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Nonmedical switch of anti-TNF-α biosimilars has no major clinical, pharmacokinetic and psychological impact on patients with IBD - the SAFER Study
Publication Year: 2025 Source: Dig Liver Dis PMID: 40023750 DOI: 10.1016/j.dld.2025.01.206
BACKGROUND: Data on nonmedical switching from one anti-Tumor Necrosis Factor (TNF)-alpha biosimilar to another in inflammatory bowel disease (IBD) are relatively sparse. We aimed to study the effects of nonmedical switch from infliximab biosimilar CT-P13 to SB2 and from adalimumab biosimilar ABP 501 to SB5. METHODS: In this observational study, …
Genetic variation in targets of antihyperglycemic drugs and inflammatory bowel disease' risk: A mendelian randomization study
Publication Year: 2025 Source: Diabetes Metab Syndr PMID: 40023995 DOI: 10.1016/j.dsx.2025.103204
AIM: Antihyperglycemic drugs have potential therapeutic benefits for inflammatory bowel disease (IBD). We aimed to investigate the association between genetic variations in gene-targeted antihyperglycemic drugs and the risk of IBD. METHODS: Summary statistics for HbA1c data were from the UK Biobank including 344,182 participants. Statistics of IBD were obtained from …
Fibroblast Growth Factor 20 Attenuates Colitis by Restoring Impaired Intestinal Epithelial Barrier Integrity and Modulating Macrophage Polarization via S100A9 in an NF-κB-Dependent Manner
Publication Year: 2025 Source: Cell Mol Gastroenterol Hepatol PMID: 40024533
BACKGROUND & AIMS: Exogenous recombinant fibroblast growth factor 20 (FGF20) protein has been proved to treat ulcerative colitis; however, its mechanism of action remains unclear. This study aimed to explore the role and mechanism of action of FGF20 in ulcerative colitis. METHODS: Data from patients with ulcerative colitis were analyzed …
An Esophageal Luminal Diameter of 16 mm Predicts Dysphagia Resolution in Eosinophilic Esophagitis
Publication Year: 2025 Source: Dig Dis Sci PMID: 40024960
GOALS AND BACKGROUND: Eosinophilic Esophagitis (EoE) is a chronic inflammatory esophageal disorder, often complicated by strictures requiring dilation. There is limited information on the target esophageal luminal diameter (ELD) post-treatment to relieve symptoms. The aim of this study was to determine the ELD threshold associated with dysphagia resolution in EoE …
A case of relapsed pan-colonic ulcerative colitis accompanied with gastroduodenal lesions immediately after COVID-19
Publication Year: 2025 Source: Clin J Gastroenterol PMID: 40024991
Some patients with ulcerative colitis (UC) suffer from complicated UC-associated upper gastrointestinal lesions. However, the trigger of these lesions has not been clarified. Herein, we present a 28-year-old man with relapsed pan-colonic UC accompanied by gastroduodenal lesions immediately after contracting coronavirus disease 2019 (COVID-19). In this patient, UC relapsed approximately …
Genetic determinants of inflammatory cytokines and their causal relationship with inflammatory disorders of breast: a two-sample Mendelian randomization study
Publication Year: 2025 Source: Sci Rep PMID: 40025158 DOI: 10.1038/s41598-025-91723-4
This study utilized two-sample MR to investigate causality between genetically predicted inflammatory markers and the risk of IDB. This research leveraged publicly available GWAS summary statistics to collect data on inflammatory cytokines and IDB. The IVW method was primarily employed for causal inference, supplemented by weighted median, mode-based estimation, and …
Prediction of vedolizumab efficacy in ulcerative colitis: a nomogram incorporating pathological feature and serological marker
Publication Year: 2025 Source: Clin Exp Med PMID: 40025282
Vedolizumab (VDZ) is a humanized, gut-selective biologic used in the treatment of ulcerative colitis (UC). However, data on predictive factors for treatment response are limited. This study aims to develop a nomogram to predict VDZ treatment responsiveness in UC. We retrospectively collected clinical data from patients with moderate-to-severe active UC …
The Impact of Concomitant Hypothyroid Disease on the Course of Inflammatory Bowel Disease
Publication Year: 2025 Source: Dig Dis Sci PMID: 40025310 DOI: 10.1007/s10620-025-08956-6
BACKGROUND: Inflammatory bowel disease (IBD) is a chronic, immune-mediated inflammatory disorder of the gastrointestinal tract. In IBD, systemic inflammation and immune dysregulation may also impact extraintestinal organs, such as the thyroid gland. Despite this, little is known about the influence of concomitant hypothyroidism on the clinical course of IBD. METHODS: …
Pathological characteristics of inflammatory bowel diseases
Publication Year: 2025 Source: J Med Ultrason (2001) PMID: 40025407 DOI: 10.1007/s10396-025-01520-9
Inflammatory bowel disease (IBD) is an inflammatory disorder in which intestinal homeostasis is disrupted for some reason. Among them, ulcerative colitis (UC) and Crohn's disease (CD) are frequently referred to as IBD in the narrow sense, characterized by relapse episodes and remission periods. The differential diagnosis of IBD involves a …
Biological functions and therapeutic applications of human mucosal-associated invariant T cells
Publication Year: 2025 Source: J Biomed Sci PMID: 40025566 DOI: 10.1186/s12929-025-01125-x
Mucosal-associated invariant T (MAIT) cells are a unique subset of innate-like T lymphocytes that bridge innate and adaptive immunity. Characterized by their semi-invariant T cell receptor (TCR) and abundant localization in mucosal tissues, MAIT cells recognize microbial metabolites, primarily derived from the riboflavin biosynthesis pathway, presented by the major histocompatibility …
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