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Azathioprine and 6-mercaptopurine for maintenance of remission in ulcerative colitis
Publication Year: 2025 Source: Cochrane Database Syst Rev PMID: 40013523 DOI: 10.1002/14651858.CD000478.pub5
BACKGROUND: Maintenance of remission is essential in inflammatory bowel disease (IBD) in terms of disease course and long-term prognosis. The thiopurines azathioprine and 6-mercaptopurine have longstanding merit in ulcerative colitis, but more therapeutic options have been developed. This review is an update and extension of a review last published in …
Spine and Sacroiliac Joint Involvement in Newly Diagnosed Patients With Inflammatory Bowel Disease: Clinical and MRI Findings From a Population-Based Cohort
Publication Year: 2025 Source: Am J Gastroenterol PMID: 40013833
No Abstract
TA-V Nanozymes with Acid Resistance Capabilities Effectively Target and Alleviate Ulcerative Colitis Lesions via Oral Delivery
Publication Year: 2025 Source: ACS Appl Mater Interfaces PMID: 40013919
As one of the most common inflammatory bowel diseases (IBDs), ulcerative colitis (UC) has become a rising global health issue that affects people's quality of life. Conventional therapeutic drugs have low bioavailability and may cause serious side effects due to their lack of acidic resistance and lesion-targeting capabilities. The development …
Advances in Fecal Microbiota Transplantation for Gut Dysbiosis-Related Diseases
Publication Year: 2025 Source: Adv Sci (Weinh) PMID: 40013938 DOI: 10.1002/advs.202413197
This article provides an overview of the advancements in the application of fecal microbiota transplantation (FMT) in treating diseases related to intestinal dysbiosis. FMT involves the transfer of healthy donor fecal microbiota into the patient's body, aiming to restore the balance of intestinal microbiota and thereby treat a variety of …
Network pharmacology analysis and animal experiment validation of inflammation inhibition by Swertiamarin in treating Ulcerative colitis
Publication Year: 2025 Source: Naunyn Schmiedebergs Arch Pharmacol PMID: 40014128
Ulcerative colitis (UC), a chronic inflammatory bowel disease with increasing global incidence and limited therapeutic options, underscores the urgent need for novel multi-target agents. Swertiamarin (STM), a secoiridoid glycoside derived from traditional medicine, exhibits anti-inflammatory properties, but its pharmacological mechanisms in UC remain unclear. In this study, we integrated network …
Engineered bacteria and bacterial derivatives as advanced therapeutics for inflammatory bowel disease
Publication Year: 2025 Source: Essays Biochem PMID: 40014418 DOI: 10.1042/EBC20253003
Inflammatory bowel disease (IBD), a chronic and relapsing-remitting condition, is inadequately managed by conventional therapies that often lack targeting specificity and carry significant side effects, particularly failing to address intestinal barrier repair and microbial balance. Probiotics, with their strong colonization capabilities, present a novel approach to drug delivery. Various engineering …
Pregnancy-Induced Hypertension and Association With Future Autoimmune Diseases
Publication Year: 2025 Source: Obstet Gynecol PMID: 40014856
OBJECTIVE: To explore the associations between hypertensive disorders of pregnancy and the subsequent development of autoimmune diseases. METHODS: This retrospective cohort study used TriNetX, a federated network of real-world data. Using the Global Collaborative Network data, we collected electronic medical records from 102 health care organizations with 131 million patient …
Apigenin alleviates inflammation as a natural IRAK4 inhibitor
Publication Year: 2025 Source: Phytomedicine PMID: 40015172
BACKGROUND: Uncontrolled inflammation is a key factor in the development of many diseases, and targeting pivotal kinases involved in the inflammatory response, such as interleukin-1 receptor-associated kinase 4 (IRAK4), holds promise for the treatment of inflammatory conditions. Apigenin (Api) is a popular element in numerous plants, possessing anti-inflammatory properties. Many …
No Increased Risk of Venous Thromboembolism or Infectious Complications after Janus Kinase Inhibitor Exposure in Patients with Ulcerative Colitis Undergoing Surgery
Publication Year: 2025 Source: Dig Dis PMID: 40015256
INTRODUCTION: Total colectomy for ulcerative colitis (UC) is associated with postoperative morbidity, including venous thromboembolic events (VTE). In light of recent concerns about increased major adverse events associated with Janus kinase (JAK) inhibitor exposure, we aimed to evaluate the postoperative VTE risk as well as other complications in UC patients …
High Amphiregulin Expression in Intestinal Biopsies of Pediatric Patients with Severe Acute Graft-Versus-Host Disease
Publication Year: 2025 Source: Transplant Cell Ther PMID: 40015568 DOI: 10.1016/j.jtct.2025.02.020
Acute graft-versus-host disease (GvHD) is a major complication of hematopoietic cell transplantation (HCT). Despite of recent advances in prophylaxis, diagnosis and treatment it is still a serious cause of morbidity and mortality after HCT. Amphiregulin (AREG) is an epidermal growth factor receptor ligand known for restoring damaged intestinal tissue. AREG …
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