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Unraveling the causal association between inflammatory bowel diseases and uveitis through mendelian randomization analysis
Publication Year: 2025 Source: Sci Rep PMID: 39956872 DOI: 10.1038/s41598-025-90462-w
To investigate the causal relationship between inflammatory bowel disease (IBD) and uveitis, we conducted a two-sample bidirectional Mendelian randomization (MR) analysis utilizing summary data from genome-wide association studies (GWAS). The primary statistical analysis was performed using the inverse-variance weighted (IVW) method. False discovery rate (FDR) correction was used to control …
Microbiota-derived IPA alleviates intestinal mucosal inflammation through upregulating Th1/Th17 cell apoptosis in inflammatory bowel disease
Publication Year: 2025 Source: Gut Microbes PMID: 39956891 DOI: 10.1080/19490976.2025.2467235
The gut microbiota-derived metabolite indole-3-propionic acid (IPA) plays an important role in maintaining intestinal mucosal homeostasis, while the molecular mechanisms underlying IPA regulation on mucosal CD4(+) T cell functions in inflammatory bowel disease (IBD) remain elusive. Here we investigated the roles of IPA in modulating mucosal CD4(+) T cells and …
Clinoptilolite in the drug refractory chronic diarrhoea
Publication Year: 2025 Source: Clin Ter PMID: 39957445
OBJECTIVE: The aim of study was to assess the safety and tolerability of a specific zeolite powder (Xeoderm powder, Phytoitalia S.r.l -Corbetta, Italy) and its effectiveness on health-related quality of life, bowel habits, psychological status (i.e., anxiety, depression, and stress). MATERIALS AND METHODS: 100 patients affected by inadequately treated chronic …
The ulcerative colitis risk gene adenylyl cyclase 7 restrains the T-helper 2 phenotype and Class II antigen presentation
Publication Year: 2025 Source: J Crohns Colitis PMID: 39957491
BACKGROUND AND AIMS: Genome-wide association studies have shown that the most risk-conferring genetic polymorphism for ulcerative colitis (UC) outside the human leukocyte antigen locus is the amino acid substitution p.Asp439Glu in the adenylyl cyclase 7 gene (ADCY7). ADCY7 is the main isoform in the hematopoietic system and produces the second …
Harnessing Akkermansia muciniphila Membrane Coating for Probiotic Therapy in Inflammatory Bowel Disease
Publication Year: 2025 Source: ACS Appl Mater Interfaces PMID: 39957560 DOI: 10.1021/acsami.4c18134
Inflammatory bowel diseases (IBDs) are characterized by dysregulated inflammatory responses, increased reactive oxygen species (ROS), and compromised intestinal barrier function. Current clinical treatments often yield suboptimal responses and significant side effects. Given the great potential of Akkermansia muciniphila (AKK) bacterial membrane components in IBD treatment and the possible pathogenicity of …
Association of Healthy Lifestyle Behaviours With Incident Inflammatory Bowel Disease: A Population-Based Prospective Cohort Study
Publication Year: 2025 Source: Aliment Pharmacol Ther PMID: 39957597 DOI: 10.1111/apt.70031
BACKGROUND: The combined effects of some modifiable lifestyle factors on incident inflammatory bowel disease (IBD) are uncertain. AIMS: To evaluate the combined association between healthy lifestyle behaviours and IBD incidence. METHODS: This population-based prospective cohort study used data from the UK Biobank. We included 105,715 participants aged 40-70 who had …
Evaluation of Anti-Inflammatory and Antioxidant Effects of Ferulic Acid and Quinic Acid on Acetic Acid-Induced Ulcerative Colitis in Rats
Publication Year: 2025 Source: J Biochem Mol Toxicol PMID: 39957712
Ulcerative colitis is a chronic inflammatory disease characterized by oxidative stress and the production of pro-inflammatory cytokines. Ferulic acid and quinic acid, two phenolic compounds, are thought to have potent antioxidant and anti-inflammatory properties. This study aimed to investigate the anti-inflammatory and antioxidant effects of ferulic acid and quinic acid …
Role of Mesenteric Defect Closure in Preventing Internal Hernias After Ileocecectomy With Kono-S Anastomosis
Publication Year: 2025 Source: Cureus PMID: 39958003
Crohn's disease is a chronic inflammatory bowel condition that frequently leads to complications such as strictures and bowel obstruction, often necessitating surgical intervention. Surgical approaches like ileocecectomy and right colectomy are commonly performed, with an ongoing debate about whether to close the mesenteric defect during these procedures to prevent internal …
The immunoregulatory effects of scoparone on immune-mediated inflammatory diseases
Publication Year: 2025 Source: Front Immunol PMID: 39958341
Scoparone (SCO), also known as 6,7-Dimethoxycoumarin, is a naturally occurring bioactive ingredient originally derived from Chinese herb Artemisiae Scopariae Herba (Yin-Chen-Hao). Previous studies have shown that it is effective in treating some of the liver diseases. Beyond its hepatoprotective effects, an expanding body of research has underscored the immunoregulatory properties …
Keratin 1 modulates intestinal barrier and immune response via kallikrein kinin system in ulcerative colitis
Publication Year: 2025 Source: World J Gastroenterol PMID: 39958441
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