflammatory bowel disease. …
Tissue factor-dependent colitogenic CD4(+) T cell thrombogenicity is regulated by activated protein C signalling
Publication Year: 2025 Source: Nat Commun PMID: 39956825 DOI: 10.1038/s41467-025-57001-7
Patients with inflammatory bowel disease (IBD) have an increased risk of venous thromboembolism (VTE), but the underlying mechanistic basis remains poorly defined. Here, we find that colitogenic CD4(+) T cells express tissue factor (TF) and promote rapid TF-dependent plasma thrombin generation. TF(+)CD3(+)CD4(+) T cells are present in both the colons …
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