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Association of over-the-counter mouthwash use with markers of nitric oxide metabolism, inflammation, and endothelial function-a cross-sectional study
Publication Year: 2025 Source: Front Oral Health PMID: 39981124
INTRODUCTION: Regular use of mouthwash can disrupt nitrate reduction by oral bacteria and may affect systemic nitric oxide (NO) levels, which are important for inflammation and endothelial function. We aim to assess the association between over-the-counter (OTC) mouthwash use and nitrate/nitrite, markers of inflammation (IL-6, TNF-alpha, CRP) and endothelial function …
Placebo-Controlled Trials in the Management of Crohn's Disease: An Umbrella Review of Meta-Analyses
Publication Year: 2025 Source: Med Sci (Basel) PMID: 39982236
INTRODUCTION: Crohn's disease is a chronic inflammatory bowel disease characterized by abdominal pain, diarrhea, and other symptoms. It can lead to significant complications and impact patients' quality of life. Therefore, effective management strategies are essential for improving outcomes. METHODS: To assess the efficacy of the treatments for Crohn's disease, this …
Single-Cell Transcriptomic Profile of Innate Cell Populations in Mesenteric Lymph Nodes of Inflammatory Bowel Disease Patients
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 39982469 DOI: 10.1093/ibd/izaf017
BACKGROUND AND AIMS: Innate immune cells, including dendritic cells (DCs), monocytes (Mono), macrophages (Mac), natural killer (NK), and innate lymphoid cells (ILC), contribute to chronic inflammation in lymphoid tissues. Here, we characterized the innate immune cell landscape in inflamed mesenteric lymph nodes (MLNs) of patients with inflammatory bowel diseases (IBD) …
Erythrocyte Methotrexate-Polyglutamate Concentrations in Pediatric Inflammatory Bowel Disease
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 39982703 DOI: 10.1093/ibd/izaf035
BACKGROUND AND AIMS: Therapeutic drug monitoring (TDM) of methotrexate (MTX) is challenging due to its pharmacokinetics and short plasma half-life. Intracellular MTX-polyglutamates (PG1-5), which accumulate over time, have not been assessed in pediatric inflammatory bowel disease (IBD). This study aimed to evaluate erythrocyte MTX-PG as a potential TDM tool in …
Restraint of inflammasome-driven cytokine responses through the mRNA stability protein TTP
Publication Year: 2025 Source: Cell Rep PMID: 39982821
Activation of the NLRP3 inflammasome causes extensive disturbance of cellular homeostasis, with Golgi disruption, mitochondrial dysfunction, and changes in intracellular ion concentration occurring rapidly upon stimulation. Given this, it would seem near certain that these changes might also globally affect cellular signaling pathways, yet few, if any, studies have explored …
Placental Transfer of Upadacitinib Among Pregnant Women with Inflammatory Bowel Disease
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 39982830
No Abstract
An electroadhesive hydrogel interface prolongs porcine gastrointestinal mucosal theranostics
Publication Year: 2025 Source: Sci Transl Med PMID: 40009695
Establishing a robust and intimate mucosal interface that allows medical devices to remain within lumen-confined organs for extended periods has valuable applications, particularly for gastrointestinal theranostics. Here, we report the development of an electroadhesive hydrogel interface for robust and prolonged mucosal retention after electrical activation (e-GLUE). The e-GLUE device is …
Sea buckthorn berries alleviate ulcerative colitis via regulating gut Faecalibaculum rodentium-mediated butyrate biosynthesis
Publication Year: 2025 Source: Phytomedicine PMID: 40010029
BACKGROUND: The gut microbiota is firmly associated with the progression of ulcerative colitis (UC). Beneficial microbial metabolites, such as butyrate, exert vital roles in maintaining intestinal homeostasis. The Sea buckthorn berry is a traditional Chinese medicine homologous to food and medicine which is widely applied in the prevention and treatment …
TL1A, a novel alarmin in airway, intestinal, and autoimmune disorders
Publication Year: 2025 Source: J Allergy Clin Immunol PMID: 40010414
The term alarmin denotes a broad class of molecules rapidly released to alert the immune system through the engagement of specific receptors on immune cells. Three alarmin cytokines-thymic stromal lymphopoietin, IL-33, and IL-25-are released from epithelial and certain stromal cells. TNF-like cytokine 1A (TL1A) is a member of the TNF …
Epstein-Barr Virus Exposure Precedes Crohn's Disease Development
Publication Year: 2025 Source: Gastroenterology PMID: 40010579 DOI: 10.1053/j.gastro.2025.01.247
No Abstract
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