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Sound of Success: Intestinal Ultrasound in the Management of Refractory Stricturing Crohn's Disease
Publication Year: 2025 Source: Dig Dis Sci PMID: 40563066
We present a case of a female with complex pediatric-onset stricturing small bowel and colonic Crohn's disease. She was refractory to multiple advanced therapies, requiring dual therapy with risankizumab and upadacitinib to induce healing. Using intestinal ultrasound to monitor her response to therapy, we ultimately de-escalated to risankizumab monotherapy due …
γδT Cells in IBD: Beneficial or Detrimental?
Publication Year: 2025 Source: Immunology PMID: 40563249 DOI: 10.1111/imm.70012
gammadeltaT cells play a crucial role in inflammatory bowel disease (IBD). Studies have shown that the number, subsets and secreted cytokines of gammadeltaT cells undergo changes in IBD. However, whether gammadeltaT cells are beneficial or detrimental in IBD remains controversial. Some studies suggest that gammadeltaT cells have a protective role …
Oxidative Stress, Gut Bacteria, and Microalgae: A Holistic Approach to Manage Inflammatory Bowel Diseases
Publication Year: 2025 Source: Antioxidants (Basel) PMID: 40563329 DOI: 10.3390/antiox14060697
Oxidative stress is a recognized contributor to the pathophysiology of inflammatory bowel disease (IBD), exacerbating chronic inflammation and tissue damage. While traditional IBD therapies primarily focus on immune modulation, alternative approaches that address oxidative stress and promote gut microbial health present new opportunities for symptom relief and disease management. Microalgae, …
Puerarin as a Phytochemical Modulator of Gastrointestinal Homeostasis in Livestock: Molecular Mechanisms and Translational Applications
Publication Year: 2025 Source: Antioxidants (Basel) PMID: 40563388
The gut serves as the main site for nutrient digestion and absorption. Simultaneously, it functions as the body's largest immune organ, playing a dual role in sustaining physiological equilibrium and offering immunological defense against intestinal ailments. Maintaining the structural and functional integrity of the intestine is paramount for ensuring animal …
Dairy Propionibacteria: Probiotic Properties and Their Molecular Bases
Publication Year: 2025 Source: Biomolecules PMID: 40563526
This review summarizes the current knowledge on the probiotic characteristics of dairy propionibacteria, represented by Propionibacterium freudenreichii and some Acidipropionibacterium species commonly consumed through raw milk cheese. For example, in Swiss-type cheeses, P. freudenreichii is added as a starter culture. Some strains of P. freudenreichii have been included in mixed …
Vitamin D Modified DSS-Induced Colitis in Mice via STING Signaling Pathway
Publication Year: 2025 Source: Biology (Basel) PMID: 40563965
Although the underlying mechanisms are not yet fully understood, vitamin D has been proven to be associated with the pathogenesis of inflammatory bowel disease, participating in immune response and regulating gut microbiota composition. In this study, we established a dextran sodium sulfate-induced colitis model and intervened with vitamin D. Subsequently, …
Targeting Phosphodiesterase 4 in Gastrointestinal and Liver Diseases: From Isoform-Specific Mechanisms to Precision Therapeutics
Publication Year: 2025 Source: Biomedicines PMID: 40564004
Phosphodiesterase 4 (PDE4) serves as a crucial regulator of cyclic adenosine monophosphate (cAMP) signaling and has been identified as a significant therapeutic target for inflammatory and metabolic disorders impacting the gastrointestinal (GI) tract and liver. Although pan-PDE4 inhibitors hold therapeutic promise, their clinical use has been constrained by dose-dependent adverse …
Clinical Utility of Trabecular Bone Score in Gastroenterology: A Narrative Review
Publication Year: 2025 Source: Biomedicines PMID: 40564050 DOI: 10.3390/biomedicines13061331
No Abstract
Gut Feelings: How Microbes, Diet, and Host Immunity Shape Disease
Publication Year: 2025 Source: Biomedicines PMID: 40564077
The human gut microbiome is intricately linked to systemic and organ-specific immune responses and is highly responsive to dietary modulation. As metagenomic techniques enable in-depth study of an ever-growing number of gut microbial species, it has become increasingly feasible to decipher the specific functions of the gut microbiome and how …
Possible Applications of Fecal Microbiota Transplantation in the Pediatric Population: A Systematic Review
Publication Year: 2025 Source: Biomedicines PMID: 40564111
Background: The potential therapeutic role of fecal microbiota transplantation (FMT) in various diseases has been thoroughly studied over the last few decades. However, the majority of studies focus on the adult population, therefore, conclusions regarding the application of FMT in the pediatric population are much less clear. This systematic review …
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