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Therapeutic drug monitoring and immunogenetic factors associated with the use of adalimumab in Crohn's disease patients
Publication Year: 2025 Source: Int J Immunopathol Pharmacol PMID: 39959979
Crohn's disease (CD) involves immune system interactions with intestinal tissue, driven by pro-inflammatory cytokines like Tumor Necrosis Factor (TNF-alpha). Adalimumab, targeting TNF-alpha, regulates associated inflammatory responses. Despite being humanized, it may induce immunogenic processes, affecting treatment effectiveness. Thus, monitoring serum adalimumab and anti-drug antibody (ADA) levels can optimize therapy. Understanding …
Role of TAK-242-Induced Histone Lactylation in Modulating Repair Macrophage Transformation in Ulcerative Colitis
Publication Year: 2025 Source: Immunol Invest PMID: 39960076
BACKGROUND: Ulcerative Colitis (UC) is a condition that causes ulceration and inflammation of the intestinal epithelium. UC treatment depends on macrophages' phenotypic switch from pro-inflammatory (M1) to anti-inflammatory and tissue-repairing (M2). It has been reported that the epigenetic alteration of histone lactylation affects macrophage activity and phenotype. TAK-242, a TLR4 …
Liver transplantation for cholestatic liver diseases: Timing and disease recurrence
Publication Year: 2025 Source: Hepatology PMID: 39960305
Though rare, primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC) account for 8%-14% of liver transplants (LTs) in North America and Europe and the journey of these patients across the peri-transplant period is unique. Equitable access to LT is an important challenge, as the MELD score and its derivatives …
S1P Lyase Inhibition Increased Intestinal S1P, Disrupted the Intestinal Barrier and Aggravated DSS-Induced Colitis
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 39960746 DOI: 10.1093/ibd/izaf030
BACKGROUND: Sphingosine-1-phospate (S1P) receptor agonists (eg, ozanimod) desensitize migrating lymphocytes by irreversibly binding to S1P receptors (S1PR) and triggering their proteasomal degradation. Desensitized lymphocytes cannot sense S1P, therefore, halting lymphocyte recirculation. The S1P lyase (SPL) irreversibly degrades S1P and its inhibition disrupts the S1P gradient. We previously found that systemic …
NHE3 Controls Proliferation and Migration of Colonic Epithelial Cells
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 39960764 DOI: 10.1093/ibd/izaf024
BACKGROUND: In the gut, Na+/H+ exchanger 3 (NHE3; SLC9A3) plays important roles in pH regulation, absorption of Na+, and indirectly of other nutrients. NHE3-deficient mice develop inflammatory bowel disease (IBD)-like dysbiosis and spontaneous colitis, and rare mutations in the SLC9A3 gene may confer a risk factor for very early-onset IBD. …
Ankylosing spondylitis and the genetic correlation of extra-articular manifestations: Evidence from bidirectional Mendelian randomization and Bayesian colocalization
Publication Year: 2025 Source: Medicine (Baltimore) PMID: 39960913
Spondyloarthritis (SpA) encompasses a group of inflammatory joint disorders affecting the spine and joints, including ankylosing spondylitis and nonradiographic axial SpA, exhibiting diverse extra-articular manifestations. Genetic factors, beyond human leukocyte antigen B27, play a significant role in SpA development. Leveraging advanced statistical methods, this study explores bidirectional Mendelian randomization (MR) …
Diabetes mellitus, metformin's target gene AMPK, and inflammatory bowel disease: A Mendelian randomization study
Publication Year: 2025 Source: Medicine (Baltimore) PMID: 39960958 DOI: 10.1097/MD.0000000000041532
The causal relationship between inflammatory bowel disease (IBD) and diabetes mellitus remains unclear. The aim of this study was to delve into this association and investigate the correlation between AMP-activated protein kinase (AMPK), a target gene of metformin, and the risk of developing IBD. Researchers conducted a bidirectional two-sample Mendelian …
Cytomegalovirus Colitis in 2 Patients With Kindler Syndrome
Publication Year: 2025 Source: Pediatr Infect Dis J PMID: 39961129
No Abstract
Switching intravenous to subcutaneous infliximab was safe and successful during 1-year follow up in Ulcerative Colitis and Crohn patients - a Belgian single center experience
Publication Year: 2025 Source: Acta Gastroenterol Belg PMID: 39961295 DOI: 10.51821/88.1.13222
BACKGROUND: Subcutaneous (SC) infliximab CT-P13 (IFX) has recently been registered for the treatment of moderate-to-severe inflammatory bowel disease (IBD). The SC route is an attractive option for patients. However, many open questions remain on how to safely switch patients from maintenance IV to SC administration. OBJECTIVE: to assess switching from …
[Position paper of the Society for Paediatric Gastroenterology and Nutrition (GPGE) on the off-label use of biologics and signal inhibitors in children and adolescents with IBD that have already been approved for adults]
Publication Year: 2025 Source: Z Gastroenterol PMID: 39961333 DOI: 10.1055/a-2474-3104
Therapy for children and adolescents with chronic inflammatory bowel disease (IBD) is basically no different from that for adult patients. However, of the steadily increasing number of biologics and signalling inhibitors for adults, only two TNFalpha antibodies are currently approved in Germany for the treatment of IBD from the age …
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