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Long-acting injectable nanoparticle formulation for sustained release of anti-TNF-α antibody therapeutic in ulcerative colitis treatment
Publication Year: 2025 Source: J Control Release PMID: 39978474 DOI: 10.1016/j.jconrel.2025.02.043
Inflammatory bowel diseases (IBD) are chronic, remitting, and relapsing conditions of the gastrointestinal tract with incompletely elucidated etiology. The anti-TNF-alpha mAbs represent one of aflash nanocomplexation and flash nanoprecipitation process, resulting in particles with a narrow size distribution and tunable release profile, with the longest in vitro release lasting over …
Spinal astrocyte-derived M-CSF mediates microglial reaction and drives visceral hypersensitivity following DSS-induced colitis
Publication Year: 2025 Source: Neuropharmacology PMID: 39978590 DOI: 10.1016/j.neuropharm.2025.110373
Visceral hypersensitivity is one of the most prevalent symptoms of inflammatory bowel disease (IBD), and it can be difficult to cure despite achieving endoscopic remission. Accumulating studies have described that macrophage colony-stimulating factor (M-CSF) modulates neuroinflammation in the central nervous system (CNS) and the development of chronic pain, while the …
Systematic druggable genome-wide Mendelian randomization to identify therapeutic targets and dominant flora for ulcerative colitis
Publication Year: 2025 Source: Pharmacol Res PMID: 39978659
The relationship and mechanism among gut microbiota (GM), metabolites and active ulcerative colitis (UC) are unclear. This study aims to infer the causal relationship between druggable-genes and active UC using Mendelian randomization (MR) and bioinformatics methods. The "microbiota-target" and "microbiota- metabolite" network was constructed to screen the microorganisms and metabolites …
Dextran from human feces-derived Weissella cibaria facilitates intestinal mucosal barrier function by modulating gut bacteria and propionate levels
Publication Year: 2025 Source: Carbohydr Polym PMID: 39978893
The disruption of the intestinal mucosal barrier is strongly associated with the onset of various diseases, including inflammatory bowel disease. Exopolysaccharides (EPS) support the functionality of the intestinal barrier. Weissella Cibaria (W. cibaria), belonging to the lactic acid bacteria, exhibits a significant capacity for EPS production. However, the specific mechanisms …
The gut-organ axis: Clinical aspects and immune mechanisms
Publication Year: 2025 Source: Allergol Int PMID: 39979198 DOI: 10.1016/j.alit.2025.01.004
The gut-brain axis exemplifies the bidirectional connection between the intestines and the brain, as evidenced by the impact of severe stress on gastrointestinal symptoms including abdominal pain and diarrhea, and conversely, the influence of abdominal discomfort on mood. Clinical observations support the notion of the gut-brain connection, including an increased …
S1PR1-biased activation drives the resolution of endothelial dysfunction-associated inflammatory diseases by maintaining endothelial integrity
Publication Year: 2025 Source: Nat Commun PMID: 39979282 DOI: 10.1038/s41467-025-57124-x
G protein-coupled sphingosine-1-phosphate receptor 1 (S1PR1), a drug target for inflammatory bowel disease (IBD), enables immune cells to egress from lymph nodes, but the treatment increases the risk of immunosuppression. The functional signaling pathway triggered by S1PR1 activation in endothelial cells and its therapeutic application remains unclear. Here, we showed …
Pouch outcomes after minimally invasive vs. open proctectomy during IPAA reconstruction
Publication Year: 2025 Source: Surg Endosc PMID: 39979620
BACKGROUND: There is limited data on pouch outcomes after minimally invasive (MIS) proctectomy during ileal pouch-anal anastomosis (IPAA). This study aimed to determine if MIS proctectomy is associated with differences in pouch complications compared to open. METHODS: We performed a retrospective cohort study of patients from two academic institutions (2010-2022) …
Casual effect of ulcerative colitis on chronic heart failure: results from a bidirectional Mendelian randomization study
Publication Year: 2025 Source: BMC Gastroenterol PMID: 39979878
This study aimed to detect the causal effect of ulcerative colitis (UC) on heart failure. A bidirectional two-sample Mendelian randomization (MR) analysis was performed. The causal impact of UC on heart failure was determined via MR by performing a genome-wide association study in which 4 UCs descending from European ancestors …
Sexual satisfaction and associated factors among patients with inflammatory bowel disease in Japan
Publication Year: 2025 Source: Jpn J Nurs Sci PMID: 39980253
AIM: This study aimed to identify sexual satisfaction and related factors in Japanese patients with inflammatory bowel disease, as well as the characteristics of patients who refrained from responding to the sexual satisfaction question. METHODS: A questionnaire survey was administered to 499 patients, of whom 492 were available for the …
Characteristics of Adult Intussusception due to Malignancy in Japanese Patients
Publication Year: 2025 Source: JGH Open PMID: 39981119
AIMS: Adult intussusception (AI) is often associated with organic diseases. However, few studies have examined the causes of AI in Japanese patients. This study aimed to elucidate the clinical characteristics of AI due to malignancy in Japanese patients. METHODS AND RESULTS: From 2013 to 2021, 54 Japanese patients with AI …
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