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Design, synthesis and biological evaluation of diarylmethyl amine derivatives with anti-ulcerative colitis activity via inhibiting inflammation and oxidative stress
Publication Year: 2025 Source: Eur J Med Chem PMID: 40022876
Two series of diarylmethylamine derivatives were synthesized by 1,6-addition reaction between para-quinone methides and 1-methylpiperazine or 2-oxazolidinone, and their structures were identified by (1)H NMR,(13)C NMR and HRMS. In the lipopolysaccharide-induced inflammatory Raw264.7 cells model, 3-CF(3) modified active derivative 1l was screened out by inhibiting the excessive production of NO …
Toxicity and absorption of polystyrene micro-nanoplastics in healthy and Crohn's disease human duodenum-chip models
Publication Year: 2025 Source: J Hazard Mater PMID: 40022921
Micro and nanoplastics (MNPs) are widespread environmental and food web contaminants that are absorbed by the intestine and distributed systemically, but the mechanisms of uptake are not well understood. In a triculture small intestinal epithelial model, we previously found that uptake of 26 nm polystyrene MNPs (PS26) occurred by both …
Short-Term Exposure to Ambient Particulate Matter Pollution and Surgical Outcomes
Publication Year: 2025 Source: J Surg Res PMID: 40022947
INTRODUCTION: Particulate matter less than 2.5 mum in diameter (PM(2)(.5)) can activate inflammatory cascades, cause oxidative damage, and induce cell death. Short-term exposures to PM(2.5) have been associated with appendicitis and inflammatory bowel disease presentations, yet it is unclear if exposures may impact surgical recovery. METHODS: We conducted a retrospective …
The dietary inflammatory potential and its role in the risk and progression of inflammatory bowel disease: A systematic review
Publication Year: 2025 Source: Clin Nutr PMID: 40022954 DOI: 10.1016/j.clnu.2025.02.019
BACKGROUND & AIMS: Inflammation is central in inflammatory bowel disease (IBD) pathogenesis. Because of diet's pro- and anti-inflammatory properties, multiple observational studies have explored the link between the dietary inflammatory potential and IBD-related outcomes. We aimed to systematically review the literature and provide a comprehensive overview of the dietary inflammatory …
NAD(+) modulation of intestinal macrophages renders anti-inflammatory functionality and ameliorates gut inflammation
Publication Year: 2025 Source: Biomed Pharmacother PMID: 40022994 DOI: 10.1016/j.biopha.2025.117938
Macrophages can maintain gut immune homeostasis by driving clearance of infection, but also can prevent chronic inflammation and induce tissue repair. Reduced nicotinamide adenine dinucleotide (NAD(+)) levels in macrophages have been reported to be associated with the onset of severe colitis. Given that dysregulation of gut macrophages plays a significant …
Inflammatory bowel disease and neuropsychiatric disorders: Mechanisms and emerging therapeutics targeting the microbiota-gut-brain axis
Publication Year: 2025 Source: Pharmacol Ther PMID: 40023320 DOI: 10.1016/j.pharmthera.2025.108831
Crohn's disease (CD) and ulcerative colitis (UC) are the two major entities of inflammatory bowel disease (IBD). These disorders are known for their relapsing disease course and severe gastrointestinal symptoms including pain, diarrhoea and bloody stool. Accumulating evidence suggests that IBD is not only restricted to the gastrointestinal tract and …
Preparation of pH-enzyme dual-responsive gel microspheres and their treatment of ulcerative colitis
Publication Year: 2025 Source: Int J Biol Macromol PMID: 40023431
Mesalazine (MSZ), a first-line treatment for ulcerative colitis (UC), was formulated into acid-resistant, colon-targeted gel microspheres to reduce upper gastrointestinal tract (GIT) exposure and extend drug retention in the colon. In this study, we used MSZ/hydroxypropyl-beta-cyclodextrin (MSZ/HP-beta-CD) as the model drug, dopamine-modified sodium alginate (DA-SA) and konjac glucomannan (KGM) as …
Diagnostic evaluation and management of abdominal tuberculosis
Publication Year: 2025 Source: Indian J Tuberc PMID: 40023548
Abdominal Tuberculosis represents 11-16% of extrapulmonary tuberculosis and usually presents with vague abdominal symptoms that can mimic other diseases such as inflammatory bowel disorders, malignancy and sarcoidosis. Often the diagnosis is delayed and complications such as adhesions, obstruction, fistula or bleeding can occur. The common types are peritoneal and intestinal …
Unlocking the potential: FKK6 as a microbial mimicry-based therapy for chronic inflammation-associated colorectal cancer in a murine model
Publication Year: 2025 Source: J Pharmacol Exp Ther PMID: 40023602
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Comorbidities and Quality of Life in Hidradenitis Suppurativa
Publication Year: 2025 Source: Dermatol Clin PMID: 40023619
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