Research Articles Library
Literature Analysis Tools
Advanced Search
Filter by PMID, year, source, DOI and other criteria
Literature Analysis
Analyze research trends and hotspots
Batch Export
Export search results to Excel/PDF
Risk of serious bacterial infections in inflammatory rheumatic or bowel disease patients during biological therapies: nationwide Danish cohort study
Publication Year: 2025 Source: Ann Med PMID: 40560844 DOI: 10.1080/07853890.2025.2522968
INTRODUCTION: To estimate the incidence rate ratio (IRR) of serious bacterial infections (SI) in patients with inflammatory bowel disease (IBD) or inflammatory rheumatic disease (IRD) before and after initiating biological therapy, and to assess comorbidities, infection sites, and the type of biological therapy. METHODS: This nationwide retrospective registry-based study used …
Phosphocreatine rescues intestinal epithelial metabolic dysfunction related to creatine kinase loss and is protective in murine colitis
Publication Year: 2025 Source: Cell Mol Gastroenterol Hepatol PMID: 40562094 DOI: 10.1016/j.jcmgh.2025.101557
BACKGROUND AND AIMS: Inflammatory bowel disease (IBD) is associated with intestinal energetic derangements, including reduced creatine kinase (CK) expression. CK is critical to cellular energetics, catalyzing bidirectional transfer of high-energy phosphate between creatine and ATP, and phosphocreatine (PCr) and ADP. However, the impact of CK loss on intestinal epithelial cells …
Exercise-induced metabolite Lac-Phe ameliorates colitis by inhibiting M1 macrophage polarization via the suppression of the NF-κB signaling pathway
Publication Year: 2025 Source: Cell Mol Gastroenterol Hepatol PMID: 40562095 DOI: 10.1016/j.jcmgh.2025.101558
BACKGROUND AND AIMS: Although the anti-inflammatory benefits of exercise are well-documented, the specific mechanisms responsible for these advantages remain uncertain. N-lactoyl-phenylalanine (Lac-Phe), a major metabolite produced during exercise, is synthesized through the condensation of lactic acid and phenylalanine, catalyzed by the CNDP2. However, the potential anti-inflammatory properties of Lac-Phe remain …
Reflections on the Use of Preclinical Protein Signatures for IBD Diagnosis
Publication Year: 2025 Source: Gastroenterology PMID: 40562241 DOI: 10.1053/j.gastro.2024.12.045
No Abstract
Adherence to RECORD reporting guidelines among observational studies using routinely collected health data published in general medical journals: a metaepidemiologic study
Publication Year: 2025 Source: J Clin Epidemiol PMID: 40562253
OBJECTIVES: The REporting of studies Conducted using Observational Routinely Collected Data (RECORD) tool was developed to address gaps around reporting routinely collected health data. The objective of this study was to assess adherence to RECORD in general medical journals and to evaluate its correlation with study quality. METHODS: We searched …
Mesenchymal stem cell in immunomodulation of dendritic cells: Implications for inflammatory bowel disease therapy
Publication Year: 2025 Source: Autoimmun Rev PMID: 40562293 DOI: 10.1016/j.autrev.2025.103861
Inflammatory bowel disease (IBD) is a highly prevalent and recurrent autoimmune disorder characterized by dysregulation of the immune system leading to intestinal inflammation. Currently, available clinical treatments, such as mesalazine, are mainly used to alleviate symptoms but do not cure the disease. Mesenchymal stem cells (MSCs), as an emerging therapeutic …
Presence of viable gram-positive bacteria in blood of patients with inflammatory bowel disease is not affected by treatment
Publication Year: 2025 Source: Sci Rep PMID: 40562776 DOI: 10.1038/s41598-025-07535-z
In inflammatory bowel disease (IBD) the pathogenetic process is characterized by dysbiosis, increased permeability, translocation, and immune activation. The aim of the present study was to assess the presence of viable bacteria in the blood of patients with IBD and to correlate the findings with clinical characteristics. The study included …
Elevated long-to-very-long-chain ceramide ratio correlates with disease severity in inflammatory bowel disease and primary sclerosing cholangitis
Publication Year: 2025 Source: Sci Rep PMID: 40562812 DOI: 10.1038/s41598-025-07308-8
There is strong evidence that ceramides play a significant role in the pathology of inflammatory bowel disease (IBD) and chronic liver injury. Long-chain (LC) and very long-chain (VLC) ceramides have opposing functions, yet the associations of circulating levels of ceramide species in patients with IBD and primary sclerosing cholangitis (PSC)-as …
Single-cell and spatial transcriptomics of stricturing Crohn's disease highlights a fibrosis-associated network
Publication Year: 2025 Source: Nat Genet PMID: 40562913 DOI: 10.1038/s41588-025-02225-y
Fibrosis is a major complication of Crohn's disease (CD) marked by excess deposition of extracellular matrix, leading to stricturing and functional impairment. As mechanistic characterization and therapeutic options are lacking, we paired single-cell and spatial transcriptomics in 61 samples from 21 patients with CD and 10 patients without inflammatory bowel …
Mechanistic insights into periodontal ligament stem cell-derived exosomes in tissue regeneration
Publication Year: 2025 Source: Clin Oral Investig PMID: 40562987 DOI: 10.1007/s00784-025-06422-1
OBJECTIVE: This review comprehensively examined the emerging role of exosomes derived from periodontal ligament stem cells (PDLSC-Exos) in regenerative medicine and dentistry, with a particular focus on their therapeutic potential in periodontitis-a prevalent inflammatory disease characterized by the progressive destruction of periodontal tissues. METHODS: An initial search on Scopus, Web …
Need more literature?
The current database contains 98453 research articles. If you need to search for more literature or perform AI analysis, please use our knowledge acquisition module or explore external literature resources.
External Resources: Access comprehensive literature databases worldwide