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Daily Vitamin D3 Versus Stoss Vitamin D3 for Correction of 25OHD Deficiency in Children with Inflammatory Bowel Disease, a Randomised Controlled Trial
Publication Year: 2025 Source: Dig Dis Sci PMID: 40021606
INTRODUCTION: Vitamin D deficiency is common in Paediatric Inflammatory Bowel Disease (PIBD) and has been implicated in disease pathogenesis and disease exacerbation. Current guidelines recommend oral vitamin D supplementation when 25OHD levels are below 50 nmol/L. Supplementation comes in two forms: either a daily supplement of a low dose of …
Discordance between a deep learning model and clinical-grade variant pathogenicity classification in a rare disease cohort
Publication Year: 2025 Source: NPJ Genom Med PMID: 40021654
Genetic testing is essential for diagnosing and managing clinical conditions, particularly rare Mendelian diseases. Although efforts to identify rare phenotype-associated variants have focused on protein-truncating variants, interpreting missense variants remains challenging. Deep learning algorithms excel in various biomedical tasks(1,2), yet distinguishing pathogenic from benign missense variants remains elusive(3-5). Our investigation …
Molecular insights into ulcerative colitis and orbital inflammation
Publication Year: 2025 Source: Sci Rep PMID: 40021664
Ulcerative colitis (UC) is an increasingly prevalent inflammatory condition affecting the intestinal mucosa, while nonspecific orbital inflammation (NSOI) is a common non-neoplastic orbital disorder. Exploring the molecular interplay between UC and NSOI may help physicians make earlier diagnoses and enhance treatment approaches. We analyzed gene expression datasets (GSE58331, GSE105149, GSE206285, …
CGRPβ suppresses the pathogenesis of ulcerative colitis via the immunoproteasome
Publication Year: 2025 Source: Sci Rep PMID: 40021701
Various factors have been implicated in the pathogenesis of ulcerative colitis (UC), with immune system failure being the most important one. Calcitonin gene-related peptide (CGRP), a neuropeptide with two isoforms, CGRPalpha and CGRPbeta, has been reported to regulate the immune system. In this study, we investigated the role of CGRP …
Roux-en-Y gastric bypass-associated fecal tyramine promotes colon cancer risk via increased DNA damage, cell proliferation, and inflammation
Publication Year: 2025 Source: Microbiome PMID: 40022152 DOI: 10.1186/s40168-025-02049-2
BACKGROUND: Fecal abundances of Enterobacteriaceae and Enterococcaceae are elevated in patients following Roux-en-Y gastric bypass (RYGB) surgery. Concurrently, fecal concentrations of tyramine, derived from gut bacterial metabolism of tyrosine and/or food, increased post-RYGB. Furthermore, emerging evidence suggests that RYGB is associated with increased colorectal cancer (CRC) risk. However, the causal …
Identification of the key tryptophan metabolic characteristics of Lactiplantibacillus plantarum for aryl hydrocarbon receptor activation and ulcerative colitis alleviation
Publication Year: 2025 Source: Food Res Int PMID: 40022314
Lactiplantibacillus plantarum can activate aryl hydrocarbon receptor (AHR) signaling in the gut by metabolizing tryptophan, thereby counteracting inflammation. However, the tryptophan metabolic characteristics of microorganisms are strain-specific and significantly influence their AHR-activating effects. In this study, four strains with different tryptophan metabolic profiles were screened, and a dextran sulfate sodium-induced …
TCP80-1, a new levan-neoseries fructan from Tupistra chinensis Baker rhizomes alleviates ulcerative colitis induced by dextran sulfate sodium in Drosophila melanogaster model
Publication Year: 2025 Source: Food Res Int PMID: 40022382
Ulcerative colitis (UC) is a recurrent inflammation of the gastrointestinal tract, for which available treatment drugs are severely limited. Natural polysaccharides show potential for UC prevention. Herein, we extracted TCP80-1, a polysaccharide with significant anti-ulcerative colitis (UC) activity, from Tupistra chinensis Baker for the first time. Structure analysis revealed that …
Discovery of anti-inflammatory molecules from Dendrobium officinale based on activity labelled molecular networking and its alleviation effect on ulcerative colitis
Publication Year: 2025 Source: Food Res Int PMID: 40022397
The present study aimed to discover anti-inflammatory molecules from Dendrobium officinale using mass spectrometry-based molecular networking technology and evaluate its therapeutic potential against ulcerative colitis (UC). We employed activity-labeled molecular networking (ALMN) to identify anti-inflammatory molecules from D. officinale extracts. From 3700 metabolite molecules, five top anti-inflammatory molecules were prioritized …
Development of a bio-inspired phagocytic stable nanoghost with anti-inflammatory properties for management of inflammation in ulcerative colitis
Publication Year: 2025 Source: J Drug Target PMID: 40022643
BACKGROUND: New bio-mimetic approaches are needed to develop effective delivery systems for inflammation regulation in chronic diseases like ulcerative colitis, avoiding fast clearance by immune system. The cell membrane-coated nanoparticle with a therapeutic payload has been considered as a promising delivery system to address the requirement. METHODS: Here, Glibenclamide (GLY)-loaded …
Clinical Analysis of Pyroptosis-Related Long Non-Coding RNAs MIAT and Gm15441 in Colorectal Cancer Patients with a History of Ulcerative Colitis
Publication Year: 2025 Source: Asian Pac J Cancer Prev PMID: 40022694
BACKGROUND: Pyroptosis can play a significant role in the development of inflammatory bowel diseases such as ulcerative colitis (UC) and colorectal cancer (CRC). The expression pattern of two pyroptosis related-lncRNAs MIAT and Gm15441 was investigated in clinical samples of CRC with and without a history of UC. METHODS: In this …
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