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Mesenchymal Stem Cells Armed with DNA Nanorobots as a Modality for Combination Therapy of Inflammatory Bowel Disease
Publication Year: 2025 Source: ACS Appl Mater Interfaces PMID: 40017400 DOI: 10.1021/acsami.4c08923
Therapeutic strategies that can target multilevel immunoregulatory pathways in inflammatory bowel disease (IBD) and efficiently target the site of inflammation are expected to greatly enhance the therapeutic efficacy. Here, we have developed a DNA nanorobot-armed bidirectional resistant mesenchymal stem cell (MSC) for IBD treatment, which blocks lymphocyte infiltration at the …
Ketamine cholangiopathy: clinical features and liver biopsy findings
Publication Year: 2025 Source: Histopathology PMID: 40017428
AIMS: To reveal clinical, imaging and pathological features of ketamine cholangiopathy. METHODS AND RESULTS: Eight cases, who had a history of long-term ketamine use, abnormal liver function tests and histological or radiological evidence of cholangiopathy, were retrospectively reviewed. Cases consisted of six men and two women with a median age …
Aseptic Abscess Syndrome: A Case Report of a Rare Extraintestinal Manifestation of Inflammatory Bowel Disease
Publication Year: 2025 Source: Case Rep Gastroenterol PMID: 40017495
INTRODUCTION: Aseptic hepatic abscesses are a highly uncommon phenomenon and even more rare in the spectrum of extraintestinal manifestations of inflammatory bowel disease. Part of the spectrum of "neutrophilic disease," both the pathogenesis and the optimal management of these aseptic abscesses remain unclear. In the context of inflammatory bowel disease, …
Multiple esophageal ulcers in a pediatric case of granulomatosis with polyangiitis: A case report
Publication Year: 2025 Source: DEN Open PMID: 40017513
A 14-year-old girl presented with diarrhea and bloody stools was initially diagnosed with infectious colitis and anal fissure. The patient was treated with antibiotics; however, the symptoms persisted and purpura appeared on the patient's lower abdomen. Abdominal computed tomography indicated diffuse wall thickening of the entire colon. A colonoscopy revealed …
Elevated levels of IRF1 and CASP1 as pyroptosis-related biomarkers for intestinal epithelial cells in Crohn's disease
Publication Year: 2025 Source: Front Immunol PMID: 40018047
INTRODUCTION: Crohn's disease (CD) is a complex inflammatory condition with the potential for severe complications. Pyroptosis is an inflammatory form of programmed cell death, and the role of pyroptosis in intestinal epithelial cells of CD remains unclear. METHODS: In this study, pyroptosis-related hub genes were identified using datasets from the …
A preliminary study of the association between Blastocystis and quantification of selected yeasts in IBD and IBS patients
Publication Year: 2025 Source: Front Med (Lausanne) PMID: 40018349 DOI: 10.3389/fmed.2025.1514587
OBJECTIVE: Irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD) are gastrointestinal disorders, which can be triggered by gut microbiota dysbiosis. The development of IBS-like symptoms has been linked to the overgrowth of Candida spp. In addition, the critical role of fungi has been highlighted in the pathogenesis of IBD. …
A Pelvic Mass in a Young Patient With Crohn's Disease
Publication Year: 2025 Source: ACG Case Rep J PMID: 40018696
Castleman disease (CD) is a rare group of lymphoproliferative disorders subdivided based on clinical features. Although not fully understood, the pathogenesis of both CD and Crohn's disease involves a combination of immune dysregulation and infectious and environmental factors. Interleukin-6, a proinflammatory cytokine, is associated with both diseases and can serve …
Diagnostic accuracy of convolutional neural network algorithms to distinguish gastrointestinal obstruction on conventional radiographs in a pediatric population
Publication Year: 2025 Source: Diagn Interv Radiol PMID: 40018794
PURPOSE: Gastrointestinal (GI) dilatations are frequently observed in radiographs of pediatric patients who visit emergency departments with acute symptoms such as vomiting, pain, constipation, or diarrhea. Timely and accurate differentiation of whether there is an obstruction requiring surgery in these patients is crucial to prevent complications such as necrosis and …
Distinct Profiles of Fecal Volatile Organic Compounds Discriminate Ulcerative Colitis Patients With an Ileoanal Pouch From Those With an Intact Colon
Publication Year: 2025 Source: Mol Nutr Food Res PMID: 40018833
Fecal volatile organic compounds (VOCs) offer insights into gut microbiota function that may drive the pathogenesis of ulcerative colitis (UC). This cross-sectional study aimed to compare dietary intake and VOC patterns in UC patients with an ileoanal pouch compared to those with an intact colon. Seven-day food records and fecal …
Innovative Gastrointestinal Drug Delivery Systems: Nanoparticles, Hydrogels, and Microgrippers
Publication Year: 2025 Source: Front Biosci (Landmark Ed) PMID: 40018918 DOI: 10.31083/FBL25281
Over the past decade, new technologies have emerged to increase intrinsic potency, enhance bioavailability, and improve targeted delivery of drugs. Most pharmaceutical formulations require multiple dosing due to their fast release and short elimination kinetics, increasing the risk of adverse events and patient non-compliance. Due to these limitations, enormous efforts …
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