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Improving the Real-Time Classification of Disease Severity in Ulcerative Colitis: Artificial Intelligence as the Trigger for a Second Opinion
Publication Year: 2025 Source: Am J Gastroenterol PMID: 40019166 DOI: 10.14309/ajg.0000000000003382
INTRODUCTION: Endoscopic classification of ulcerative colitis (UC) shows high interobserver variation. Previous research demonstrated that artificial intelligence (AI) can match the accuracy of central reading in scoring still images. We now extend this assessment to longer colon segments and integrate AI into clinical workflows, evaluating its use for real-time, video-based …
Delays in Utilizing Biological Therapy Is a Global Reality and May Lead to Negative Outcomes in Patients with Inflammatory Bowel Disease
Publication Year: 2025 Source: Dig Dis Sci PMID: 40019583
No Abstract
The role of gut microbiota and plasma metabolites in ulcerative colitis: Insights from Mendelian randomization analysis
Publication Year: 2025 Source: Medicine (Baltimore) PMID: 40020117
Emerging research suggests that alterations in gut microbiota composition may play a significant role in the pathogenesis of ulcerative colitis (UC). Plasma metabolites, which are influenced by gut microbiota, have also been implicated, but their role in UC remains unclear. This study aims to determine whether specific plasma metabolites mediate …
Risks of 75 major congenital malformations after in utero exposure to thiopurines and anti-TNF for maternal inflammatory bowel disease
Publication Year: 2025 Source: Clin Gastroenterol Hepatol PMID: 40020958 DOI: 10.1016/j.cgh.2025.01.008
BACKGROUND & AIMS: Limited data are available on the risk of major congenital malformations (MCMs) of thiopurines and anti-tumor necrosis factor (TNF) during pregnancy. In this study, we assess the risk of MCMs associated with maternal exposure to thiopurines and anti-TNF for the treatment of inflammatory bowel disease (IBD) during …
Ginsenoside Rg1 alleviated experimental colitis in obesity mice by regulating memory follicular T cells via Bcl-6/Blimp-1 pathway
Publication Year: 2025 Source: J Nutr Biochem PMID: 40021065
The pathological mechanisms of ulcerative colitis (UC) are closely related with abnormal memory follicular helper T (mTfh) cell subsets and the Bcl-6/Blimp-1 signaling pathway. Ginsenoside Rg1 (G-Rg1) has been confirmed to exhibit therapeutic effects in obese mice with dextran sulfate sodium (DSS)-induced ulcerative colitis. The aim of this study was …
Prevalence and impact of sarcopenia in patients with inflammatory bowel diseases: A prospective cohort study
Publication Year: 2025 Source: Clin Res Hepatol Gastroenterol PMID: 40021084 DOI: 10.1016/j.clinre.2025.102555
BACKGROUND: Inflammatory bowel disease (IBD) patients with sarcopenia are at increased morbidity risk. The aim of this study was to assess the prevalence of sarcopenia in IBD outpatients using both morphological and functional criteria. METHODS: In this prospective cohort study, all IBD patients admitted to the day hospital unit between …
Efficacy and safety of two-step acupuncture therapy for symptom relief in adults with mild to moderate ulcerative colitis: rationale and design of the TSA-UC randomised controlled trial
Publication Year: 2025 Source: BMJ Open PMID: 40021194 DOI: 10.1136/bmjopen-2024-094301
INTRODUCTION: Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) characterised by episodes of symptoms including rectal bleeding, increased stool frequency and abdominal pain, impacting quality of life significantly. Conventional treatments often come with potential side effects and may not be sufficient. Acupuncture is increasingly recognised for its potential …
The Use of Artificial Intelligence for Endoscopic Evaluation of the Small Bowel
Publication Year: 2025 Source: Gastrointest Endosc Clin N Am PMID: 40021233
There remains great potential for widespread implementation of artificial intelligence (AI) in managing small bowel disorders. Studies have shown excellent accuracy in diagnosing various diseases and lesions throughout the small bowel, with most showing equivalency or superiority to expert endoscopists or capsule readers. AI has significant potential to improve efficiency …
Artificial Intelligence in Inflammatory Bowel Disease
Publication Year: 2025 Source: Gastrointest Endosc Clin N Am PMID: 40021234 DOI: 10.1016/j.giec.2024.10.004
Artificial intelligence (AI) is being increasingly studied and implemented in gastroenterology. In inflammatory bowel disease (IBD), numerous AI models are being developed to assist with IBD diagnosis, standardization of endoscopic and radiologic disease activity, and predicting outcomes. Further prospective, multicenter studies representing diverse populations and novel applications are needed prior …
Metabolic activation and cytotoxicity of ibudilast mediated by CYP3A4
Publication Year: 2025 Source: Arch Toxicol PMID: 40021515 DOI: 10.1007/s00204-025-03995-4
Ibudilast (IBD) is a relatively nonselective inhibitor of phosphodiesterase, commonly used for treating asthma, progressive multiple sclerosis and other neuropathological pain conditions. Although IBD was considered safe and harmless to human health, its clinical use might be associated with reported increases of serum AST and ALT as well as liver …
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