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From microbiota to menu: predicting individual responses to dietary components
Publication Year: 2025 Source: Gut PMID: 40011032
No Abstract
Underwater endoscopic submucosal dissection for large non-pedunculated colorectal polyps
Publication Year: 2025 Source: Gut PMID: 40011034 DOI: 10.1136/gutjnl-2025-334995
No Abstract
Hawthorn Pectin Alleviates DSS-Induced Colitis in Mice by Ameliorating Intestinal Barrier Function and Modulating Gut Microbiota
Publication Year: 2025 Source: J Agric Food Chem PMID: 40011195
Pectin, as a kind of soluble dietary fiber in hawthorns, exhibits a wide range of biological activities. Nevertheless, its role and mechanism in ulcerative colitis (UC) remain unclear. In this study, the effect of hawthorn pectin (HP) against dextran sulfate sodium (DSS)-induced UC in mice and its underlying mechanism were …
IgA nephropathy and IgA vasculitis in a pediatric Crohn's disease patient with early IgA deposition in vascular walls of intestines
Publication Year: 2025 Source: CEN Case Rep PMID: 40011366
Patients with inflammatory bowel disease may present with extraintestinal manifestations. Crohn's disease complicated with IgA nephropathy or IgA vasculitis is relatively rare. In this case, an 11-year-old girl was diagnosed with Crohn's disease and infliximab was administered. 1 year after treatment, she presented with asymptomatic but persistent microscopic hematuria. The …
Hypothesizing mechanistic links between microbes and disease using knowledge graphs
Publication Year: 2025 Source: Sci Rep PMID: 40011529
Knowledge graphs have been a useful tool for many biomedical applications because of their effective representation of biological concepts. Plentiful evidence exists linking the gut microbiome to disease in a correlative context, but uncovering the mechanistic explanation for those associations remains a challenge. Here we demonstrate the potential of knowledge …
Intestinal fibrosis associated with inflammatory bowel disease: Known and unknown
Publication Year: 2025 Source: Chin Med J (Engl) PMID: 40012095 DOI: 10.1097/CM9.0000000000003545
Intestinal fibrosis is a major complication of inflammatory bowel disease (IBD), leading to a high incidence of surgical interventions and significant disability. Despite its clinical relevance, no targeted pharmacological therapies are currently available. This review aims to explore the underlying mechanisms driving intestinal fibrosis and address unresolved scientific questions, offering …
Observation of the efficacy of upadacitinib as salvage therapy for refractory pediatric inflammatory bowel disease
Publication Year: 2025 Source: J Pediatr Gastroenterol Nutr PMID: 40012236
No Abstract
Discovery of a Novel CRBN-Recruiting cGAS PROTAC Degrader for the Treatment of Ulcerative Colitis
Publication Year: 2025 Source: J Med Chem PMID: 40012371
Cyclic GMP-AMP synthase (cGAS), a critical cytosolic DNA sensor initiating innate immune responses in the presence of cytosolic DNA, is increasingly recognized as a promising therapeutic target for ulcerative colitis (UC). Here, we reported the design, synthesis, structure-activity relationship exploration and biological evaluation of a novel class of CRBN-recruiting cGAS-targeting …
Alleviation of DSS-induced colitis by Meconopsis polysaccharides correlated with reduced PI3K/AKT signaling and gut microbiome diversity
Publication Year: 2025 Source: Front Pharmacol PMID: 40012624 DOI: 10.3389/fphar.2025.1459668
INTRODUCTION: Inflammatory bowel disease (IBD) is a recurrent gastrointestinal disorder that significantly impacts patients' quality of life globally. This study focuses on the polysaccharides (MP) extracted from Meconopsis integrifolia, to investigate its role in alleviating DSS (dextran sulfate sodium)-induced colitis in mice. METHODS: The study commenced with a comprehensive chemical …
Spectrum of venous thromboembolism in adult patients with ulcerative colitis in Pakistan: A single center retrospective study
Publication Year: 2025 Source: World J Clin Cases PMID: 40012826
BACKGROUND: Patients with inflammatory bowel disease are at a 2-8-fold higher risk of developing venous thromboembolism (VTE) as compared to the general population. Although the exact pathogenesis is unclear, the literature suggests that increased risk of thromboembolic events in such patients occurs as a result of increased coagulation factors, inflammatory …
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